Willard KJ , Cappel MA & Kozin SH et al.: Benign subungual tumors. J Hand Surg Am 37 : 1276, 2012.
Baek HJ , Lee SJ & Cho KH et al.: Subungual tumors: clinicopathologic correlation with US and MR imaging findings. Radiographics 30 : 1621, 2010.
DaCambra MP , Gupta SKl & Ferri-de-Barros F: Subungual exostosis of the toes: a systematic review. Clin Orthop Relat Res 472 : 1251, 2014.
Nikenejad H , Khayat-Khoei M & Peirovi H et al.: Human amniotic epithelial cells induce apoptosis of cancer cells: a new anti-tumor therapeutic strategy. Cytotherapy 16 : 33, 2014.
Kim EC , Kim MS & Kang NY: Excision with corneoscleral lamellar keratoplasty and amniotic membrane transplantation of a corneal displaced recurrent conjunctival melanoma. Korean J Opthalmol 26 : 383, 2012.
Cooke M , Tan EK & Mandrycky C et al.: Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane/chorion tissue. J Wound Care 23 : 465, 2014.
Kang NH , Yi BR & Lim SY et al.: Human amniotic membrane-derived epithelial stem cells display anticancer activity in BALB/c female nude mice bearing disseminated breast cancer xenografts. Int J Oncol 40 : 2022, 2012.
Jackson WM , Nesti LJ & Tuan RS: Mesenchymal stem cell therapy for attenuation of scar formation during wound healing. Stem Cell Res Ther 3 : 20, 2012.
DiDomenico LA , Orgill DP & Galiano RD et al.: Aseptically processed placental membrane improves healing of diabetic foot ulcerations: prospective, randomized clinical trial. Plast Reconstr Surg Glob Open 4 : e1095, 2016.
Chen W , Liu J & Manuchehrabadi N et al.: Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects. Biomaterials 34 : 9917, 2013.
Brantley J & Verla T: Use of placental membranes for the treatment of chronic diabetic foot ulcers. Adv Wound Care 4 : 545, 2015.
Davis DA & Cohen PR: Subungual exostosis: case report and review of the literature. Pediatr Dermatol 13 : 212, 1996.
Meller D , Pauklin M & Thomasen H et al.: Amniotic membrane transplantation in the human eye. Dtsch Arztebl Int 108 : 243, 2011.
Rossi D , Pianta S & Magatti M et al.: Characterization of the conditioned medium from amniotic membrane cells: prostaglandins as key effectors of its immunomodulatory activity. PLoS One 7: e46956, 2012. [Q1]
Jia L , Gu W & Zhang Y et al.: The crosstalk between HDPSCs and HUCMSCs on proliferation and osteogenic genes expression in coculture system. Int J Med Sci 14 : 1118, 2017.
Lee K , Chan CK & Patil N et al.: Cell therapy for bone regeneration: bench to bedside. J Biomed Mater Res B Appl Biomater 89 : 252, 2009.
Nail pathologies have a broad range of origin and may sometimes be complicated in presentation or clinical course, specifically when the pathology remains recalcitrant after treatment. In this case report we discuss a pathologic disorder that was initially misdiagnosed as a pyogenic granuloma surrounding an ingrown nail but was later found to be a benign neoplastic bone growth, Dupuytren exostosis, also known as a subungual exostosis. Operative treatment was deemed appropriate for the patient, and the exostosis was resected, leaving a soft-tissue void at the distal toe. The remaining void was filled with a perinatal graft, the use of which has been deemed effective anecdotally in both chronic and acute lower-extremity wounds but has not been widely discussed in the lower-extremity literature. This graft was placed to aid in wound healing over a potentially difficult wound bed. As amniotic, chorionic, and umbilical grafts become more prevalent in lower-extremity surgery, its antitumor effects should be further explored and published. This is the first case report, to our knowledge, of the successful use of a perinatal graft in the setting of a bone tumor, and it demonstrates that certain benign neoplasms can be treated with resection and placement of a perinatal graft while helping to prevent chronic wounds at surgical sites.
Department of Surgery, South Nassau Communities Hospital, Oceanside, NY.
Department of Pathology, South Nassau Communities Hospital, Oceanside, NY.