• 1. 

    Karia PS , Han J & Schmults CD: Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol 68 : 957, 2013.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 2. 

    Brantsch KD , Meisner C & Schönfisch B et al.: Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol 9 : 713, 2008.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3. 

    Samarasinghe V , Madan V & Lear JT: Management of high-risk squamous cell carcinoma of the skin. Expert Rev Anticancer Ther 11 : 763, 2011.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 4. 

    Farasat S , Yu SS & Neel VA et al.: A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics. J Am Acad Dermatol 64 : 1051, 2011.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 5. 

    Rowe DE , Carroll RJ & Day CL Jr: Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip: implications for treatment modality selection. J Am Acad Dermatol 26 : 976, 1992.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6. 

    Brougham ND , Dennett ER & Cameron R et al.: The incidence of metastasis from cutaneous squamous cell carcinoma and the impact of its risk factors. J Surg Oncol 106 : 811, 2012.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 7. 

    Yanofsky VR , Mercer SE & Phelps RG: Histopathological variants of cutaneous squamous cell carcinoma: a review. J Skin Cancer 2011 : 210813, 2011.

  • 8. 

    Cherpelis BS , Marcusen C & Lang PG: Prognostic factors for metastasis in squamous cell carcinoma of the skin. Dermatol Surg 28 : 268, 2002.

  • 9. 

    Ames FC & Hickey RC: Squamous cell carcinoma of the skin of the extremities. Int Adv Surg Oncol 3 : 179, 1980.

  • 10. 

    Johnson TM , Rowe DE & Nelson BR et al.: Squamous cell carcinoma of the skin (excluding lip and oral mucosa). J Am Acad Dermatol 26 : 467, 1992.

  • 11. 

    Barksdale SK , O'Connor N & Barnhill R: Prognostic factors for cutaneous squamous cell and basal cell carcinoma: determinants of risk of recurrence, metastasis, and development of subsequent skin cancers. Surg Oncol Clin N Am 6 : 625, 1997.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12. 

    North JH Jr, , Spellman JE & Driscoll D et al.: Advanced cutaneous squamous cell carcinoma of the trunk and extremity: analysis of prognostic factors. J Surg Oncol 64 : 212, 1997.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13. 

    Mullen JT , Feng L & Xing Y et al.: Invasive squamous cell carcinoma of the skin: defining a high-risk group. Ann Surg Oncol 13 : 902, 2006.

  • 14. 

    Edwards MJ , Hirsch RM & Broadwater JR et al.: Squamous cell carcinoma arising in previously burned or irradiated skin. Arch Surg 124 : 115, 1989.

  • 15. 

    Lansbury L , Bath-Hextall F & Perkins W et al.: Interventions for non-metastatic squamous cell carcinoma of the skin: systematic review and pooled analysis of observational studies. BMJ 347 : f6153, 2013.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 16. 

    Bath-Hextall FJ , Matin RN & Wilkinson D et al.: Interventions for cutaneous Bowen's disease. Cochrane Database Syst Rev 2013 : CD007281, 2013.

    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 17. 

    Lansbury L , Leonardi-Bee J & Perkins W et al.: Interventions for non-metastatic squamous cell carcinoma of the skin. Cochrane Database Syst Rev 4 : CD007869, 2010.

    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 18. 

    Holgado RD , Ward SC & Suryaprasad SG: Squamous cell carcinoma of the hallux. JAPMA 90 : 309, 2000.

  • 19. 

    Pavlovic S , Surowiec D & Braniecki M: Marjolin's ulcer of the hallux. JAPMA 103 : 250, 2013.

Primary Invasive Squamous Cell Carcinoma of the Foot

A Case Report

Jordan Henning
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Zachary Rasor
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Andrew Brown
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Anthony Blanchard
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Bryan Hall
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Malignant transformation of wounds is a rare complication that if missed can lead to loss of life or limb. This case report presents a rare invasive variant of squamous cell carcinoma presenting in the setting of a chronic wound complicated by osteomyelitis. This aggressive form of squamous cell carcinoma has a high growth rate and a high propensity for metastasis and recurrence. Early intervention greatly decreases the risk of metastasis and recurrence. We present the systematic evaluation and surgical management of an aggressive primary tumor occurring in the forefoot.

Department of Podiatry, University of Cincinnati Medical Center, Cincinnati, OH.

Corresponding author: Jordan Henning, DPM, Department of Podiatry, University of Cincinnati Medical Center, 231 Albert Sabin Way, ML 0513, Cincinnati, OH 45267. (E-mail: jhenningdpm@gmail.com)
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