• 1

    Jones FE, Soule EH, Coventry MB: Fibrous xanthoma of synovium (giant cell tumour of tendon sheath, pigmented nodular synovitis): a study of one hundred and eighteen cases. J Bone Joint Surg Am 51: 76, 1969.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Cavaliere A, Sidoni A, Bucciarelli E: Giant cell tumour of tendon sheath: immunohistochemical study of 20 cases. Tumori 83: 841, 1997.

  • 3

    Gehweiler JA, Wilson JW: Diffuse biarticular pigmented villonodular synovitis. Radiology 93: 845, 1969.

  • 4

    Kotwal PP, Gupta V, Malhotra R: Giant-cell tumour of the tendon sheath: is radiotherapy indicated to prevent recurrence after surgery? J Bone Joint Surg Br 82: 571, 2000.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5

    Horvath RR, Bostanche J, Altman MI: Diffuse type tenosynovial giant cell tumor of the ankle. JAPMA 83: 231, 1993.

  • 6

    Demouy EH, Kaneko K, Bear HM, et al: Giant cell tumor of the plantar tendon sheath: role of MR imaging in diagnosis: case report. Clin Imaging 17: 153, 1993.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Monaghan H, Salter DM, Al-Nafussi A: Giant cell tumor of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases. J Clin Pathol 54: 404, 2001.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8

    Rodrigues C, Desai S, Chinoy R: Giant cell tumor of the tendon sheath: a retrospective study of 28 cases. J Surg Oncol 68: 100, 1998.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9

    Rao AS, Vigorita VJ: Pigmented villonodular synovitis (giant-cell tumour of the tendon sheath and synovial membrane): a review of eighty-one cases. J Bone Joint Surg Am 66: 76, 1984.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10

    Byers VS, Levin AS, Johnston JO, et al: Quantitative immunofluorescence studies of the tumour antigen-bearing cell in giant cell tumour of bone and osteogenic sarcoma. Cancer Res 35: 2520, 1975.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11

    Loréa P, Van De Walle H, Kinnen L, et al: Giant cell tumours of the tendon sheath: lack of correlation between nm23-H1 expression and recurrence. J Hand Surg Br 29: 67, 2004.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Al-Qattan MM: Giant cell tumours of tendon sheath: classification and recurrence rate. J Hand Surg Br 26: 72, 2001.

  • 13

    Grover R, Grobbelaar AO, Richman PI, et al: Measurement of invasive potential provides an accurate prognostic marker for giant cell tumour of tendon sheath. J Hand Surg Br 23: 728, 1998.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14

    Wakely PE Jr, Frable WJ: Fine-needle aspiration biopsy cytology of giant-cell tumor of tendon sheath. Am J Clin Pathol 102: 87, 1994.

  • 15

    Bisbinas I, De Silva U, Grimer RJ: Pigmented villonodular synovitis of the foot and ankle: a 12 year experience from a tertiary orthopedic oncology unit. J Foot Ankle Surg 43: 407, 2004.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16

    Martin RC II, Osborne DL, Edwards MJ, et al: Giant cell tumour of tendon sheath, tenosynovial giant cell tumour, and pigmented villonodular synovitis: defining the presentation, surgical therapy and recurrence. Oncol Rep 7: 413, 2000.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17

    Segler CP: Irradiation as adjunctive treatment of diffuse pigmented villonodular synovitis of the foot and ankle prior to tumor surgical excision. Med Hypotheses 61: 229, 2003.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18

    Lo EP, Ketterer D: Giant cell tumor of tendon sheath in the toe. JAPMA 90: 270, 2000.

  • 19

    Jaffe KA, Jones FK: “Foot Tumours,” in Operative Foot Surgery, edited by JS Gould, p 249, WB Saunders Co, Philadelphia, 1994.

  • 20

    Blay JY, El Sayadi H, Thiesse P, et al: Complete response to imatinib in relapsing pigmented villonodular synovitis/ tenosynovial giant cell tumor (PVNS/TGCT). Ann Oncol 19: 821, 2008.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21

    Frankel SL, Chioros PG, Sidlow CJ: Giant cell tumor of the plantar fascia: a case report. JAPMA 77: 557, 1987.

  • 22

    Butler BW, McCarty JM, Danforth RD Jr: Benign giant cell tumor of the foot. J Foot Ankle Surg 32: 299, 1993.

  • 23

    Ushijima M, Hashimoto H, Tsuneyoshi M, et al: Giant cell tumor of the tendon sheath (nodular tenosynovitis): a study of 207 cases to compare the large joint group with the common digit group. Cancer 57: 875, 1986.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24

    Gold AG, Bronfman RA, Clark EA, et al: Giant cell tumor of the extensor tendon sheath of the foot: a case report. JAPMA 77: 561, 1987.

  • 25

    Paez H, Vuletin JC, Soave RL, et al: Pedal giant cell tumor of tendon sheath. JAPMA 89: 368, 1999.

  • 26

    Ciattaglia G, Filosa G, Bugatti L: Giant cell tumor of tendon sheath. J Am Acad Dermatol 25: 728, 1991.

  • 27

    Muramatsu K, Mine T, Ichihara K: Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. JAPMA 96: 359, 2006.

  • 28

    Villani C, Tucci G, Di Mille M, et al: Extra-articular localized nodular synovitis (giant cell tumor of tendon sheath origin) attached to the subtalar joint. Foot Ankle Int 17: 413, 1996.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29

    Kuo CL, Yang SW, Chou YJ, et al: Giant cell tumor of the EDL tendon sheath: an unusual cause of hallux valgus. Foot Ankle Int 29: 534, 2008.

  • 30

    Findling J, Lascola NK, Groner TW: Giant cell tumor of the flexor hallucis longus tendon sheath: a case study. JAPMA 101: 187, 2011.

  • 31

    Adams EL, Yoder EM, Kasdan ML: Giant cell tumor of the tendon sheath: experience with 65 cases. Eplasty 12: e50, 2012.

  • 32

    Wang C-W, Chen C-Y, Wu K: Giant cell tumor of the tendon sheath causing tarsal tunnel syndrome: a case report. Formosan J Musculoskelet Disord 2: 75, 2011.

  • 33

    Zhang Y, Huang J, Ma X, et al: Giant cell tumor of the tendon sheath in the foot and ankle: case series and review of the literature. J Foot Ankle Surg 52: 24, 2013.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34

    Persad IJ, Rajan DT: Giant cell tumour of tendon sheath origin at the sinus tarsi. The Foot 14: 219, 2004.

  • 35

    Edwards DLA, Ahuja SA, Newington DPA: Giant cell tumour of tendon sheath. The Foot 10: 46, 2000.

  • 36

    Fadel ME, Schulz A, Linker R: Giant cell tumour of the tendon sheath in the foot. Foot Ankle Surg 12: 33, 2006.

  • 37

    Guryel E, Coleridge S, Bendall S: Unusual presentation of a giant cell tumor of the tendon sheath in the foot. J Surg Orthop Adv 13: 110, 2004.

  • 38

    Xie M, Xiao K, Fang ZH, et al: Giant cell tumour of the tendon sheath of the toe. Orthop Surg 3: 211, 2011.

  • 39

    Vasconez HC, Nisanci M, Lee EY: Giant cell tumour of the flexor tendon sheath of the foot. J Plast Reconstr Aesthet Surg 61: 815, 2008.

  • 40

    Gibbons CL, Khwaja HA, Cole AS, et al: Giant-cell tumour of the tendon sheath in the foot and ankle. J Bone Joint Surg Br 84: 1000, 2002.

Giant Cell Tumor of the Tendon Sheath Around the Foot and Ankle

A Report of Three Cases and a Literature Review

Gauresh Vargaonkar Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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Vikramadittya Singh Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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Sumit Arora Department of Orthopaedic Surgery, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, India.

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Abhishek Kashyap Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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Vikas Gupta Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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Geetika Khanna Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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Ramesh Kumar Central Institute of Orthopaedics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

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The foot and ankle are rare sites of involvement for giant cell tumor of tendon sheath. We present three rare cases of giant cell tumor of tendon sheath arising from the tendon sheaths of the flexor hallucis longus, peroneus brevis, and extensor hallucis brevis tendons, along with a literature review of such cases in the foot and ankle region. All of the patients were treated with surgical excision of the mass and were asymptomatic after minimum follow-up of 18 months. Giant cell tumor of tendon sheath involving the foot and ankle region is a rare clinical entity, and good results can be expected after surgical excision.

Corresponding author: Sumit Arora, MS(Ortho), DNB(Ortho), MNAMS, Department of Orthopaedic Surgery, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, 110002, India. (E-mail: mamc_309@yahoo.co.in)
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