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1
Jennette JC, Falk RJ, Bacon PA, et al: 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Arthritis Rheum 65: 1, 2013.
-
2
Sokolowska BM, Szczeklik WK, Wludarczyk AA, et al: ANCA-positive and ANCA-negative phenotypes of eosinophilic granulomatosis with polyangiitis (EGPA): outcome and long-term follow-up of 50 patients from a single Polish center. Clin Exp Rheumatol 32(suppl 82): S41, 2014.
-
3
García-Melchor E, Mínguez Blasco S, Moltó Revilla A, et al: Churg-Strauss vasculitis. Description of 9 cases. Reumatol Clin 6: 76, 2010.
-
4
Katerenchuk IP, Tkachenko LA, Yarmola TI, et al: Churg-Strauss syndrome: clinical case and its feautures. Wiad Lek 72: 723, 2019.
-
5
Abril A. Churg-Strauss syndrome: an update. Curr Rheumatol Rep 13: 489, 2011.
-
6
Sinico RA, Bottero P: “Eosinophilic Granulomatosis with Polyangiitis (Churg-Straus Syndrome)” in Systemic Vasculitides: Current Status and Perspectives, edited by F Dammacco, D Ribatti, A Vacca, p 129, Springer, Cham, 2016.
-
7
Yılmaz İ, Tutar N, Şimşek ZÖ, et al: Clinical and serological features of eosinophilic and vasculitic phases of eosinophilic granulomatosis with poliangiitis: a case series of 15 patients. Turk Thorac J 18: 72, 2017.
-
8
Masi AT, Hunder GG, Lie JT, et al: The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis & angiitis). Arthritis Rheum 33: 1094, 1990.
-
9
Furuta S, Iwamoto T, Nakajima H: Update on eosinophilic granulomatosis with polyangiitis. Allergol Int 68: 430, 2019.
-
10
Kararizou E, Davaki P, Spengos K, et al: Churg-Strauss syndrome complicated by neuropathy: a clinicopathological study of nine cases. Clin Neuropathol 30: 11, 2011.
-
11
Nishi R, Koike H, Ohyama K, et al: Differential clinicopathologic features of EGPA-associated neuropathy with and without ANCA. Neurology 94: e1726, 2020.
-
12
Ishaq U, Malik J, Baig A, et al: Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) mimicking a stroke and acute coronary syndrome: a case report. Cureus 12: e8984, 2020.
-
13
Jeong W, Yun SH, Kim JS: Differential diagnosis of Churg-Strauss syndrome with tingling sensation and weakness of the lower extremities. Anesth Pain Med 8: e84179, 2018.
Uncovering Eosinophilic Granulomatosis with Polyangiitis in Clinical Practice
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Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) is a small- to medium-vessel vasculitis associated with asthma and eosinophilia. If left untreated, it can lead to systemic complications with a high mortality rate. The authors present a case of eosinophilic granulomatosis with polyangiitis that initially presented with adult-onset asthma, asymmetric neuropathy to the right lower extremity, and erythematous maculopapular cutaneous lesions to bilateral lower extremities. Through an extensive work-up, the diagnosis of eosinophilic granulomatosis with polyangiitis was made. Steroid therapy was initiated, causing his eosinophil count to return to normal and his presenting symptoms to improve, although his neuropathy and weakness remained. It is our hope that presenting this unusual condition manifesting in the lower extremity can provide guidance to clinicians who might encounter this condition and help them to recognize and treat it before severe chronic complications can manifest.
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