• 1. 

    Franke U, Homes L & Atkins L et al.: Aniridia-Wilms tumor associations: evidence for specific deletion of 11p13. Cytogenet Cell Genet 24 : 185, 1979.

  • 2. 

    Fischbach B, Trout K & Lewis J et al.: WAGR syndrome: a clinical review of 54 cases. Pediatrics 116 : 984, 2005.

  • 3. 

    Rose E, Glaser T & Jones C: Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene. Cell 60 : 495, 1990.

  • 4. 

    Glaser T, Jepeal L & Edwards J et al.: PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Nat Genet 7 : 463, 1994.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 5. 

    Talamillo A, Quinn J & Collinson J: PAX6 regulates regional development and neuronal migration in the cerebral cortex. Dev Biol 255 : 151, 2003.

  • 6. 

    Chao L, Huff V & Strong L et al.: Mutation in the PAX6 gene in twenty patients with aniridia. Hum Mutat 15 : 332, 2000.

  • 7. 

    Miller R, Farumeni J Jr, & Manning M: Association of Wilms' tumor with aniridia, hemihypertrophy and other congenital malformations. N Engl J Med 270 : 922, 1964.

  • 8. 

    Breslow N, Norris R & Norkool P: Characteristics and outcomes of children with the Wilms' tumor-aniridia syndrome: a report from the National Wilms' Tumor Study Group. J Clin Oncol 24 : 4579, 2003.

    • Search Google Scholar
    • Export Citation
  • 9. 

    Ivanov I, Shuper A & Shohad M et al.: Aniridia: recent achievements in clinical practice. Eur J Pediatr 154 : 795, 1995.

  • 10. 

    Huang WC, Levey AS & Serio AM et al.: Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol 7 : 735, 2006.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11. 

    Hörl WH: Nonsteroidal anti-inflammatory drugs and the kidney. Pharmaceuticals 3 : 2291, 2010.

Pediatric Delayed Union in the Presence of WAGR Syndrome

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In this study, we present the management of an intra-articular fracture in a 13-year-old boy with WAGR syndrome, an extremely rare genetic disorder. The goal of this study was to provide possible solutions to the complex pain management requirements presenting in the setting of trauma to the right lower extremity. Given the scarcity of literature available with regard to this condition, we aim to not only increase awareness of the disease but also provide insight into trauma management and expected outcomes.

Quantum Foot and Ankle Group, PC, Woodcliff Lake, NJ.

Corresponding author: J. Adrian Wright, MS, DPM, AACFAS, Quantum Foot and Ankle Group, 577 Chestnut Ridge Rd, Ste 9, Woodcliff Lake, NJ 07677. (E-mail: jwright@quantumfootandanklegroup.com)