• 1

    Driver VR, Fabbi M, Lavery LA, et al: The costs of diabetic foot: the economic case for the limb salvage team. J Vasc Surg 52(3 Suppl):17S, 2010.

  • 2

    van Acker K, Leger P, Hartemann A, et al: Burden of diabetic foot disorders, guidelines for management and disparities in implementation in Europe: a systematic literature review. Diabetes Metab Res Rev 30: 635, 2014.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3

    Emery CF, Kiecolt-Glaser JK, Glaser R, et al: Exercise accelerates wound healing among healthy older adults: a preliminary investigation. J Gerontol A Biol Sci Med Sci 60: 1432, 2005.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4

    Pence BD, Woods JA: Exercise, obesity, and cutaneous wound healing: evidence from rodent and human studies. Adv Wound Care (New Rochelle) 3: 71, 2014.

  • 5

    Goh J, Ladiges WC: Exercise enhances wound healing and prevents cancer progression during aging by targeting macrophage polarity. Mech Ageing Dev 139: 41, 2014.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6

    Colberg SR, Albright AL, Blissmer BJ, et al: Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: joint position statement. Exercise and type 2 diabetes. Med Sci Sports Exerc 42: 2282, 2010.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Brazeau AS, Leroux C, Mircescu H, et al: Physical activity level and body composition among adults with type 1 diabetes. Diabet Med 29: e402, 2012.

  • 8

    Yardley JE, Hay J, Abou-Setta AM, et al: A systematic review and meta-analysis of exercise interventions in adults with type 1 diabetes. Diabetes Res Clin Pract 106: 393, 2014.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9

    Wu SC, Crews RT, Armstrong DGA: The pivotal role of offloading in the management of neuropathic foot ulceration. Curr Diab Rep 5: 423, 2005.

  • 10

    Alavi A, Sibbald RG, Mayer D, et al: Diabetic foot ulcers: Part I. Pathophysiology and prevention. J Am Acad Dermatol 70: e1 [quiz 19-20], 2014.

  • 11

    Katz IA, Harlan A, Miranda-Palma B, et al: A randomized trial of two irremovable off-loading devices in the management of plantar neuropathic diabetic foot ulcers. Diabetes Care 28: 555, 2005.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Armstrong DG, Nguyen HC, Lavery LA, et al: Off-loading the diabetic foot wound: a randomized clinical trial. Diabetes Care 24: 1019, 2001.

  • 13

    Fleischli JG, Lavery LA, Vela SA, et al: 1997 William J. Stickel Bronze Award. Comparison of strategies for reducing pressure at the site of neuropathic ulcers. JAPMA 87: 466, 1997.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14

    Crews RT, Sayeed F, Najafi B: Impact of strut height on offloading capacity of removable cast walkers. Clin Biomech (Bristol, Avon) 27: 725, 2012.

  • 15

    Goodworth AD, Kunsman M, DePietro V, et al: Characterization of how a walking boot affects balance. J Prosthet Orthot 26: 54, 2014.

  • 16

    Pinzur M, Freeland R, Juknelis D: The association between body mass index and foot disorders in diabetic patients. Foot Ankle Int 26: 375, 2005.

  • 17

    Advani A, Marshall SM, Thomas TH: Impaired neutrophil actin assembly causes persistent CD11b expression and reduced primary granule exocytosis in Type II diabetes. Diabetologia 45: 719, 2002.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18

    Drerup B, Beckmann C, Wetz HH: [Effect of body weight on plantar peak pressure in diabetic patients]. Orthopade 32: 199, 2003.

  • 19

    Vela SA, Lavery LA, Armstrong DG, et al: The effect of increased weight on peak pressures: implications for obesity and diabetic foot pathology. J Foot Ankle Surg 37: 416, 1998, discussion 448-9.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20

    Sigal RJ, Kenny GP, Boule NG, et al: Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 147: 357, 2007.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21

    Williams DT, Harding KG, Price PE: The influence of exercise on foot perfusion in diabetes. Diabet Med 24: 1105, 2007.

  • 22

    Colberg SR, Parson HK, Holton DR, et al: Cutaneous blood flow in type 2 diabetic individuals after an acute bout of maximal exercise. Diabetes Care 26: 1883, 2003.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23

    Otterman NM, van Schie CH, van der Schaaf M, et al: An exercise programme for patients with diabetic complications: a study on feasibility and preliminary effectiveness. Diabet Med 28: 212, 2011.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24

    Simmons GH, Wong BJ, Holowatz LA, et al: Changes in the control of skin blood flow with exercise training: where do cutaneous vascular adaptations fit in? Exp Physiol 96: 822, 2011.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25

    Bentov I, Reed MJ: Anesthesia, microcirculation, and wound repair in aging. Anesthesiology 120: 760, 2014.

  • 26

    Boyko EJ, Ahroni JH, Stensel V, et al: A prospective study of risk factors for diabetic foot ulcer. The Seattle Diabetic Foot Study. Diabetes Care 22: 1036, 1999.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27

    Keylock KT, Vieira VJ, Wallig MA, et al: Exercise accelerates cutaneous wound healing and decreases wound inflammation in aged mice. Am J Physiol Regul Integr Comp Physiol 294: R179, 2008.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28

    Krisp C, Jacobsen F, McKay MJ, et al: Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients. Proteomics 13: 2670, 2013.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 29

    Leal EC, Carvalho E, Tellechea A, et al: Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype. Am J Pathol 185: 1638, 2015.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 30

    Petersen AM, Pedersen BK: The anti-inflammatory effect of exercise. J Appl Physiol (1985), 98: 1154, 2005.

  • 31

    Fischer CP, Hiscock NJ, Penkowa M, et al: Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. J Physiol 558: 633, 2004.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 32

    Alvarez OM, Rogers RS, Booker JG, et al: Effect of noncontact normothermic wound therapy on the healing of neuropathic (diabetic) foot ulcers: an interim analysis of 20 patients. J Foot Ankle Surg 42: 30, 2003.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 33

    McCulloch J, Knight CA: Noncontact normothermic wound therapy and offloading in the treatment of neuropathic foot ulcers in patients with diabetes. Ostomy Wound Manage 48: 38, 2002.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 34

    Leoni E, Legnani P, Guberti E, et al: Risk of infection associated with microbiological quality of public swimming pools in Bologna, Italy. Public Health 113: 227, 1999.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35

    Barna Z, Kadar M: The risk of contracting infectious diseases in public swimming pools. A review. Ann Ist Super Sanita 48: 374, 2012.

  • 36

    Klein EE, Crews RT, Wu SC, et al: CLEAR Cleat: a proof-of-concept trial of an aerobic activity facilitator to reduce plantar forefoot pressures and their potential in those with foot ulcers. JAPMA 98: 261, 2008.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37

    Peters EJ, Lavery LA: Effectiveness of the diabetic foot risk classification system of the International Working Group on the Diabetic Foot. Diabetes Care 24: 1442, 2001.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 38

    Lavery LA, Vela SA, Lavery DC, et al: Reducing dynamic foot pressures in high-risk diabetic subjects with foot ulcerations. A comparison of treatments. Diabetes Care 19: 818, 1996.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39

    Najafi B, Wrobel JS, Grewal G, et al: Plantar temperature response to walking in diabetes with and without acute charcot: the charcot activity response test. J Aging Res 2012: 140968, 2012.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 40

    Tanaka H, Monahan KD, Seals DR: Age-predicted maximal heart rate revisited. J Am Coll Cardiol 37: 153, 2001.

  • 41

    Gutekunst DJ, Hastings MK, Bohnert KL, et al: Removable cast walker boots yield greater forefoot off-loading than total contact casts. Clin Biomech (Bristol, Avon) 26: 649, 2011.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42

    Lavery LA, Armstrong DG: Temperature monitoring to assess, predict, and prevent diabetic foot complications. Curr Diab Rep 7: 416, 2007.

  • 43

    Sanders JE: Thermal response of skin to cyclic pressure and pressure with shear: a technical note. J Rehabil Res Dev 37: 511, 2000.

Preliminary Evaluation of a Cycling Cleat Designed for Diabetic Foot Ulcers

Ryan T. Crews Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Center for Lower Extremity Ambulatory Research (CLEAR), North Chicago, IL.

Search for other papers by Ryan T. Crews in
Current site
Google Scholar
PubMed
Close
 MS
,
Steven R. Smith HealthPartners Institute for Education and Research at Regions Hospital, St. Paul, MN.

Search for other papers by Steven R. Smith in
Current site
Google Scholar
PubMed
Close
 DPM
,
Ramin Ghazizadeh Vangard Weiss Memorial Hospital, Chicago, IL.

Search for other papers by Ramin Ghazizadeh in
Current site
Google Scholar
PubMed
Close
 DPM, MD
,
Sai V. Yalla Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Center for Lower Extremity Ambulatory Research (CLEAR), North Chicago, IL.

Search for other papers by Sai V. Yalla in
Current site
Google Scholar
PubMed
Close
 PhD
, and
Stephanie C. Wu Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Center for Lower Extremity Ambulatory Research (CLEAR), North Chicago, IL.
Department of Surgery, Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL.

Search for other papers by Stephanie C. Wu in
Current site
Google Scholar
PubMed
Close
 DPM, MS

Background:

Offloading devices for diabetic foot ulcers (DFU) generally restrict exercise. In addition to traditional health benefits, exercise could benefit DFU by increasing blood flow and acting as thermotherapy. This study functionally evaluated a cycling cleat designed for forefoot DFU.

Methods:

Fifteen individuals at risk of developing a DFU used a recumbent stationary bicycle to complete one 5-minute cycling bout with the DFU cleat on their study foot and one 5-minute bout without it. Foot stress was evaluated by plantar pressure insoles during cycling. Laser Doppler perfusion monitored blood flow to the hallux. Infrared photographs measured foot temperature before and after each cycling bout.

Results:

The specialized cleat significantly reduced forefoot plantar pressure (9.9 kPa versus 62.6 kPa, P < .05) and pressure time integral (15.4 versus 76.4 kPa*sec, P < .05). Irrespective of footwear condition, perfusion to the hallux increased (3.97 ± 1.2 versus 6.9 ± 1.4 tissue perfusion units, P < .05) after exercise. Infrared images revealed no changes in foot temperature.

Conclusions:

The specialized cleat allowed participants to exercise with minimal forefoot stress. The observed increase in perfusion suggests that healing might improve if patients with active DFU were to use the cleat. Potential thermotherapy for DFU was not supported by this study. Evaluation of the device among individuals with active DFU is now warranted.

Corresponding author: Ryan T. Crews, MS, Rosalind Franklin University of Medicine and Science, Dr. William M. Scholl College of Podiatric Medicine, Center for Lower Extremity Ambulatory Research (CLEAR), 3333 Green Bay Road, North Chicago, IL. (E-mail: ryan.crews@rosalindfranklin.edu)
Save