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-
1
Verocay J: Zur Kenntnis der “Neurofibrome.” Beitr Pathol Anat 48: 60, 1910.
-
2
Masson P: Recklinghausen's Neurofibromatosis, Sensory Neuromas and Motor Neuromas, Vol 2, p 793, International Press, New York, 1932.
-
3
Pasternack WA, Winter-Reiken DJ: Unusually large cellular schwannoma of the foot. JAPMA 95: 157, 2005.
-
4
Ritter SE, Elston DM: Cutaneous schwannoma of the foot. Cutis 67: 127, 2001.
-
5
Requena L, Sangueza OP: Benign neoplasms with neural differentiation: a review. Am J Dermatopathol 17: 75, 1995.
-
6
Kransdorf MJ: Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR Am J Roentgenol 164: 395, 1995.
-
7
Liebau C, Baltzer AW, Schneppenheim M, et al: Isolated peripheral neurilemoma attached to the tendon of the flexor digitorum longus muscle. Arch Orthop Trauma Surg 123: 98, 2003.
-
8
Ruggieri M: The different forms of neurofibromatosis. Childs Nerv Syst 15: 295, 1999.
-
9
Murray AJ, Hughes TA, Neal JW, et al: A case of multiple cutaneous schwannomas: schwannomatosis or neurofibromatosis type 2? J Neurol Neurosurg Psychiatry 77: 269, 2006.
-
10
Izumi AK, Rosato FE, Wood MG: Von Recklinghausen's disease associated with multiple neurolemomas. Arch Dermatol 104: 172, 1971.
-
11
Kluwe L, Friedrich RE, Hagel C, et al: Mutations and allelic loss of the NF2 gene in neurofibromatosis 2-associated skin tumors. J Invest Dermatol 114: 1017, 2000.
-
12
Jacobson GF, Edwards MC Jr: Neurilemoma presenting as a painless mass on the dorsum of the foot. JAPMA 83: 228, 1993.
-
13
Jacobson JM, Felder JM 3rd, Pedroso F, et al: Plexiform schwannoma of the foot: a review of the literature and case report. J Foot Ankle Surg 50: 68, 2011.
-
14
Carvajal JA, Cuartas E, Qadir R, et al: Peripheral nerve sheath tumors of the foot and ankle. Foot Ankle Int 32: 163, 2011.
-
15
Milnes HL, Pavier JC: Schwannoma of the tibial nerve sheath as a cause of tarsal tunnel syndrome: a case study. Foot (Edinb) 22: 243, 2012.
-
16
Kwok KB, Lui TH, Lo WN: Neurilemmoma of the first branch of the lateral plantar nerve causing tarsal tunnel syndrome. Foot Ankle Spec 2: 287, 2009.
-
17
Mangrulkar VH, Brunetti VA, Gould ES, et al: Unusually large pedal schwannoma. J Foot Ankle Surg 46: 398, 2007.
-
18
Nath AK, Sanmarkan AD, D'Souza M, et al: Non-healing ulcer on the great toe due to cellular schwannoma. Clin Exp Dermatol 34: e904, 2009.
-
19
Oçgüder A, Uğurlu M, Tecimel O, et al: [A case of ancient schwannoma of the great toe]. Acta Orthop Traumatol Turc 42: 382, 2008.
-
20
Nawabi DH, Sinisi M: Schwannoma of the posterior tibial nerve: the problem of delay in diagnosis. J Bone Joint Surg Br 89: 814, 2007.
-
21
DeBella K, Szudek J, Friedman JM: Use of the national institutes of health criteria for diagnosis of neurofibromatosis 1 in children. Pediatrics 105: 608, 2000.
-
22
Baser ME, Friedman JM, Joe H, et al: Empirical development of improved diagnostic criteria for neurofibromatosis 2. Genet Med 13: 576, 2011.
-
23
Westhout FD, Mathews M, Paré LS, et al: Recognizing schwannomatosis and distinguishing it from neurofibromatosis type 1 or 2. J Spinal Disord Tech 20: 329, 2007.
-
24
Sharma S, Sarkar C, Mathur M, et al: Benign nerve sheath tumors: a light microscopic, electron microscopic and immunohistochemical study of 102 cases. Pathology 22: 191, 1990.
-
25
Sachdev R, Singhal N, Mandal AK: Congenital fibrosarcoma of the upper extremity: a case report and review of literature. Indian J Pathol Microbiol 48: 474, 2005.
-
26
Yamamoto T, Minami R: Epithelioid leiomyosarcoma of the external deep soft tissue. Arch Pathol Lab Med 126: 468, 2002.
-
27
Mott RC, Dellon AL: Multiple schwannomas of the foot. Case report and strategy for treatment. JAPMA 93: 51, 2003.
Schwannoma of the Left Foot
A Brief Overview with Focus on Associated Clinical Syndromes
SUNY Downstate and Veterans Affairs Hospital, Dermatology Service, Mohs Micrographic Surgery and Dermatopathology, Brooklyn, NY.
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In this article, we present a 25-year-old man who developed an asymptomatic schwannoma on his left lateral heel and review the salient features of this cutaneous condition. A schwannoma is a slowly growing neoplasm of Schwann cell origin. Histology shows high cellularity (Antoni A regions), nuclear palisades (Verocay bodies), and alternating myxoid regions (Antoni B regions). Very few cases have been reported on the foot or ankle. As with this patient, most schwannomas do not cause symptoms, but some result in dysesthesia and nerve dysfunction. Multiple schwannomas may indicate an underlying syndrome such as neurofibromatosis type 1, type 2, and schwannomatosis. The differential diagnosis for schwannoma includes fibrosarcoma, leiomyosarcoma, and neurofibroma. The definitive treatment is surgical excision. This usually results in complete resolution with minimal recurrence, as was the case for this patient.
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