Kyrle J: Hyperkeratosis follicularis et parafollicularis in cutem penetrans. Arch Dermatol Syphilol 123: 466, 1916.
Patterson JW, Richmond VA: The perforating disorders. J Am Acad Dermatol 10: 561, 1984.
Morton C, Henderson I, Jones M, et al: Acquired perforating dermatosis in a British dialysis population. Br J Dermatol 135: 671, 1996.
Kimmel M, Alscher DM, Dunst R, et al: The role of micro-inflammation in the pathogenesis of uraemic pruritus in haemodialysis patients. Nephrol Dial Transplant 21: 749, 2006.
Kasiakou S, Peppas G, Kapaskelis A, et al: Regression of skin lesions of Kyrle's disease with clindamycin: implications for an infectious component in the etiology of the disease. J Infect 50: 412, 2005.
Constantine VS, Carter VH: Kyrle's disease: II. Histopathologic findings in five cases and review of the literature. Arch Dermatol 97: 633, 1968.
Cunningham SR, Walsh M, Matthews R, et al: Kyrle's disease. J Am Acad Dermatol 16: 117, 1987.
Brazzini B, Pimpinelli N: New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. Am J Clin Dermatol 3: 47, 2002.
Hengge U, Ruzicka T, Schwatz R, et al: Adverse effects of topical glucocorticosteroids. J Am Acad Dermatol 54: 1, 2006.
We report two cases of biopsy-confirmed Kyrle disease. Kyrle disease is one of the perforating dermatoses associated with diabetic patients undergoing renal dialysis. In this report, we describe the clinical and histopathologic features, the differential diagnoses, and successful treatment of this unusual disorder.