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-
1.
Naik CL, Singh G: Clinico epidemiological study of pitted keratolysis. Indian J Dermatol 52: 35, 2007.
-
2.
Kim B, Park K, Kim J, et al: Comparative study of benzoyl peroxide versus clindamycin phosphate in treatment of pitted keratolysis. Korean J Med Mycol 20: 144, 2005.
-
3.
Ertam I, Aytimur D, Yuksel SE: Isolation of Kytococcus sedentarius from a case of pitted keratolysis. Ege Tip Dergisi 44: 117, 2005.
-
4.
Takama H, Tamada Y, Yano K, et al: Pitted keratolysis: clinical manifestations in 53 cases. Br J Dermatol 137: 282, 1997.
-
5.
Ramsey ML: Pitted keratolysis: a common infection of active feet. Phys Sportsmed 24: 51, 1996.
-
6.
Blaise G, Nikkels A, Hermanns-Lê TF, et al: Corynebacterium associated skin infections. Int J Dermatol 47: 884, 2008.
-
7.
Nordstrom KM, McGinley KJ, Cappiello L, et al: Pitted keratolysis: the role of Micrococcus sedentarius. Arch Dermatol 123: 1320, 1987.
-
8.
Longshaw CM, Wright JD, Farrell AM, et al: Kytococcus sedentarius, the organism associated with pitted keratolysis, produces two keratin-degrading enzymes. J Appl Microbiol 93: 810, 2002.
-
9.
Woodgyer AJ, Baxter M, Rush-Munro FM, et al: Isolation of Dermatophilus congolensis from two New Zealand cases of pitted keratolysis. Australas J Dermatol 26: 29, 1985.
-
10.
de Almeida HL Jr, de Castro LA, Rocha NE, et al: Ultrastructure of pitted keratolysis. Int J Dermatol 39: 698, 2000.
-
11.
Tilgen W: Pitted keratolysis (keratolysis plantare sulcatum): ultrastructural study. J Cutan Pathol 6: 18, 1979.
-
12.
Hermanns-Le T, Garcia R, Arrese JE, et al: Pitted keratolysis: new ultrastructural insight in keratohyalin granule and corneodesmosome alterations. Exogenous Dermatol 3: 107, 2004.
-
13.
Vazquez-Lopez F, Perez-Oliva N: Mupirocine ointment for symptomatic pitted keratolysis. Infection 24: 55, 1996.
-
14.
Shenoi SD, Davis SV, Rao S, et al: Dermatoses among paddy field workers: a descriptive, cross-sectional pilot study. Indian J Dermatol Venereol Leprol 71: 254, 2005.
-
15.
Eun HC, Park HB, Chun YH: Occupational pitted keratolysis. Contact Dermatitis 12: 122, 1985.
-
16.
Wohlrab J, Rohrbach D, Marsch WC: Keratolysis sulcata (pitted keratolysis): clinical symptoms with different histological correlates. Br J Dermatol 143: 1348, 2000.
-
17.
Burkhart CG: Pitted keratolysis: a new form of treatment. Arch Dermatol 116: 1104, 1980.
-
18.
Colver G: Pitted keratolysis treated with 1% clindamycin phosphate. Br J Dermatol 137 (supp 50): 51, 1997.
-
19.
Tamura BM, Cuce LC, Souza RL, et al: Plantar hyperhidrosis and pitted keratolysis treated with botulinum toxin injection. J Dermatol Surg 30: 1510, 2004.
-
20.
Khachemoune A, Janjua SA: Pits on the soles of the feet. J Fam Pract 54: 597, 2005.
-
21.
Garcia Cuadros GR, Nunez del Prado YMF, Arrese Estrada J: Queratolisis punctata emergente en los Andes Cusco-Peru. Med Cutan Iber Lat Am 34: 223, 2006.
-
22.
Argomaniz EB, Castillo AT: Quaeratolisis plantar sulcatum. Form Med Contin Aten Primaria 14: 555, 2007.
-
23.
Vlahovic TC, Dunn SP, Kemp K: The use of a clindamycin 1%-benzoyl peroxide 5% topical gel in the treatment of pitted keratolysis: a novel therapy. Adv Skin Wound Care 22: 564, 2009.
-
24.
Kaptanoglu AF, Yuksel O, Ozyurt S: Plantar pitted keratolysis: a study from non-risk groups. Dermatol Rep 4: 14, 2012.
-
25.
Lamberg SI: Symptomatic pitted keratolysis. Arch Dermatol 100: 10, 1969.
-
26.
Zaias N: Pitted and ringed keratolysis: a review and update. J Am Acad Dermatol 7: 787, 1982.
-
27.
Lockwood LL, Gehrke S, Navarini AA: Dermoscopy of pitted keratolysis. Case Rep Dermatol 2: 146, 2010.
-
28.
Burkhart CG, Burkhart CN: Antibacterial properties of benzoyl peroxide in aerobic and anaerobic conditions. Int J Dermatol 45: 1373, 2006.
-
29.
Bikowski JB: Clinical experience results with clindamycin 1% benzoyl peroxide 5% gel (Duac) as monotherapy and in combination. J Drugs Dermatol 4: 164, 2005.
-
30.
Rennie RP: Susceptibility of Staphylococcus aureus to fusidic acid: Canadian data. J Cutan Med Surg 10: 277, 2006.
-
31.
Cookson BD: The emergence of mupirocin resistance: a challenge to infection control and antibiotic prescribing practice. J Antimicrob Chemother 41: 11, 1998.
-
32.
Marples R, Kligman A: Ecological effects of oral antibiotics on the microflora of human skin. Arch Dermatol 103: 148, 1972.
-
33.
Ya-Xian Z, Suetake T, Tagami H: Number of cell layers of the stratum corneum in normal skin: relationship to the anatomical location on the body, age, sex and physical parameters. Arch Dermatol Res 291: 555, 1999.
-
34.
Coyle MB, Lipsky BA: Coryneform bacteria in infectious diseases: clinical and laboratory aspects. Clin Microbiol Rev 3: 227, 1990.
-
35.
Weingarten-Arams J, Adam HM: Clindamycin. Pediatr Rev 23: 149, 2002.
-
36.
Weiss JW, Shavin J, Davis M: Preliminary results of a nonrandomized, multicenter, open-label study of patient satisfaction after treatment with combination benzoyl peroxide/clindamycin topical gel for mild to moderate acne. Clin Ther 24: 1706, 2002.
Pitted Keratolysis
A Clinical Review
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Background
Pitted keratolysis is a bacterial infection that affects the plantar epidermis. Despite the condition being reported in many countries affecting both shod and unshod populations, there is little guidance for clinicians providing evidence or best practice guidelines on the management of this often stubborn infection.
Methods
Using a structured search of a range of databases, papers were identified that reported treatments tested on patients with the condition.
Results
Most of the literature uncovered was generally of a low level, such as case-based reporting or small case series. Studies were focused mainly on the use of topical antibiotic agents, such as clindamycin, erythromycin, fusidic acid, and mupirocin, often in combination with other measures, such as hygiene advice and the use of antiperspirants. From the limited evidence available, the use of topical antibiotic agents shows some efficacy in the treatment of pitted keratolysis. However, there is currently no suggestion that oral antibiotic drug therapy alone is effective in managing the condition.
Conclusions
Currently, there is no consensus on the most effective approach to managing pitted keratolysis, but a combination of antimicrobial agents and adjunctive measures, such as antiperspirants, seems to demonstrate the most effective approach from the current literature available.
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