advertising
-
1.
Boulton AJ , Vileikyte L & Ragnarson-Tennvall G et al.: The global burden of diabetic foot disease. Lancet 366 : 1719, 2005.
-
2.
Gupta S: Management of diabetic foot. Medicine Update 22 : 287, 2012.
-
3.
Snyder RJ & Hanft JR: Diabetic foot ulcers: effects on QOL, costs, and mortality and the role of standard wound care and advanced-care therapies. Ostomy Wound Manage 55 : 28, 2009.
-
4.
Brem H , Sheehan P & Rosenberg HJ et al.: Evidence-based protocol for diabetic foot ulcers. Plast Reconstr Surg 117 : 193S, 2006.
-
5.
Grek CL , Prasad GM & Viswanathan V et al.: Topical administration of a connexin 43-based peptide augments healing of chronic neuropathic diabetic foot ulcers: a multicenter, randomized trial. Wound Repair Regen 23 : 203, 2015.
-
6.
Tzeng YS , Deng SC & Wang CH et al.: Treatment of non-healing diabetic lower extremity ulcers with skin graft and autologous platelet gel: a case series. Biomed Res Int 2013 : 837620, 2013.
-
7.
Kargar S , Javadzadeh Shahshahani H & Tabkhi N et al.: The effect of platelet gel on the treatment of diabetic foot ulcer. Sci J Iran Blood Transfus Org 6 : 283, 2010.
-
8.
Driver VR , Hanft J & Fylling CP et al.: A prospective, randomised, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy Ulcer Manage 52 : 68, 2006.
-
9.
Tran TD-X , Le PT-B & Pham PV: Diabetic foot ulcer treatment by activated platelet rich plasma: a clinical study. Biomed Res Ther 1 : 37, 2014.
-
10.
Salem A & Tawfik AM: Role of platelet rich plasma in treatment of diabetic foot ulcers. Surg Sci 7 : 272, 2016.
-
11.
Calcuttawala MA , Bendre M & Menon N: Role of platelet rich plasma in treatment of diabetic foot ulcer. J Med Sci Clin Res 5 : 19961, 2017.
Efficacy of Intralesional Platelet-Rich Plasma in Diabetic Foot Ulcer
Search for other papers by Ajay Gupta in
Current site
Google Scholar
PubMed
Search for other papers by Chethan Channaveera in
Current site
Google Scholar
PubMed
Search for other papers by Satyaranjan Sethi in
Current site
Google Scholar
PubMed
Search for other papers by Sunil Ranga in
Current site
Google Scholar
PubMed
Search for other papers by Vijender Anand in
Current site
Google Scholar
PubMed
Background
Diabetic foot ulcer (DFU) is well managed by infection control, euglycemic state, and debridement of the ulcer followed by appropriate dressing and off-loading of the foot. Studies show that approximately 90% of DFUs that are properly off-loaded heal in nearly 6 weeks. Platelet-rich plasma (PRP) serves as a growth factor agonist and has mitogenic and chemotactic properties that help in DFU healing. We sought to evaluate the efficacy of local application of PRP with respect to healing rate and ulcer area reduction in treating DFUs.
Methods
Sixty noninfected patients with DFUs (plantar surface area, ≤20 cm2; Meggitt-Wagner grades 1 and 2) were randomized to receive normal saline dressing (control group [CG]) or PRP dressing (study group [SG]) along with total-contact casting for 6 weeks or until complete ulcer healing, whichever was earlier. Healing rate and change in ulcer area were evaluated weekly.
Results
Mean ± SD ulcer area at baseline was 4.96 ± 2.89 cm2 (CG) and 5.22 ± 3.82 cm2 (SG) (P = .77), decreasing to 1.15 ± 1.35 cm2 (CG) and 0.96 ± 1.53 cm2 (SG) (P = .432) at 6 weeks. Mean ± SD percentage reduction in healing area at 6 weeks was 81.72% ± 17.2% (CG) and 85.98% ± 13.42% (SG) (P = .29). Mean ± SD healing rate at 6 weeks was 0.64 ± 0.36 cm2 (CG) and 0.71 ± 0.46 cm2 (SG) (P = .734).
Conclusions
The PRP dressing is no more efficacious than normal saline dressing in the management of DFU in conjunction with total-contact casting.
Department of Physical Medicine and Rehabilitation, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
advertising
advertising
