• 1.

    Oh, SJ, AC Melo, DK Lee, et al. :Largefiber neuropathy in distal sensory neuropathy with normal routine nerve conduction. .Neurology 56::1570. ,2001. .

  • 2.

    Park, KS, SH Lee, KW Lee, et al. :Interdigital nerve conduction study of the foot for an early detection of diabetic sensory polyneuropathy. .Clin Neurophysiol 114::894. ,2003. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Singleton, JR. :Evaluation and treatment of painful peripheral polyneuropathy. .Semin Neurol 25::185. ,2005. .

  • 4.

    Killian, JM and PJ Foreman. :Clinical utility of dorsal sural nerve conduction studies. .Muscle Nerve 24::817. ,2001. .

  • 5.

    Loseth, S, M Nebuchennykh, E Stalberg, et al. :Medial plantar nerve conduction studies in healthy controls and diabetics. .Clin Neurophysiol 118::1155. ,2007. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Herrmann, DN, ML Ferguson, V Pannoni, et al. :Plantar nerve AP and skin biopsy in sensory neuropathies with normal routine conduction studies. .Neurology 63::879. ,2004. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Turgut, N, S Karasalihoglu, Y Kucukugurluoglu, et al. :Clinical utility of dorsal sural nerve conduction studies in healthy and diabetic children. .Clin Neurophysiol 115::1452. ,2004. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8.

    Mayer, RF. :Nerve conduction studies in man. .Neurology 13::1021. ,1963. .

  • 9.

    LaFratta, CW and A Zalis. :Age effects on sural nerve conduction velocity. .Arch Phys Med Rehabil 54::475. ,1973. .

  • 10.

    Dorfman, LJ and TM Bosley. :Age-related changes in peripheral and central nerve conduction in man. .Neurology 29::38. ,1979. .

  • 11.

    Trojaborg, WT, A Moon, BB Andersen, et al. :Sural nerve conduction parameters in normal subjects related to age, gender, temperature, and height: a reappraisal. .Muscle Nerve 15::666. ,1992. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Tong, HC, RA Werner, and A Franzblau. :Effect of aging on sensory nerve conduction study parameters. .Muscle Nerve 29::716. ,2004. .

  • 13.

    Falco, FJ, WJ Hennessey, G Goldberg, et al. :Standardized nerve conduction studies in the lower limb of the healthy elderly. .Am J Phys Med Rehabil 73::168. ,1994. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14.

    Buschbacher, RM. :Body mass index effect on common nerve conduction study measurements. .Muscle Nerve 21::1398. ,1998. .

  • 15.

    Oh, SJ. :Clinical Electromyography Nerve Conduction Studies, ,3rd Ed. ,Williams & Wilkins. ,Baltimore. ,2003. .

  • 16.

    Fu, R, JA DeLisa, and GH Kraft. :Motor nerve latencies through the tarsal tunnel in normal adult subjects: standard determinations corrected for temperature and distance. .Arch Med Phys Rehabil 61::243. ,1980. .

    • Search Google Scholar
    • Export Citation
  • 17.

    Park, TA and DR Del Toro. :The medial calcaneal nerve: anatomy and nerve conduction technique. .Muscle Nerve 18::32. ,1995. .

  • 18.

    Saeed, MA and PF Gatens. :Compound nerve action potentials of the medial and lateral plantar nerves through the tarsal tunnel. .Arch Med Phys Rehabil 68::304. ,1982. .

    • Search Google Scholar
    • Export Citation
  • 19.

    Oh, SJ, HS Kim, and BK Ahmad. :The near-nerve sensory nerve conduction in tarsal tunnel syndrome. .J Neurol Neurosurg Psychiatry 48::999. ,1985. .

  • 20.

    Schellens, RL, BK Van Veen, AA Gabreels-Festen, et al. :A statistical approach to fiber diameter distribution in human sural nerve. .Muscle Nerve 16::1342. ,1993. .

  • 21.

    Rivner, MH, TR Swift, and K Malik. :Influence of age and height on nerve conduction. .Muscle Nerve 24::1134. ,2001. .

  • 22.

    Stetson, DS, JW Albers, BA Silverstein, et al. :Effects of age, sex, and anthropometric factors on nerve conduction measures. .Muscle Nerve 15::1095. ,1992. .

  • 23.

    Ochoa, J and WG Mair. :The normal sural nerve in man: II. Changes in the axons and Schwann cells due to ageing. .Acta Neuropathol 13::217. ,1969. .

  • 24.

    Tohgi, H, H Tsukagoshi, and Y Toyokura. :Quantitative changes with age in normal sural nerves. .Acta Neuropathol 38::213. ,1977. .

  • 25.

    Fujimaki, Y, S Kuwabara, Y Sato, et al. :The effects of age, gender, and body mass index on amplitude of sensory nerve action potentials: multivariate analyses. .Clin Neurophysiol 120::1683. ,2009. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Saeed, S and M Arkam. :Impact of anthropmetric measures on sural nerve conduction in healthy subjects. :J Ayub Med Coll Abbottabad 20::112. ,2008. .

  • 27.

    Wilbourn, AJ. :Nerve conduction studies: types, components, abnormalities, and value in localization. .Neurol Clin 20::305. ,2002. .

  • 28.

    Thrainsdottir, S, RA Malik, I Ros, et al. :Sural nerve biopsy may predict future nerve dysfunction. .Acta Neurol Scand 120::38. ,2009. .

  • 29.

    Baron, AD. :Insulin resistance and vascular function. .J Diabetes Complications 16::92. ,2002. .

  • 30.

    Mather, KJ, B Mirzamohammadi, A Lteif, et al. :Endothelin contributes to basal vascular tone and endothelial dysfunction in human obesity and type 2 diabetes. .Diabetes 51::3517. ,2002. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    Tomic, M, T Poljicanin, I Pavlic-Renar, et al. :Obesity: a risk factor for microvascular and neuropathic complications in diabetes? Diabetol Croatia 32::73. ,2003. .

    • Search Google Scholar
    • Export Citation
  • 32.

    Ziegler, D, W Rathmann, T Dickhaus, et al. :Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3. .Diabetes Care 31::464. ,2008. .

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33.

    Solomon, OU, OO Mayowa, AU Tokunbo, et al. :The association between body mass index and diabetic peripheral neuropathy. .Hung Med J 2::63. ,2008. .

Effects of Anthropometric Factors on Nerve Conduction

An Electrophysiologic Study of Feet

View More View Less
  • 1 Department of Neurology, Faculty of Medicine, Maltepe University, Istanbul, Turkey.
  • | 2 Department of Orthopaedics and Traumatology, Faculty of Medicine, Maltepe University, Istanbul, Turkey.
Restricted access

Background:

Previous studies have shown that age, sex, and body mass index (BMI) affect the amplitude of sensory nerve action potentials (SNAPs), but the total effects of multiple factors and the most prominently affected nerves have not been elucidated. We systematically investigated the effects of these factors on motor and sensory nerves of the feet.

Methods:

The amplitude, latency, and conduction velocity of compound muscle action potential (CMAP), SNAP, and mixed nerve action potential (MNAP) of the posterior tibial, calcaneal, distal posterior tibial, medial and lateral plantar, and sural nerves were measured in 30 healthy individuals (60 feet). The effects of age, sex, height, and BMI on each nerve were estimated by correlation and linear regression analyses.

Results:

The amplitude of posterior tibial CMAP and distal posterior tibial MNAP decreased with BMI. The amplitude of medial plantar MNAP and sural SNAP decreased with height. The conduction velocity of calcaneal SNAP and distal posterior tibial and lateral plantar MNAP decreased with height and BMI. The conduction velocity of medial plantar MNAP decreased only with height. The latency of posterior tibial CMAP increased with age and height. The latency of lateral plantar CMAP and calcaneal SNAP increased with height. The latency of lateral plantar MNAP increased with BMI.

Conclusions:

The effects of age, sex, height, and BMI in foot nerve conduction studies are not identical. Height and BMI were shown to strongly affect motor, sensory, and mixed nerve conduction. Further investigations are needed. (J Am Podiatr Med Assoc 103(1): 43–49, 2013)

Corresponding author: Sibel Karsidag, MD, Department of Neurology, Faculty of Medicine, Maltepe University, Feyzullah Street, No. 39, Istanbul, Turkey 34843. (E-mail: karsidags@yahoo.com)