• 1

    Jaffe H, Lichtenstein L, Sutro C: Pigmented villonodular synovitis, bursitis and tenosynovitis. Arch Pathol 31: 731, 1941.

  • 2

    Dorwart RH, Genant HK, Johnston WH, et al: Pigmented villonodular synovitis of synovial joints: clinical, pathologic, and radiologic features. Am J Roentgenol 143: 877, 1984.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3

    Klompmaker J, Veth RP, Robinson PH, et al: Pigmented villonodular synovitis. Arch Orthop Trauma Surg 109: 205, 1990.

  • 4

    Myers BW, Masi AT, Feigenbaum SL: Pigmented villonodular synovitis and tenosynovitis: a clinical and epidemiologic study of 166 cases and literature review. Medicine 59: 223, 1980.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5

    Heller SL, O'Loughlin PF, Di Carlo G, et al: Pigmented villonodular synovitis about the ankle: two case reports. Foot Ankle Int 29: 527, 2008.

  • 6

    Duncan N, Rajan R: Case report of pigmented villonodular synovitis arising from the calcaneocuboid joint in a 12 year old male. Foot (Edinb) 25: 59, 2015.

  • 7

    Stevenson JD, Jaiswal A, Gregory JJ, et al: Diffuse pigmented villonodular synovitis (diffuse-type giant cell tumour) of the foot and ankle. Bone Joint J 95-B: 384, 2013.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 8

    Hao DP, Zhang JZ, Xu WJ, et al: Pigmented villonodular synovitis of the ankle: radiologic characteristics. JAPMA 101: 252, 2011.

  • 9

    Carpintero P, Gascon E, Mesa M, et al: Clinical and radiologic features of pigmented villonodular synovitis of the foot: report of eight cases. JAPMA 97: 415, 2007.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10

    Mavrogenis AF, Papaparaskeva KT, Galanakos S, et al: Pigmented villonodular synovitis of the distal tibiofibular joint: a case report. Clin Podiatr Med Surg 28: 589, 2011.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11

    Bisbinas I, De Silva U, Grimer RJ: Pigmented villonodular synovitis of the foot and ankle: a 12-year experience from a tertiary orthopedic oncology unit. J Foot Ankle Surg 43: 407, 2004.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Sakkers RJ, deJong D, van der Heul RO : X-chromosome inactivation in patients who have pigmented villonodular synonitis. J Bone Joint Surg Am 73: 1532, 1991.

  • 13

    Choong PF, Willen H, Nilbert M, et al: Pigmented villonodular synonitis: monoclonality and metastasis—a case for neoplastic origin? Acta Orthop Scand 66: 64, 1995.

  • 14

    Singh R, Grewal DS, Chakravarti RN: Experimental production of pigmented villonodular synovitis in the knee and ankle joints of rhesus monkeys. J Pathol 98: 137, 1969.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15

    Oehler S, Fassbender HG, Neureiter D, et al: Cell populations involved in pigmented villonodular synovitis of the knee. J Rheumatol 27: 463, 2000.

  • 16

    O'Keefe RJ, Rosier RN, Teot LA, et al: Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. Iowa Orthop J 18: 26, 1998.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17

    Uchibori M, Nishida Y, Tabata I, et al: Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in pigmented villonodular synovitis suggests their potential role for joint destruction. J Rheumatol 31: 110, 2004.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18

    Granowitz SP, D'Antonio J, Mankin HL: The pathogenesis and long-term end results of pigmented villonodular synovitis. Clin Orthop Relat Res 114: 335, 1976.

  • 19

    Villani C, Tucci G, Di Mille M, et al: Extra-articular localized nodular synovitis (giant cell tumor of tendon sheath origin) attached to the subtalar joint. Foot Ankle Int 17: 413, 1996.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20

    Kallas KM, Vaughan L, Haghighi P, et al: Pigmented villonodular synovitis of the hip presenting as a retroperitoneal mass. Skeletal Radiol 30: 469, 2001.

  • 21

    Kottal RA, Vogler JB III, Matamoros A, et al: Pigmented villonodular synovitis: a report of MR imaging in two cases. Radiology 163: 551, 1987.

  • 22

    Maldjian C, Rosenberg ZS : MR imaging features of tumors of the ankle and foot. Magn Reson Imaging Clin North Am 9: 639, 2001.

  • 23

    Korim MT, Clarke DR, Allen PE, et al: Clinical and oncological outcomes after surgical excision of pigmented villonodular synovitis at the foot and ankle. Foot Ankle Surg 20: 130, 2014.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24

    Schweitzer KM Jr, Parekh SG: Pigmented villonodular synovitis of the ankle: an anterior-posterior technique for excision. Foot Ankle Spec 6: 232, 2013.

  • 25

    Mohler DG, Kessler BD: Open synovectomy with cryosurgical adjuvant for treatment of diffuse pigmented villonodular synovitis of the knee. Bull Hosp Jt Dis 59: 99, 2000.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26

    Brien EW, Sacoman DM, Mirra JM: Pigmented villonodular synovitis of the foot and ankle. Foot Ankle Int 25: 908, 2004.

  • 27

    Lee M, Mahroof S, Pringle J, et al: Diffuse pigmented villonodular synovitis of the foot and ankle treated with surgery and radiotherapy. Int Orthop 29: 403, 2005.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation

Diffuse Pigmented Villonodular Synovitis Around the Ankle

Keiichi Muramatsu Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Ube, Japan.

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Ryuta Iwanaga Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Ube, Japan.

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Yasuhiro Tominaga Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Ube, Japan.

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Takahiro Hashimoto Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Ube, Japan.

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Toshihiko Taguchi Department of Orthopedic Surgery, Yamaguchi University School of Medicine, Ube, Japan.

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Background:

Pigmented villonodular synovitis (PVNS) is a rare disorder around the ankle joint. The optimal treatment for diffuse-type PVNS is still controversial because of the high incidence of recurrence. We present the clinical features of our patients and review the current diagnostic and treatment modalities.

Methods:

Five patients with PVNS located around the ankle were surgically treated. In three patients, diffuse PVNS arose from the ankle joint, and in the other two it arose from the calcaneocuboid and intercuneiform joints. The average follow-up time after surgery was 2.9 years (range, 2–4.6 years).

Results:

The average time between onset of pain and diagnosis of PVNS was 6.4 years (range, 4–10 years). Arthrotomic tumor resection was performed in all of the patients. In the three patients with ankle joint PVNS, both medial and lateral approaches were used. One patient experienced mild infection at the surgical site, but this healed conservatively. No tumor recurrences had occurred after minimum follow-up of 2 years, although mild pain persisted in the three patients with ankle PVNS.

Conclusions:

Diagnosis of diffuse PVNS is frequently delayed due to vague symptoms and variable growth patterns. Orthopedic clinicians should be aware of the existence of this lesion, and it should be suspected in patients with persistent ankle swelling. To prevent tumor recurrence, accurate evaluation of tumor location and careful operative planning are mandatory. A combined surgical approach involving medial and lateral incision is necessary to expose the entire joint cavity.

Corresponding author: Keiichi Muramatsu, MD, Department of Orthopedic Surgery, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. (E-mail: muramatu@yamaguchi-u.ac.jp)
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