Linker CA: “Blood,” in Current Medical Diagnosis and Treatment, 44th Ed, edited by LM Tierney, SJ McPhee, MA Papadakis, p 1590, McGraw-Hill, New York, 2005.
Palraj B, Paturi A, Stone R, et al: Soft tissue anaplastic large T-cell lymphoma associated with a metallic orthopedic implant: case report and review of the current literature. J Foot Ankle Surg 49: 561, 2010.
Skorman SE, Martin R: Primary lymphoma of the calcaneus with recurrence in the distal tibia: a case report. J Foot Ankle Surg 38: 278, 1999.
Mendeszoon MJ, Wire KR: Diffuse large B-cell lymphoma of the ankle: a case study of surgical intervention and outcome. JAPMA 100: 505, 2010.
Dodson NB, Mendicino RW, Catanzariti AR, et al: A diagnosis of marginal zone lymphoma following surgical correction of hallux abductovalgus: a case report. J Foot Ankle Surg 48: 125, 2009.
DeFronzo D, Saffran B: A unique presentation of non-Hodgkin's lymphoma in the foot. J Foot Surg 31: 112, 1992.
Singh DP, Dhillon MS, Sur RK, et al: Primary lymphoma of the bones of the foot: management of two cases. Foot Ankle 11: 324, 1991.
Ramanujam CL, Lakhani S, Derk F, et al: Cutaneous non-Hodgkin's lymphoma of the foot: a rare case report. J Foot Ankle Surg 48: 581, 2009.
Nickisch F, Tashjian RZ, Ritter M, et al: Primary malignant non-Hodgkin lymphoma of the talus: a case report. Foot Ankle Int 26: 568, 2005.
Longo DL: “Oncology and Hematology,” in Harrison's Principles of Internal Medicine, 15th Ed, Vol 1, edited by E Braunwald, AS Fauci, DL Kasper, et al, p 491, McGraw-Hill, New York, 2001.
Aster J, Kumar V: “White Cells, Lymph Nodes, Spleen, and Thymus,” in Robbin's Pathologic Basis of Disease, 6th Ed, edited by RS Cotran, V Kumar, T Collins, p 653, WB Saunders Co, Philadelphia, 1999.
Deasi KR, Pezner RD, Lipsett JA, et al: Total skin electron irradiation for mycosis fungoides: relationship between acute toxicities and measured dose at different anatomic sites. Int J Radiat Oncol Biol Phys 15: 641, 1988.
Phillips AA, Owens C, Lee S, et al: An update on the management of peripheral T-cell lymphoma and emerging treatment options. J Blood Med 2: 119, 2011.
Anderson JR, Armitage JO, Weisenburger DD: Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Ann Oncol 7: 717, 1998.
Jaffe ES: The 2008 WHO classification of lymphomas: implications for clinical practice and translational research. Hematology Am Soc Hematol Educ Program 523, 2009.
Schmitz N, Trumper L, Ziepert M, et al: Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group. Blood 116: 3418, 2010.
Carbone PP, Kaplan HS, Musshoff, K et al: Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res 31: 1860, 1971.
Cutaneous T-cell lymphoma is a type of non-Hodgkin's lymphoma, which is a neoplasm affecting the lymphatic system. Mycosis fungoides is the most common subset of cutaneous T-cell lymphoma and is often treated conservatively. This neoplasm is most common in adults older than 60 years and does not regularly manifest in the toes. A case is reported of a 70-year-old man seen for a nonhealing hallux ulceration leading to amputation. Histopathologic examination revealed a rare transformed CD30+ high-grade cutaneous T-cell lymphoma. The morbidity of lymphomas is highly dependent on type and grade. Pharmaceutical precision therapies exist that target specific molecular defects or abnormally expressed genes, such as high expression of CD30. This article focuses on treatment protocol and emphasizes the importance of early diagnosis, determination of cell type, and proper referral of atypical dermatologic lesions.