Montgomery E, Devaney KO, Giordano TJ, et al: Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg–like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin’s disease, and various sarcomas. .Mod Pathol 11::384. ,1998. .
Meis-Kindblom JM, Kindblom LG: Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet. .Am J Surg Pathol 22::911. ,1998. .
Michal M: Inflammatory myxoid tumor of the soft parts with bizarre giant cells. .Pathol Res Pract 194::529. ,1998. .
Jurcic V, Zidar A, Montiel MD, et al: Myxoinflammatory fibroblastic sarcoma: a tumor not restricted to acral sites. .Ann Diagn Pathol 6::272. ,2002. .
Meis-Kindblom JM, Kindblom LG: “Myxoinflammatory Fibroblastic Sarcoma,” in Tumors of the Soft Tissue and Bone: WHO Classification of Tumors, Pathology and Genetics Classification of Tumors, Pathology and Genetics, 1st Ed, ed by CMD Fletcher, KK Unni, F Mertens, p 96, IARC Press, Lyon, France. ,2002. .
Kovarik CL, Barrett T, Auerbach A, et al: Acral myxoinflammatory fibroblastic sarcoma: case series and immunohistochemical analysis. .J Cutan Pathol 35::192. ,2008. .
Narvaez JA, Martinez S, Dodd LG, et al: Acral myxoinflammatory fibroblastic sarcomas: MRI findings in four cases. .Am J Roentgenol 188::1302. ,2007. .
McFarlane R, Meyers AD, Golitz L: Myxoinflammatory fibroblastic sarcoma of the neck. .J Cutan Pathol 32::375. ,2005. .
Premalata CS, Rao CR, Padma M, et al: Myxoinflammatory fibroblastic sarcoma: report of a rare case at an unusual site with review of the literature. .Int J Dermatol 47::68. ,2008. .
Hassanein AM, Atkinson SP, Al-Quran SZ, et al: Acral myxoinflammatory fibroblastic sarcomas: are they all low-grade neoplasms?. J Cutan Pathol 35::186. ,2008. .
Sakaki M, Hirokawa M, Wakatsuki S, et al: Acral myxoinflammatory fibroblastic sarcoma: a report of five cases and review of the literature. .Virchows Arch 442::25. ,2003. .
Pohar-Marinsek Z, Flezar M, Lamovec J: Acral myxoinflammatory fibroblastic sarcoma in FNAB samples: can we distinguish it from other myxoid lesions?. Cytopathology 14::73. ,2003. .
Tateishi U, Hasegawa T, Onaya H, et al: MR appearance and pathologic correlation. .AJR Am J Roentgenol 184::1749. ,2005. .
Gonzalez-Campora R, Rios-Martin JJ, Solorzano-Amoretti A, et al: Fine needle aspiration cytology of an acral myxoinflammatory fibroblastic sarcoma: case report with cytological and cytogenetic findings. .Cytopathology 19::118. ,2008. .
Ida CM, Rolig KA, Hulshizer RL, et al: Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality. .Cancer Genet Cytogenet 177::139. ,2007. .
Lambert I, Debiec-Rychter M, Guelinckx P, et al: Acral myxoinflammatory fibroblastic sarcoma with unique clonal chromosomal changes. .Virchows Arch 438::509. ,2001. .
Mansoor A, Fidda N, Himoe E, et al: Myxoinflammatory fibroblastic sarcoma with complex supernumerary ring chromosomes composed of chromosome 3 segments. .Cancer Genet Cytogenet 152::161. ,2004. .
Lang JE, Dodd L, Martinez S, et al: Acral myxoinflammatory fibroblastic sarcoma. .Clin Orthop Relat Res 445::254. ,2006. .
Baumhoer D, Glatz K, Schulten HJ, et al: Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature. .Virchows Arch 451::923. ,2007. .
Alkuwari E, Gravel DH: A 30-year-old man with a soft tissue mass on the right elbow: inflammatory myxohyaline tumor of the distal extremities with prominent eosinophilic infiltrate. .Arch Pathol Lab Med 130::35. ,2006. .
Ebhardt H, Kosmehl H, Katenkamp D: Acral myxoinflammatory fibroblastic sarcoma: six cases of a tumor entity [in German]. .Pathologe 22::157. ,2001. .
Myxoinflammatory fibroblastic sarcoma of the soft tissues is a rare low-grade tumor of uncertain origin that most often occurs on the extremities of adults. The tumor predominantly involves the subcutaneous tissues of the hands and feet. Despite being a rare neoplasm, owing to its varied histologic appearance, myxoinflammatory fibroblastic sarcoma should be differentiated from various benign and malignant soft-tissue lesions. Myxoinflammatory fibroblastic sarcoma has been well described in pathology journals but not in the surgical literature. We report a case of myxoinflammatory fibroblastic sarcoma in a 19-year-old man with a plantar ulcer lesion in his left foot. To our knowledge, this is the first reported case in the literature involving the epidermis. (J Am Podiatr Med Assoc 100(6): 497–501, 2010)