• 1

    Boissy RE, Hearing VJ, King RA, et al: “Toxicological Aspects of Melanin and Melanogenesis,” in The Pigmentary System: Physiology and Pathophysiology , Vol 2, edited by J Nordlund, p 1025, Oxford University Press, New York, 1998.

    • Search Google Scholar
    • Export Citation
  • 2

    Sehgal VN, Srivastava G: Fixed drug eruption (FDE): changing scenario of incriminating drugs. Int J Dermatol 45: 897, 2006.

  • 3

    Shiohara T, Mizukawa Y, Teraki Y: Pathophysiology of fixed drug eruption: the role of skin-resident T Cells. Curr Opin Allergy Clin Immunol 8: 317, 2002.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 4

    Shiohara T: Fixed drug eruptions: pathogenesis and diagnostic tests. Curr Opin Allergy Clin Immunol 9: 316, 2009.

  • 5

    Mahboob A, Haroon TS: Drugs causing fixed eruptions: a study of 450 cases. Int J Dermatol 37: 833, 1998.

  • 6

    Ozkaya-Bayazit E: Specific site involvement in fixed drug eruptions. J Am Acad Dermatol 49: 1003, 2003.

  • 7

    Ozkaya-Bayazit E, Bayazit H, Ozarmagan G: Drug related clinical pattern in fixed drug eruption. Eur J Dermatol 10: 288, 2000.

  • 8

    Campi P, Pichler WJ: Quinolone hypersensitivity. Curr Opin Allergy Clin Immunol 3: 275, 2003.

  • 9

    Jain SP, Jain PA: Bullous fixed drug eruption to ciprofloxacin: a case report. J Clin Diagn Res 7: 744, 2013.

  • 10

    Neuhaus IM: “Cutaneous Signs and Diagnosis,” in Andrew's Diseases of the Skin: Clinical Dermatology , 11th Ed, edited by BD James, TG Berger, DM Elston, p 968, Elsevier, Philadelphia, 2005.

    • Search Google Scholar
    • Export Citation

Ciprofloxacin-Induced Bullae of the Lower Extremity: A Case of a Fixed Drug Reaction

Anthony J. Mollica Saint John Hospital and Medical Center, Detroit, MI.

Search for other papers by Anthony J. Mollica in
Current site
Google Scholar
PubMed
Close
 DPM
,
Albert J. Mollica Podiatry BC, Vancouver, British Columbia, Canada.

Search for other papers by Albert J. Mollica in
Current site
Google Scholar
PubMed
Close
 DPM
,
Elaine Grant Saint John Hospital and Medical Center, Detroit, MI.

Search for other papers by Elaine Grant in
Current site
Google Scholar
PubMed
Close
 DPM
,
Ali Malik Saint John Hospital and Medical Center, Detroit, MI.

Search for other papers by Ali Malik in
Current site
Google Scholar
PubMed
Close
 DPM
, and
Marc Claydon Saint John Hospital and Medical Center, Detroit, MI.

Search for other papers by Marc Claydon in
Current site
Google Scholar
PubMed
Close
 DPM
Restricted access

Cutaneous adverse drug reactions make up 1% to 2% of all adverse drug reactions. From these adverse cutaneous drug reactions, 16% to 21% can be categorized as fixed drug reactions (FDR). Fixed drug reactions may show diverse morphology including but not limited to the following: dermatitis, Stevens-Johnson syndrome, urticaria, morbilliform exanthema, hypersensitivity syndrome, pigmentary changes, acute generalized exanthematous pustulosis, photosensitivity, and vasculitis. An FDR will occur at the same site because of repeated exposure to the offending agent, causing a corresponding immune reaction. There are many drugs that can cause an FDR, such as analgesics, antibiotics, muscle relaxants, and anticonvulsants. The antibiotic ciprofloxacin has been shown to be a cause of cutaneous adverse drug reactions; however, the fixed drug reaction bullous variant is rare. This case study was published to demonstrate a rare adverse side effect to a commonly used antibiotic in podiatric medicine.

Corresponding author: Anthony J. Mollica, DPM, Saint John Hospital and Medical Center, 22201 Moross Rd, Ste 250, Detroit, MI 48236. (E-mail: anthonymollicatutor@gmail.com)