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1.
Centers for Disease Control and Prevention: National Diabetes Statistics Report, 2017: Estimates of Diabetes and Its Burden in the United States, Centers for Disease Control and Prevention, Atlanta, 2017.
-
2.
Mavrogenis AF , Antoniadou T & Dimopoulos L et al.: Current concepts for the evaluation and management of diabetic foot ulcers. Foot Ankle 3 : 513, 2018.
-
3.
Apelqvist J: Diagnostics and treatment of the diabetic foot. Endocrine 41 : 384, 2012.
-
4.
Jneid J , Cassir N & Schuldiner S et al.: Exploring the microbiota of diabetic foot infections with culturomics. Front Cell Infect Microbiol 8 : 1, 2018.
-
5.
Lipsky BA , Berendt AR & Deery HG et al.: Diagnosis and treatment of diabetic foot infections. Plast Reconstr Surg 117 : 212, 2006.
-
6.
Brem H , Sheehan P & Rosenberg HJ et al.: Evidence-based protocol for diabetic foot ulcers. Plast Reconstr Surg 117 : 193S, 2006.
-
7.
Rice JB , Desai U & Cummings AKG et al.: Burden of diabetic foot ulcers for Medicare and private insurers. Diabetes 37 : 651, 2014.
-
8.
Nelson EA , Meara SO & Craig D et al.: A series of systematic reviews to inform a decision analysis for sampling and treating infected diabetic foot ulcers. Health Technol Assess 10 : 1, 2006.
-
9.
Hingorani A , Lamuraglia GM & Henke P et al.: The management of diabetic foot: a clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine. J Vasc Surg 63 : 3S, 2016.
-
10.
Zelen CM , Serena TE & Gould L et al.: Treatment of chronic diabetic lower extremity ulcers with advanced therapies: a prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost. Int Wound J 13 : 272, 2015.
-
11.
Dinh TL & Veves A: The efficacy of Apligraf in the treatment of diabetic foot ulcers. Plast Reconstr Surg 117 : 152S, 2006.
-
12.
Hankin CS , Knispel J & Lopes M et al.: Clinical and cost efficacy of advanced wound care matrices for venous ulcers. J Manag Care Pharm 18 : 375, 2012.
-
13.
Redekop WK , McDonnell J & Verboom P et al.: The cost effectiveness of Apligraf ® treatment of diabetic foot ulcers. Pharmacoeconomics 21 : 1171, 2003.
-
14.
Schonfeld WH , Villa KF & Fastenau JM et al.: An economic assessment of Apligraf (Graftskin) for the treatment of hard-to-heal venous leg ulcers. Wound Repair Regen 8 : 251, 2000.
-
15.
Lipsky BA & Berendt AR: Hyperbaric oxygen therapy for diabetic foot wounds. Diabetes Care 33 : 1143, 2010.
-
16.
Gray M & Ratliff CR: Is hyperbaric oxygen therapy effective for the management of chronic wounds? J Wound Ostomy Continence Nurs 33 : 21, 2006.
-
17.
Chuck AW , Hailey D & Jacobs P et al.: Cost-effectiveness and budget impact of adjunctive hyperbaric oxygen therapy for diabetic foot ulcers. Int J Technol Assess Health Care 2 : 178, 2018.
-
18.
Alexander L , Andreas S & Grabbe S et al.: Influence of pH on wound-healing: a new perspective for wound-therapy? Arch Dermatol Res 298 : 413, 2007.
-
19.
Gethin G: The significance of surface pH in chronic wounds. Wounds UK 3 : 52, 2007.
-
20.
Rushton I: Understanding the role of proteases and pH in wound healing. Nurs Stand 21 : 68, 2007.
-
21.
McArdle C , Lagan KM & Mcdowell DA: The pH of wound fluid in diabetic foot ulcers: the way forward in detecting clinical infection? Curr Diabetes Rev 10 : 177, 2014.
-
22.
Löffler MW , Schuster H & Biochem D et al.: Wound fluid in diabetic foot ulceration: more than just an undefined soup? Int J Low Extrem Wounds 12: 113, 2013. [Q6]
-
23.
Shukla VK , Sjukla D & Twary SK et al.: Evaluation of pH measurement as a method of wound assessment. J Wound Care 7 : 291, 2007.
-
24.
Leveen HH , Falk G & Borek B et al.: Chemical acidification of wounds: an adjuvant to healing and the unfavorable action of alkalinity and ammonia. Ann Surg 6 : 745, 1973.
-
25.
Lonnqvist S , Emanuelsson P & Kratz G: Influence of acidic pH on keratinocyte function and re-epithelialilisation of human in vitro wounds. J Plast Surg Hand Surg 6 : 346, 2015.
-
26.
Martinez-De Jesus FR , Ramos-De la Medina A , Remes-Troche JM : Efficacy and safety of neutral pH superoxidised solution in severe diabetic foot infections. Int Wound J 4 : 353, 2007.
-
27.
Sharpe JR , Harris KL & Jubin K et al.: The effect of pH in modulating skin cell behaviour. Br J Dermatol 3 : 671, 2009.
-
28.
Gethin GT , Cowman S & Conroy RM: The impact of Manuka honey dressings on the surface pH of chronic wounds. Int Wound J 2 : 185, 2008.
-
29.
Thomas J , Linton S & Corum L et al.: The affect of pH and bacterial phenotypic state on antibiotic efficacy. Int Wound J 4 : 428, 2011.
The Effect of Wound pH on Healing Rates in Chronic Wounds: A Literature Review
This literature review sought to evaluate the current state of knowledge and guidelines surrounding the role of pH in the recovery of chronic nonhealing wounds. A systematic review of PubMed examining the relationship between pH and wound healing was completed. Seven sources were retrieved for review. The development of a highly structured and reproducible system of pH-driven therapy may add to the treatment algorithm for chronic nonhealing wounds.
New York College of Podiatric Medicine, New York, NY.
