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Multiple Eccrine Syringofibroadenoma of Mascaro of the Lower Extremity

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  • 1 Department of Surgery, Cleveland VA Medical Center, Cleveland, OH.
  • | 2 Young Physicians' Program, American Podiatric Medical Association, Bethesda, MD. Dr. Salvo is now with the Podiatry Section and Podiatry Residency Program, Atlanta VA Medical Center, Decatur, GA.
  • | 3 University of Pittsburgh Medical Center, Erie, PA.
  • | 4 Private practice, Schwein Foot & Ankle Clinic, Mansfield, OH.
  • | 5 Kent State University College of Podiatric Medicine, Independence, OH.
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Eccrine syringofibroadenoma (ESFA) is a rare benign lesion of ductal and secretory differentiation exhibiting multiple cutaneous polymorphic presentations with an unknown etiology. We present a case of ESFA that uniquely exhibited large, thick, verrucous-like hyperplastic growths as well as superficial shiny mosaic plaques and deep ulcerations in three different anatomical locations in the same patient. The diagnosis of ESFA was confirmed histologically after biopsies were performed on all of the affected areas. In addition to a case report and literature review, we also present classification, clinical, and histologic aspects of ESFA.

Corresponding author: Danae L. Lowell, DPM, Department of Surgery, Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106. (E-mail: danae.lowell@va.gov)