Sion-Vardy N, Manor E, Puterman M, et al: Solitary angiokeratoma of the tongue. .Med Oral Patol Oral Cir Bucal 13::E12. ,2008. .
Farooq U, Mirzabeigi M, Vincek V: Solitary angiokeratoma of the tongue. .Eur J Pediat Dermatol 15::233. ,2005. .
Zaballos P, Daufi C: Dermoscopy of solitary angiokeratomas: a morphological study. .Arch Dermatol 143::318. ,2007. .
Gomi H, Eriyama Y, Horikawa E, et al: Solitary angiokeratoma. .J Dermatol 15::349. ,1988. .
Meberg R, Kenyon E, Bierman R, et al: Characterization of plantar verrucae among individuals with human immunodeficiency virus. .JAPMA 88::442. ,1998. .
Watkins P: Identifying and treating plantar warts. .Nurs Stand 20::50. ,2006. .
Whitaker JM, Gaggero GL, Loveland L, et al: Plantar verrucae in patients with human immunodeficiency virus: clinical presentation and treatment response. .JAPMA 91::79. ,2001. .
Milkenny M, Merlin K, Young R, et al: The prevalence of common skin conditions in Australian school students: 1. Common, plane and plantar viral warts. .Br J Dermatol 138::840. ,1998. .
One of the more frequent pathologic conditions that podiatric physicians are confronted with is plantar verrucae. Plantar verrucae have been studied extensively in terms of morphological features and incidence in the population at large and in patients with human immunodeficiency virus infection. Solitary angiokeratomas can be morphologically similar to plantar verrucae, presenting as hyperkeratotic pedunculated lesions. We present a unique case study of a 40-year-old man with human immunodeficiency virus with a painful solitary angiokeratoma masquerading as plantar verrucae. The lesion demonstrated clinical signs consistent with those highlighted in the literature for verrucae, namely, showing as red and black lacunae, punctuated hyperkeratotic epidermis. We propose that solitary angiokeratomas should be an important part of a podiatric physician’s differential diagnosis in the lower extremity owing to the similarity of morphological features with plantar verrucae. (J Am Podiatr Med Assoc 100(6): 502–504, 2010)