• 1.

    Campanacci M., Baldini N. & Boriani S. et al.: Giant-cell tumor of bone. J Bone Joint Surg Am 96: 106, 1987.

  • 2.

    Becker WT., Dohle J. & Bernd L. et al.: Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy. J Bone Joint Surg Am 90: 1060, 2008.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Picci P., Manfrini M. & Zucchi V. et al.: Giant-cell tumor of bone in skeletally immature patients. J Bone Joint Surg Am 65: 486, 1983.

  • 4.

    Buetow PC., Newman S. & Kransdorf MJ. Giant-cell tumor of the tibia in a child presenting as an expansile metaphyseal lesion with fluid-fluid levels on MR. Magn Reson Imaging 8: 341, 1990.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5.

    Kransdorf MJ., Sweet DE. & Buetow PC. et al.: Giant cell tumor in skeletally immature patients. Radiology 184: 233, 1992.

  • 6.

    Schütte HE. & Taconis WK. Giant cell tumor in children and adolescents. Skeletal Radiol 22: 173, 1993.

  • 7.

    Aaron AD., Kenan S. & Klein MJ. et al.: Case report 810: giant cell tumor of the first metatarsal. Skeletal Radiol 22: 543, 1993.

  • 8.

    Krajca-Radcliffe JB., Thomas JR. & Nicholas RW. Giant-cell tumor of bone: a rare entity in the hands of children. J Pediatr Orthop 14: 776, 1994.

  • 9.

    Nojima T., Takeda N. & Matsuno T. et al.: Case report 869: benign metastasizing giant cell tumor of bone. Skeletal Radiol 23: 583, 1994.

  • 10.

    Ashraf MS., Gururangan S. & Breatnach F. Benign giant cell tumor of bone in a child with pulmonary metastasis at presentation. Eur J Surg Oncol 20: 700, 1994.

    • Search Google Scholar
    • Export Citation
  • 11.

    Curilovic A., Eich GF. & Stallmach T. Giant cell tumor in the skull of a 9-year-old child: immunohistochemistry to confirm a diagnosis rare for age and site. Pediatr Pathol Lab Med 15: 769, 1995.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Morgan JD. & Eady JL. Giant cell tumor and the skeletally immature patient. J South Orthop Assoc 8: 275, 1999.

  • 13.

    Mondal A., Kundu B. & Kundu R. et al.: Multifocal giant cell tumour of bone in a skeletally immature patient: a case report. Indian J Pathol Microbiol 44: 479, 2001.

    • Search Google Scholar
    • Export Citation
  • 14.

    Cottalorda J., Bourelle S. & Stéphan JL. et al.: Radiologic case study. Giant-cell tumor of the wrist in a skeletally immature girl. Orthopedics 25: 470, 2002.

    • Search Google Scholar
    • Export Citation
  • 15.

    Taylor KF., Yingsakmongkol W. & Conard KA. et al.: Multicentric giant cell tumor of bone: a case report and review of literature. Clin Orthop Relat Res 410: 267, 2003.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 16.

    Stratil PG. & Stacy GS. Multifocal metachronous giant cell tumor in a 15-year-old boy. Pediatr Radiol 35: 444, 2005

  • 17.

    Ramdas A., Rao KR. & Thomas A. et al.: Giant cell tumor of talus: a case report. J Indian Med Assoc 105: 96, 2007.

  • 18.

    Puri A., Agarwal MG. & Shah M. et al.: Giant cell tumor of bone in children and adolescents. J Pediatr Orthop 27: 635, 2007.

  • 19.

    Chang CC., Chang ST. & Chang HY. et al.: Multicentric giant cell tumours in an adolescent with haemophilia. Haemophilia 13: 199, 2007.

  • 20.

    Elder JB., Berry C. & Gonzalez-Gomez I. et al.: Giant cell tumor of the skull in pediatric patients. Report of two cases. J Neurosurg 107 (suppl) : 69, 2007.

  • 21.

    Gandhe A., Sankhe A. & Aeron G. et al.: Epiphyseal giant cell tumour in an immature skeleton. Br J Radiol 81: e75, 2008.

  • 22.

    Nag S., Jain VK. & Singh Y. et al.: Giant cell tumour of bone in a skeletally immature patient. ANZ J Surg 79: 763, 2009.

  • 23.

    Harsha A., Villalobos CE. & Rybak LD. et al.: Orthopaedic, radiology, pathology conference: painful distal femur lesion in a 13-year-old girl. Clin Orthop Relat Res 467: 2200, 2009.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 24.

    Baker JF., Perera A. & Kiely PD. et al.: Giant cell tumour in the foot of a skeletally immature girl: a case report. J Orthop Surg (Hong Kong). 17: 248, 2009.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 25.

    Varshney A., Rao H. & Sadh R. Multicentric GCT of tarsal bones in an immature skeleton: a case report with review of literature. J Foot Ankle Surg 49: 399, 2010.

    • Search Google Scholar
    • Export Citation
  • 26.

    Dridi M., Ben SS. & M'Barek M. et al.: Metatarsal giant cell tumour in a 7-year-old child: a case report. Acta Orthop Belg 77: 843, 2011.

  • 27.

    Murphey MD., Nomikos GC. & Flemming DJ. et al.: Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics 21: 1283, 2001.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Siddiqui YS., Zahid M. & Bin Sabir A. et al.: Giant cell tumour of the first metatarsal. J Cancer Res Ther 7: 208, 2011.

  • 29.

    Turcotte RE. Giant cell tumor of bone. Orthop Clin North Am 37: 35, 2006.

  • 30.

    Balaji GG., Roy AC. & Justin SV. Techniques in recurrent giant cell tumor of the first metatarsal in adolescents: a rare report of 2 cases. Foot Ankle Surg 19: e1, 2013.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31.

    James SL. & Davies AM. Giant-cell tumours of bone of the hand and wrist: a review of imaging findings and differential diagnoses. Eur Radiol. 15: 1855, 2005.

  • 32.

    Jaffe HL., Lichtenstein L. & Portis RB. Giant cell tumour of bone. Its pathologic appearance, grading, supposed variants and treatment. Arch Pathol 30: 993, 1940.

    • Search Google Scholar
    • Export Citation
  • 33.

    Dahlin DC., Cupps RE. & Johnson EW. Jr: Giant cell tumour: a study of 195 cases. Cancer 25: 1061, 1970.

  • 34.

    Larsson R., Lorentzon L. & Boquist L. Giant cell tumour of bone: A demographic, clinical, and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958 through 1968. J Bone Joint Surg Am 57: 167, 1975.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 35.

    Sung HW., Kuo DP. & Shu WP. et al.: Giant cell tumor of bone: analysis of two hundred and eight cases in Chinese patients. J Bone Joint Surg Am 64: 755, 1982.

Can Giant Cell Tumor of the Bone Occur in the Skeletally Immature?

Amber Haseeb MS Orth (UM)1, Vivek Ajit Singh MS Orth (UM), FRCS (Ed), CMIA, AM (Mal)1, and Pailoor Jayalakshmi  MPath (UM), FRCPath (UK)2
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  • 1 Department of Orthopaedic Surgery, National Orthopaedic Center of Excellence for Research and Learning, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • | 2 Department of Medical Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
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Giant cell tumor (GCT) of the bone is a benign, locally aggressive neoplasm that has a high tendency for local recurrence. It usually has a higher incidence in the third decade of life. This is a retrospective review of a case with histologic confirmation of GCT in a skeletally immature patient involving the metatarsal bone, which is a rare site. At our institution, 1.3% of skeletally immature patients had GCT of the bone. From an extensive literature review, only four cases of GCT of the metatarsal bone in the skeletally immature were identified. Giant cell tumor in a skeletally immature patient can be confused for an aneurysmal bone cyst because of similar radiologic findings. Giant cell tumor of the bone can occur in an immature skeleton and should be sought out as a differential diagnosis despite being rare.

Corresponding author: Amber Haseeb, MS Orth (UM), Department of Orthopaedic Surgery, National Orthopaedic Center of Excellence for Research and Learning, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. (E-mail: dramber84@gmail.com)