• 1. 

    Willard KJ , Cappel MA & Kozin SH et al.: Benign subungual tumors. J Hand Surg Am 37 : 1276, 2012.

  • 2. 

    Baek HJ , Lee SJ & Cho KH et al.: Subungual tumors: clinicopathologic correlation with US and MR imaging findings. Radiographics 30 : 1621, 2010.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 3. 

    DaCambra MP , Gupta SKl & Ferri-de-Barros F: Subungual exostosis of the toes: a systematic review. Clin Orthop Relat Res 472 : 1251, 2014.

  • 4. 

    Nikenejad H , Khayat-Khoei M & Peirovi H et al.: Human amniotic epithelial cells induce apoptosis of cancer cells: a new anti-tumor therapeutic strategy. Cytotherapy 16 : 33, 2014.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 5. 

    Kim EC , Kim MS & Kang NY: Excision with corneoscleral lamellar keratoplasty and amniotic membrane transplantation of a corneal displaced recurrent conjunctival melanoma. Korean J Opthalmol 26 : 383, 2012.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6. 

    Cooke M , Tan EK & Mandrycky C et al.: Comparison of cryopreserved amniotic membrane and umbilical cord tissue with dehydrated amniotic membrane/chorion tissue. J Wound Care 23 : 465, 2014.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 7. 

    Kang NH , Yi BR & Lim SY et al.: Human amniotic membrane-derived epithelial stem cells display anticancer activity in BALB/c female nude mice bearing disseminated breast cancer xenografts. Int J Oncol 40 : 2022, 2012.

    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 8. 

    Jackson WM , Nesti LJ & Tuan RS: Mesenchymal stem cell therapy for attenuation of scar formation during wound healing. Stem Cell Res Ther 3 : 20, 2012.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 9. 

    DiDomenico LA , Orgill DP & Galiano RD et al.: Aseptically processed placental membrane improves healing of diabetic foot ulcerations: prospective, randomized clinical trial. Plast Reconstr Surg Glob Open 4 : e1095, 2016.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10. 

    Chen W , Liu J & Manuchehrabadi N et al.: Umbilical cord and bone marrow mesenchymal stem cell seeding on macroporous calcium phosphate for bone regeneration in rat cranial defects. Biomaterials 34 : 9917, 2013.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 11. 

    Brantley J & Verla T: Use of placental membranes for the treatment of chronic diabetic foot ulcers. Adv Wound Care 4 : 545, 2015.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 12. 

    Davis DA & Cohen PR: Subungual exostosis: case report and review of the literature. Pediatr Dermatol 13 : 212, 1996.

  • 13. 

    Meller D , Pauklin M & Thomasen H et al.: Amniotic membrane transplantation in the human eye. Dtsch Arztebl Int 108 : 243, 2011.

    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 14. 

    Rossi D , Pianta S & Magatti M et al.: Characterization of the conditioned medium from amniotic membrane cells: prostaglandins as key effectors of its immunomodulatory activity. PLoS One 7: e46956, 2012. [Q1]

    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 15. 

    Jia L , Gu W & Zhang Y et al.: The crosstalk between HDPSCs and HUCMSCs on proliferation and osteogenic genes expression in coculture system. Int J Med Sci 14 : 1118, 2017.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 16. 

    Lee K , Chan CK & Patil N et al.: Cell therapy for bone regeneration: bench to bedside. J Biomed Mater Res B Appl Biomater 89 : 252, 2009.

A Novel Use of Umbilical Perinatal Graft in Subungual Exostosis Resection

Juan Carlos Goez
Search for other papers by Juan Carlos Goez in
Current site
Google Scholar
PubMed
Close
 DPM
,
Roger Lee Kilfoil Jr
Search for other papers by Roger Lee Kilfoil Jr in
Current site
Google Scholar
PubMed
Close
 DPM
,
Chen-An Wang
Search for other papers by Chen-An Wang in
Current site
Google Scholar
PubMed
Close
 DPM
,
Zachary Sax
Search for other papers by Zachary Sax in
Current site
Google Scholar
PubMed
Close
 DPM
, and
Farzana Arif
Search for other papers by Farzana Arif in
Current site
Google Scholar
PubMed
Close
 MD

Nail pathologies have a broad range of origin and may sometimes be complicated in presentation or clinical course, specifically when the pathology remains recalcitrant after treatment. In this case report we discuss a pathologic disorder that was initially misdiagnosed as a pyogenic granuloma surrounding an ingrown nail but was later found to be a benign neoplastic bone growth, Dupuytren exostosis, also known as a subungual exostosis. Operative treatment was deemed appropriate for the patient, and the exostosis was resected, leaving a soft-tissue void at the distal toe. The remaining void was filled with a perinatal graft, the use of which has been deemed effective anecdotally in both chronic and acute lower-extremity wounds but has not been widely discussed in the lower-extremity literature. This graft was placed to aid in wound healing over a potentially difficult wound bed. As amniotic, chorionic, and umbilical grafts become more prevalent in lower-extremity surgery, its antitumor effects should be further explored and published. This is the first case report, to our knowledge, of the successful use of a perinatal graft in the setting of a bone tumor, and it demonstrates that certain benign neoplasms can be treated with resection and placement of a perinatal graft while helping to prevent chronic wounds at surgical sites.

Department of Surgery, South Nassau Communities Hospital, Oceanside, NY.

Department of Pathology, South Nassau Communities Hospital, Oceanside, NY.

Corresponding author: Roger Lee Kilfoil, Jr, DPM, Department of Surgery, South Nassau Communities Hospital, 830A Atlantic Ave, Baldwin, NY, 11755. (E-mail: Rogerkilfoiljr@gmail.com)
Save