• 1. 

    Gibbons CL, Khwaja HA & Cole AS et al.: Giant-cell tumour of the tendon sheath in the foot and ankle. J Bone Joint Surg Br 84 : 1000, 2002.

  • 2. 

    Zhang Y, Huang J & Ma X et al.: Giant cell tumor of the tendon sheath in the foot and ankle: case series and review of the literature. J Foot Ankle Surg 52 : 24, 2013.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 3. 

    Monaghan H, Salter DM & Al-Nafussi A: Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases. J Clin Pathol 54 : 404, 2001.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4. 

    Fraser EJ, Sullivan M & Maclean F et al.: Tenosynovial giant-cell tumors of the foot and ankle: a critical analysis review. J Bone Joint Surg Rev 5 : 1, 2017.

    • Search Google Scholar
    • Export Citation
  • 5. 

    Somerhausen NS & van den Rijn M: “Tenosynovial Giant Cell Tumor, Diffuse Type,” in World Health Organization Classification of Tumours of Soft Tissue and Bone, 4th ed, edited by Fletcher CDM, Bridge JA, Hogendoorn PCW & Mertens F p 102, IARC Press, Lyon, France, 2013.

    • Search Google Scholar
    • Export Citation
  • 6. 

    Righi A, Gambarotti M & Sbaraglia M et al.: Metastasizing tenosynovial giant cell tumour, diffuse type/pigmented villonodular synovitis. Clin Sarcoma Res 5 : 15, 2015.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 7. 

    Marcheix PS, Roger T & Coindre JM et al.: Lung metastases of diffuse giant cell tumour of the fibular tendon sheath at the ankle: a case report. Orthop Traumatol Surg Res 103 : 399, 2017.

    • Crossref
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 8. 

    Korim MT, Clarke DR & Allen PE et al.: Clinical and oncological outcomes after surgical excision of pigmented villonodular synovitis at the foot and ankle. Foot Ankle Surg 20 : 130, 2014.

    • Crossref
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 9. 

    Çevik HB, Kayahan S & Eceviz E: Tenosynovial giant cell tumor in the foot and ankle. Foot Ankle Surg 26 : 712, 2020.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 10. 

    Palmerine E, Staals EL & Maki RG et al.: Tenosynovial giant cell tumour/pigmented villonodular synovitis: outcome of 294 patients before the era of kinase inhibitors. Eur J Cancer 51 : 210, 2015.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 11. 

    Wan J, Magarelly N & Peh V et al.: Imaging of giant cell tumour of the tendon sheath. Radiol Med 115 : 141, 2010.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 12. 

    De Scheper AM, Hogendoorn PC & Bloem JL: Giant cell tumors of the tendon sheath may present radiologically as intrinsic osseous lesions. Eur Radiol 17 : 499, 2007.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 13. 

    Wang C, Song RR & Kuang PD et al.: Giant cell tumor of the tendon sheath: magnetic resonance imaging findings in 38 patients. Oncol Lett 13 : 4459, 2017.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 14. 

    Levi M & Crafton J: Rare giant cell of the distal flexor digitorum longus tendon sheath and early diagnosis with use of magnetic resonance imaging. JAPMA 107 : 333, 2017.

    • Search Google Scholar
    • Export Citation
  • 15. 

    Middleton WD, Patel V & Teefey SA et al.: Giant cell tumors of the tendon sheath: analysis of sonographic findings. AJR Am J Roentgenol 183 : 337, 2004.

  • 16. 

    Vargaonkar G, Singh V & Arora S et al.: Giant cell tumor of the tendon sheath around the foot and ankle. A report of three cases and a literature review. JAPMA 105 : 249, 2015.

    • Search Google Scholar
    • Export Citation
  • 17. 

    Gouin F & Noailles T: Localized and diffuse forms of tenosynovial giant cell tumor (formerly giant cell tumor of the tendon sheath and pigmented villonodular synovitis). Orthop Traumatol Surg Res 103 : S91, 2017.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation

Tenosynovial Giant Cell Tumor in the Forefoot: Two Case Reports and Literature Review

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Tenosynovial giant cell tumor is the common term used to describe a group of soft-tissue tumors that share a common etiologic link. These tumors are relatively infrequent in the foot and ankle, and occasionally they may be the cause of destruction of the adjacent bone structures. We report the imaging appearance and pathologic findings of two patients with localized tenosynovial giant cell tumor of the forefoot. Both of these patients underwent surgical gross total resection. However, one of the patients experienced a recurrence. Their clinical, radiologic, and pathologic features, with their treatment protocol, are summarized retrospectively, and related literature is reviewed in an attempt to enhance the understanding of these tumor lesions. Clinicians should perform a careful preoperative and postoperative examination and complete tumor surgical resection with the aim of reducing local recurrence.

Departamento de Podología, Universidad de Sevilla, Sevilla, Spain.

Orlando Foot and Ankle Clinic, Orlando, FL.

Corresponding author: Antonio Córdoba-Fernández, DPM, PhD, Universidad de Sevilla, Avicena Street s/n Seville, Seville 41009, Spain. (E-mail: acordoba@us.es)