Alonso P, Rouse MS, Piper KE, et al: Comparative study of antimicrobial release kinetics from polymethylmethacrylate. Clin Orthop Relat Res 445: 239, 2006.
Nelson CL, Hickman SG, Harrison BH: Elusion characteristics of gentamycin-PMMA beads after implantation in humans. Orthopedics 17: 415, 1994.
Perry AC, Rouse MS, Khaliq Y, et al: Antimicrobial release kinetics from polymethylmethacrylate in a novel continuous flow chamber. Clin Orthop Relat Res 403: 49, 2002.
Wahlig H, Dingeldein E, Bergman R, et al: The release of gentamycin from polymethylmethacrylate beads: an experimental and pharmacokinetic study. J Bone Joint Surg Br 60: 270, 1978.
Karr JC: Management of a diabetic patient presenting with forefoot osteomyelitis: the use of Ceramentâ„¢ |bone void filler impregnated with vancomycin: an off label use. J Diabetic Foot Complications 1: 94, 2009.
Karr JC: Management in the wound-care center outpatient setting of a diabetic patient with forefoot osteomyelitis using Cerament Bone Void Filler impregnated with vancomycin: off-label use. JAPMA 101: 259, 2011.
McKee MD, Wild LM, Schemitsch EM, et al: The use of an antibiotic-impregnated, osteconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Surg 16: 622, 2002.
Moore WR, Graves SE, Baind GI: Syntheic bone graft substitutes. Anz J Surg 71: 354, 2001.
Klessig HT, Showsh SA, Sekorski AS: The use of intradiscal antibiotic for discography: an in vitro study of gentamycin, cefazolin, and clindamycin. Spine 28: 1735, 2003.
Boyer GW, Cumberland N: Antibiotic release from impregnated pellets and beads. J Trauma 36: 331, 1994.
Turner TM, Urban RM, Gitelis S, et al: Radiographic and histological assessment of calcium sulfate in experimental animal models and clinical use as a resorbable bone-graft substitute, a bone-graft expander, and a method for local antibiotic delivery. J Bone Joint Surg Am 83: 8, 2001.
Yamashita Y, Uchida A, Yamakawa T, et al: Treatment of chronic osteomyelitis using calcium hydroxyapatite ceramic implants impregnated with antibiotic. Int Orthop 22: 247, 1998.
Cornell CN, Tyndall D, Waller S, et al: Treatment of experimental osteomyelitis with antibiotic-impregnated bone graft substitute. J Orthop Res 11: 619, 1993.
Mallin M, Wang JS, Wielanek L: Biodegradation and biocompatibility of a calcium sulphate-hydroxyapatite bone substitute. J Bone Joint Surg Br 86: 120, 2004.
Karr JC, Keriazes G, Lautetta J: In vitro antimicrobial activity of calcium sulfate and hydroxyapatite (Cerament Bone Void Filler) discs utilizing heat sensitive and heat non-sensitive antibiotics against methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. JAPMA 101: 146, 2011.
Tetsworth K, Cierny G III: Osteomyelitis debridement techniques. Clin Orthop Relat Res 360: 87, 1999.
A percutaneous antibiotic delivery technique (PAD-T) used for the adjunctive management of osteomyelitis is presented.
This surgical technique incorporates a calcium sulfate and hydroxyapatite (calcium phosphate) bone void filler acting as a carrier vehicle with either an antibiotic or an antifungal medicine, delivering this combination directly into the area of osteomyelitis.
The benefit of the PAD-T is reviewed with a case presentation of a successfully treated calcaneal osteomyelitis.
No previously reported PAD-T using a simple bone cortex incision in the adjunctive treatment of osteomyelitis has been reported. The PAD-T safely and effectively uses a calcium sulfate and hydroxyapatite bone void filler carrier vehicle to deliver either an antibiotic or an antifungal medicine directly into the area of osteomyelitis.