• 1

    Chayakulkeeree M, Perfect JR: “Cryptococcosis,” in Infectious Disease: Diagnosis and Treatment of Human Mycoses , edited by DR Hospenthal, MG Rinaldi, p 255, Humana Press Inc, Totowa, NJ, 2008.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 2

    Balaji GG, Mathuram AJ, Arockiaraj J, et al: A rare case of cryptococcal infection of talus with pathological fracture that healed with medical management. J Foot Ankle Surg 50: 740, 2011.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 3

    Li SS, Mody CH: Cryptococcus. Proc Am Thorac Soc 7: 186, 2010.

  • 4

    Bullogh PG: “Bone and Joint Infection,” in Bullogh and Vigoritta's Orthopaedic Pathology, 3rd Ed, p 126, Mosby-Wolfe, London, 1997.

  • 5

    Zainal AI, Wong SL, Pan KL, et al: Cryptococcal osteomyelitis of the femur: a case report and review of literature. Trop Biomed 28: 444, 2011.

  • 6

    Gurevitz O, Goldschmied-Reuven A, Block C, et al: Cryptococcus neoformans vertebral osteomyelitis. J Med Vet Mycol 32: 315, 1994.

  • 7

    McClelland EE, Casadevall A, Eisenman HC: “Pathogenesis of Cryptococcus Neoformans,” in New Insight in Medical Mycolog y, p 130, Springer, Dordrecht, the Netherlands, 2007.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8

    Zhang Y, Yu YS, Tang ZH, et al: Cryptococcal osteomyelitis of the scapula and rib in an immunocompetent patient. Med Mycol 50: 751, 2012.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 9

    Behrman RE, Masci JR, Nicholas P: Cryptococal skeletal infections: case report and review. Rev Infect Dis 12: 181, 1990.

  • 10

    Al-Tawfiq JA, Ghandour J: Cryptococcus neoformans abscess and osteomyelitis in an immunocompetent patient with tuberculous lymphadenitis. Infection 35: 377, 2007.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 11

    Perfect JR, Dismukes WE, Dromer F, et al: Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 50: 291, 2010.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 12

    Corral JE, Lima S, Quezada J, et al: Cryptococcal osteomyelitis of the skull. Med Mycol 49: 667, 2011.

    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 13

    Bariteau JT, Waryasz GR, McDonnell M, et al: Fungal osteomyelitis and septic arthritis. J Am Acad Orthop Surg 22: 390, 2014.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 14

    Geller DS, Pope JB, Thornhill BA, et al: Cryptococcal pyarthrosis and sarcoidosis. Skeletal Radiol 38: 721, 2009.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 15

    Ettahar N, Legout L, Ajana F, et al: Cryptococcal osteomyelitis in a patient with a lymphocytic leukemia treated with fludarabine-cyclophosphamide-rituximab [in French]. J Mycol Med 23: 57, 2013.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16

    Gosling HR, Gilmer WS Jr: Skeletal cryptococcosis (torulosis): report of a case and review of the literature. J Bone Joint Surg Am 38: 660, 1956.

  • 17

    Chleboun J, Nade S: Skeletal cryptococcosis. J Bone Joint Surg Am 59: 509, 1977.

  • 18

    Witte DA, Chen I, Brady J, et al: Cryptococcal osteomyelitis: report of a case with aspiration biopsy of a humeral lesion with radiologic features of malignancy. Acta Cytol 44: 815, 2000.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19

    Chang WC, Tzao C, Hsu HH, et al: Isolated cryptococcal thoracic empyema with osteomyelitis of the rib in an immunocompetent host. J Infect 51: e117, 2005.

  • 20

    Liu PY: Cryptococcal osteomyelitis: case report and review. Diagn Microbiol Infect Dis 30: 33, 1998.

Cryptococcal Osteomyelitis of the First Metatarsal Head in an Immunocompetent Patient

A Case Report

Jae Hoon Ahn Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Search for other papers by Jae Hoon Ahn in
Current site
Google Scholar
PubMed
Close
 MD, PhD
,
ChanJoo Park Department of Orthopaedic Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Paldal-gu, Suwon-si, Gyeonggi-do, Republic of Korea.

Search for other papers by ChanJoo Park in
Current site
Google Scholar
PubMed
Close
 MD
,
Choong Woo Lee Department of Orthopaedic Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Paldal-gu, Suwon-si, Gyeonggi-do, Republic of Korea.

Search for other papers by Choong Woo Lee in
Current site
Google Scholar
PubMed
Close
 MD
, and
Yoon-Chung Kim Department of Orthopaedic Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Paldal-gu, Suwon-si, Gyeonggi-do, Republic of Korea.

Search for other papers by Yoon-Chung Kim in
Current site
Google Scholar
PubMed
Close
 MD, PhD

Most fungal infections primarily occur in immunocompromised patients. We describe a case of osteomyelitis involving the first metatarsal head due to Cryptococcus neoformans in a previously healthy immunocompetent patient. She was treated with surgical debridement combined with antifungal drug therapy for 6 months. At 5-year follow-up, she remained symptom free with full range of motion of the first metatarsophalangeal joint. Fungal osteomyelitis should be considered as a possible cause in osteolytic lesions in the metatarsal bone.

Corresponding author: Yoon-Chung Kim, MD, PhD, Department of Orthopaedic Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Jungbu-daero 93, Paldal-gu, Suwon-si, Gyeonggi-do 16247, Republic of Korea. (E-mail: cruzinbooo@catholic.ac.kr)
Save