• 1.

    Oliveira AM, Perez-Atayde AR & Inwards CY et al.: USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol 165: 1773, 2004.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Arora S, Sabat D & Arora SK et al.: Primary aneurysmal bone cyst of the proximal tibia crossing the open physis. J Orthop Sci 16: 665, 2011.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 3.

    Carlson DH, Wilkinson RH & Bhakkaviziam A: Aneurysmal bone cysts in children. AJR Am J Roentgenol 116: 644, 1972.

  • 4.

    Dyer R, Stelling CB & Fechner RE: Epiphyseal extension of an aneurysmal bone cyst. AJR Am J Roentgenol 137: 172, 1981.

  • 5.

    McCarthy SM & Ogden JA: Epiphyseal extension of an aneurysmal bone cyst. J Pediatr Orthop 2: 171, 1982.

  • 6.

    Ramírez AR & Stanton RP: Aneurysmal bone cyst in 29 children. J Pediatr Orthop 22: 533, 2002.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 7.

    Capanna R, Springfield DS & Biagini R et al.: Juxtaepiphyseal aneurysmal bone cyst. Skeletal Radiol 13: 21, 1985.

  • 8.

    Rizzo M, Dellaero DT & Harrelson JM et al.: Juxtaphyseal aneurysmal bone cysts. Clin Orthop Rel Res 364: 205, 1999.

    • Crossref
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 9.

    Bonakdarpour A, Levy WM & Aegerter E: Primary and secondary aneurysmal bone cyst: a radiological study of 75 cases. Radiology 126: 75, 1978.

  • 10.

    Capanna R, Campanacci DA & Manfrini M: Unicameral and aneurysmal bone cysts. Orthop Clin North Am 27: 605, 1996.

  • 11.

    Šekoranja D, Zupan A & Mavčič B et al.: Novel ASAP1-USP6, FAT1-USP6, SAR1A-USP6, and TNC-USP6 fusions in primary aneurysmal bone cyst. Genes Chromosomes Cancer 59: 357, 2020.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 12.

    Campanacci M, Capanna R & Picci P: Unicameral and aneurysmal bone cysts. Clin Orthop Relat Res 204: 25, 1986.

  • 13.

    Gong L, Bui MM & Zhang W et al.: H3F3A G34 mutation DNA sequencing and G34W immunohistochemistry analysis in 366 cases of giant cell tumors of bone and other bone tumors. Histol Histopathol 36: 61, 2021.

    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 14.

    Shooshtarizadeh T, Movahedinia S & Mostafavi H et al.: Aneurysmal bone cyst: an analysis of 38 cases and report of 4 unusual surface ones. Arch Bone Jt Surg 4: 166, 2016.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Aycan OE, Çamurcu IY & Özer D et al.: Unusual localizations of unicameral bone cysts and aneurysmal bone cysts: a retrospective review of 451 cases. Acta Orthop Belg 81: 209, 2015.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Kerimoĝlu S, Çitlak A & Kerimoĝlu G et al.: Primary aneurysmal bone cyst of the distal tibial epiphysis: a case report. J Pediatr Orthop B 23: 266, 2014.

    • Crossref
    • PubMed
    • Web of Science
    • Search Google Scholar
    • Export Citation
  • 17.

    Norton KI, Hermann G & Abdelwahab IF et al.: Epiphyseal involvement in osteosarcoma. Radiology 180: 813, 1991.

  • 18.

    Wing-Hoi C, Kwong-Man L & Kwok-Pui F et al.: TGF-1 is the factor secreted by proliferative chondrocytes to inhibit neo-angiogenesis. J Cell Biochem 81: 79, 2001.

  • 19.

    Quan GM, Ojaimi J & Nadesapillai AP et al.: Resistance of epiphyseal cartilage to invasion by osteosarcoma is likely to be due to expression of antiangiogenic factors. Pathobiology 70 : 361, 20022003.

    • Search Google Scholar
    • Export Citation
  • 20.

    Tsagozis P & Brosjö O: Current strategies for the treatment of aneurysmal bone cysts. Orthop Rev (Pavia) 7: 6182, 2015.

Primary Aneurysmal Bone Cyst of the Distal Tibia Crossing the Open Physis

Sumit Arora MS(Ortho), DNB(Ortho), MRCPS(Glasgow), MNAMS, Yasim Khan MS(Ortho), Vijay RK MS(Ortho), Sumit Sural MS(Ortho), and Anil Dhal MS(Ortho)
View More View Less
Restricted access

Crossing the barrier of an open physis by primary aneurysmal bone cyst is an exceptional phenomenon. We present a rare case of primary active aneurysmal bone cyst of the distal tibia in a 15-year-old boy in whom the lesion had crossed the open lateral distal tibia physis. The diagnosis was confirmed by radiographs, computed tomography, magnetic resonance imaging, and histopathologic findings. The lesion was successfully treated by extended curettage and allograft impaction. The patient was asymptomatic when last seen at 30 months.

Department of Orthopaedic Surgery, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India.

Corresponding author: Sumit Arora, MS(Ortho), DNB(Ortho), MRCPS(Glasgow), MNAMS, Department of Orthopaedic Surgery, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi 110002, India. (E-mail: mamc_309@yahoo.co.in)