• 1

    Montgomery E, Devaney KO, Giordano TJ, et al: Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg–like cells: a distinctive lesion with features simulating inflammatory conditions, Hodgkin’s disease, and various sarcomas. .Mod Pathol 11::384. ,1998. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Meis-Kindblom JM, Kindblom LG: Acral myxoinflammatory fibroblastic sarcoma: a low-grade tumor of the hands and feet. .Am J Surg Pathol 22::911. ,1998. .

  • 3

    Michal M: Inflammatory myxoid tumor of the soft parts with bizarre giant cells. .Pathol Res Pract 194::529. ,1998. .

  • 4

    Jurcic V, Zidar A, Montiel MD, et al: Myxoinflammatory fibroblastic sarcoma: a tumor not restricted to acral sites. .Ann Diagn Pathol 6::272. ,2002. .

  • 5

    Meis-Kindblom JM, Kindblom LG: “Myxoinflammatory Fibroblastic Sarcoma,” in Tumors of the Soft Tissue and Bone: WHO Classification of Tumors, Pathology and Genetics Classification of Tumors, Pathology and Genetics, 1st Ed, ed by CMD Fletcher, KK Unni, F Mertens, p 96, IARC Press, Lyon, France. ,2002. .

  • 6

    Kovarik CL, Barrett T, Auerbach A, et al: Acral myxoinflammatory fibroblastic sarcoma: case series and immunohistochemical analysis. .J Cutan Pathol 35::192. ,2008. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Narvaez JA, Martinez S, Dodd LG, et al: Acral myxoinflammatory fibroblastic sarcomas: MRI findings in four cases. .Am J Roentgenol 188::1302. ,2007. .

    • Search Google Scholar
    • Export Citation
  • 8

    McFarlane R, Meyers AD, Golitz L: Myxoinflammatory fibroblastic sarcoma of the neck. .J Cutan Pathol 32::375. ,2005. .

  • 9

    Premalata CS, Rao CR, Padma M, et al: Myxoinflammatory fibroblastic sarcoma: report of a rare case at an unusual site with review of the literature. .Int J Dermatol 47::68. ,2008. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10

    Hassanein AM, Atkinson SP, Al-Quran SZ, et al: Acral myxoinflammatory fibroblastic sarcomas: are they all low-grade neoplasms?. J Cutan Pathol 35::186. ,2008. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11

    Sakaki M, Hirokawa M, Wakatsuki S, et al: Acral myxoinflammatory fibroblastic sarcoma: a report of five cases and review of the literature. .Virchows Arch 442::25. ,2003. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Pohar-Marinsek Z, Flezar M, Lamovec J: Acral myxoinflammatory fibroblastic sarcoma in FNAB samples: can we distinguish it from other myxoid lesions?. Cytopathology 14::73. ,2003. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Tateishi U, Hasegawa T, Onaya H, et al: MR appearance and pathologic correlation. .AJR Am J Roentgenol 184::1749. ,2005. .

  • 14

    Gonzalez-Campora R, Rios-Martin JJ, Solorzano-Amoretti A, et al: Fine needle aspiration cytology of an acral myxoinflammatory fibroblastic sarcoma: case report with cytological and cytogenetic findings. .Cytopathology 19::118. ,2008. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15

    Ida CM, Rolig KA, Hulshizer RL, et al: Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality. .Cancer Genet Cytogenet 177::139. ,2007. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16

    Lambert I, Debiec-Rychter M, Guelinckx P, et al: Acral myxoinflammatory fibroblastic sarcoma with unique clonal chromosomal changes. .Virchows Arch 438::509. ,2001. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17

    Mansoor A, Fidda N, Himoe E, et al: Myxoinflammatory fibroblastic sarcoma with complex supernumerary ring chromosomes composed of chromosome 3 segments. .Cancer Genet Cytogenet 152::161. ,2004. .

    • Search Google Scholar
    • Export Citation
  • 18

    Lang JE, Dodd L, Martinez S, et al: Acral myxoinflammatory fibroblastic sarcoma. .Clin Orthop Relat Res 445::254. ,2006. .

  • 19

    Baumhoer D, Glatz K, Schulten HJ, et al: Myxoinflammatory fibroblastic sarcoma: investigations by comparative genomic hybridization of two cases and review of the literature. .Virchows Arch 451::923. ,2007. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20

    Alkuwari E, Gravel DH: A 30-year-old man with a soft tissue mass on the right elbow: inflammatory myxohyaline tumor of the distal extremities with prominent eosinophilic infiltrate. .Arch Pathol Lab Med 130::35. ,2006. .

    • Search Google Scholar
    • Export Citation
  • 21

    Ebhardt H, Kosmehl H, Katenkamp D: Acral myxoinflammatory fibroblastic sarcoma: six cases of a tumor entity [in German]. .Pathologe 22::157. ,2001. .

A Report of a Rare Case of Myxoinflammatory Fibroblastic Sarcoma

Antonio Córdoba-Fernández Podiatry, Seville University, Seville, Spain.

Search for other papers by Antonio Córdoba-Fernández in
Current site
Google Scholar
PubMed
Close
 DP, PhD
,
José María Juárez-Jiménez Podiatry, Seville University, Seville, Spain.

Search for other papers by José María Juárez-Jiménez in
Current site
Google Scholar
PubMed
Close
 DP, PhD
,
José Mazuecos-Blanca Podiatry, Seville University, Seville, Spain.

Search for other papers by José Mazuecos-Blanca in
Current site
Google Scholar
PubMed
Close
 MD, PhD
, and
Matilde Illanes-Moreno Podiatry, Seville University, Seville, Spain.

Search for other papers by Matilde Illanes-Moreno in
Current site
Google Scholar
PubMed
Close
 MD, PhD
Restricted access

Myxoinflammatory fibroblastic sarcoma of the soft tissues is a rare low-grade tumor of uncertain origin that most often occurs on the extremities of adults. The tumor predominantly involves the subcutaneous tissues of the hands and feet. Despite being a rare neoplasm, owing to its varied histologic appearance, myxoinflammatory fibroblastic sarcoma should be differentiated from various benign and malignant soft-tissue lesions. Myxoinflammatory fibroblastic sarcoma has been well described in pathology journals but not in the surgical literature. We report a case of myxoinflammatory fibroblastic sarcoma in a 19-year-old man with a plantar ulcer lesion in his left foot. To our knowledge, this is the first reported case in the literature involving the epidermis. (J Am Podiatr Med Assoc 100(6): 497–501, 2010)

Corresponding author: Antonio Cordoba, DP, PhD, Podiatry, Seville University, Avicena s/n, Seville, 41009 Spain. (E-mail: acordoba@us.es)