• 1

    Hazarika D, Jahan N, Sharma A: Changing trend of superficial mycoses with increasing nondermatophyte mold infection: a clinicomycological study at a tertiary referral center in Assam. Indian J Dermatol 64: 261, 2019.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 2

    Gupta AK, Venkataraman M, Renaud HJ, et al: A paradigm shift in the treatment and management of onychomycosis. Skin Appendage Disord 7: 351, 2021.

  • 3

    Gupta AK, Versteeg SG, Shear NH, et al: A practical guide to curing onychomycosis: how to maximize cure at the patient, organism, treatment, and environmental level. Am J Clin Dermatol 20: 123, 2019.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 4

    Page MJ, McKenzie JE, Bossuyt PM, et al: The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372: n71, 2021.

  • 5

    Hsu AR, Hsu JW: Topical review: skin infections in the foot and ankle patient. Foot Ankle Int 33: 612, 2012.

  • 6

    Gupta AK, Studholme C: Novel investigational therapies for onychomycosis: an update. Expert Opin Investig Drugs 25: 297, 2016.

  • 7

    Tosti A, Elewski BE: Onychomycosis: practical approaches to minimize relapse and recurrence. Skin Appendage Disord 2: 83, 2016.

  • 8

    Davies HD, Jackson MA, Rice SG, et al: Infectious diseases associated with organized sports and outbreak control. Pediatrics 140: e20172477, 2017.

  • 9

    Gupta AK, Versteeg SG, Shear NH: Onychomycosis in the 21st century: an update on diagnosis, epidemiology, and treatment. J Cutan Med Surg 21: 525, 2017.

  • 10

    Gupta AK, Foley KA, Versteeg SG: New antifungal agents and new formulations against dermatophytes. Mycopathologia 182: 127, 2017.

  • 11

    Daggett C, Brodell RT, Daniel CR, et al: Onychomycosis in athletes. Am J Clin Dermatol 20: 691, 2019.

  • 12

    Gupta AK, Versteeg SG: The role of shoe and sock sanitization in the management of superficial fungal infections of the feet. JAPMA 109: 141, 2019.

  • 13

    Gupta AK, Stec N, Summerbell RC, et al: Onychomycosis: a review. J Eur Acad Dermatol Venereol 34: 1972, 2020.

  • 14

    Nowicka D, Nawrot U: Tinea pedis—an embarrassing problem for health and beauty—a narrative review. Mycoses 64: 1140, 2021.

  • 15

    Dixon HA: The study of fungi in diseases of the skin. Can Med Assoc J 14: 1097, 1924.

  • 16

    Ameen M, Lear JT, Madan V, et al: British Association of Dermatologists’ guidelines for the management of onychomycosis 2014. Br J Dermatol 171: 937, 2014.

  • 17

    Silva-Neves V, Hugo V, Alves P, et al: Quality of life and therapeutic regimen management in onychomycosis patients and in vitro study of antiseptic solutions. Sci Rep 11: 12789, 2021.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18

    Takehara K, Oe M, Tsunemi Y, et al: Factors associated with presence and severity of toenail onychomycosis in patients with diabetes: a cross-sectional study. Int J Nurs Stud 48: 1101, 2011.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19

    Milles CL, Riley PA, Kessenich CR: Onychomycosis: diagnosis and systemic treatment. Nurse Pract 23: 40, 1998.

  • 20

    Ilkit M, Tanır F, Hazar S, et al: Epidemiology of tinea pedis and toenail tinea unguium in worshippers in the mosques in Adana, Turkey. J Dermatol 32: 698, 2005.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21

    Raboobee N, Aboobaker J, Peer AK, et al: Tinea pedis et unguium in the Muslim community of Durban, South Africa. Int J Dermatol 37: 759, 1998.

  • 22

    Cohen AD, Wolak A, Alkan M, et al: Prevalence and risk factors for tinea pedis in Israeli soldiers. Int J Dermatol 44: 1002, 2005.

  • 23

    Alsaif F, Somily A, Balbeesi A, et al: Are mosque carpets’ reservoirs for fungi causing superficial foot mycosis? A cross-sectional study in Riyadh, Saudi Arabia. Environ Sci Pollut Res Int 27: 38695, 2020.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24

    Hilmarsdottir I, Haraldsson H, Sigurdardottir A, et al: Dermatophytes in a swimming pool facility: difference in dermatophyte load in men’s and women’s dressing rooms. Acta Derm Venereol 85: 267, 2005.

    • Search Google Scholar
    • Export Citation
  • 25

    Borkow G, Gabbay J: Putting copper into action: copper-impregnated products with potent biocidal activities. FASEB J 18: 1728, 2004.

  • 26

    Borkow G, Mellibovsky JC: Resolution of skin maladies of the trapped Chilean miners: the unplanned underground copper-impregnated antifungal socks “trial.” Arch Dermatol 148: 134, 2012.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27

    Borkow G: Protection of soldiers’ feet by copper oxide impregnated socks. Adv Mil Technol 8: 101, 2013.

  • 28

    Zatcoff RC, Smith MS, Borkow G: Treatment of tinea pedis with socks containing copper-oxide impregnated fibers. Foot (Edinb) 18: 136, 2008.

  • 29

    Shirakawa M: Experimental studies on the application of some bactericides and fungicides from the viewpoint of clothes sanitation. Kurume Med J 6: 41, 1959.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 30

    Shirakawa M: Experimental studies on the application of some bactericides and fungicides from the viewpoint of clothes sanitation II. On the residual effects of the pentachlorophenol mixed in the insoles of canvas shoes after washing. Kurume Med J 6: 51, 1959.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 31

    Shirakawa M: Experimental studies on the application of some bactericides and fungicides from the viewpoint of clothes sanitation III. On the effects of pentachlorophenol mixed in the insoles of canvas shoes to various bacteria and eumycetes. Kurume Med J 6: 111, 1959.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 32

    Hammer TR, Mucha H, Hoefer D: Dermatophyte susceptibility varies towards antimicrobial textiles. Mycoses 55: 344, 2012.

  • 33

    Sanada H, Nakagami G, Takehara K, et al: Antifungal effect of non-woven textiles containing polyhexamethylene biguanide with sophorolipid: a potential method for tinea pedis prevention. Healthcare (Basel) 2: 183, 2014.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 34

    Yuen CWM, Yip J, Cheung HC, et al: Treatment of interdigital-type tinea pedis with a 2-week regimen of wearing hygienic socks loaded with antifungal microcapsules: a randomized, double-blind, placebo-controlled study. J Am Acad Dermatol 69: 495, 2013.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35

    Tarbuk A, Grancarić AM, Magaš S: Modified cotton socks—possibility to protect from diabetic foot infection. Coll Antropol 39: 177, 2015.

  • 36

    Gupta AK, Ahmad I, Summerbell RC: Comparative efficacies of commonly used disinfectants and antifungal pharmaceutical spray preparations against dermatophytic fungi. Med Mycol 39: 321, 2001.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 37

    Feuilhade de Chauvin M: A study on the decontamination of insoles colonized by Trichophyton rubrum: effect of terbinafine spray powder 1% and terbinafine spray solution 1%. J Eur Acad Dermatol Venereol 26: 875, 2012.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 38

    Warshaw EM, St Clair KR: Prevention of onychomycosis reinfection for patients with complete cure of all 10 toenails: results of a double-blind, placebo-controlled, pilot study of prophylactic miconazole powder 2%. J Am Acad Dermatol 53: 717, 2005.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 39

    Stapleton K, Hill K, Day K, et al: The potential impact of washing machines on laundry malodour generation. Lett Appl Microbiol 56: 299, 2013.

  • 40

    Babič MN, Zalar P, Ženko B, et al: Candida and Fusarium species known as opportunistic human pathogens from customer-accessible parts of residential washing machines. Fungal Biol 119: 95, 2015.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41

    Hammer TR, Mucha H, Hoefer D: Infection risk by dermatophytes during storage and after domestic laundry and their temperature-dependent inactivation. Mycopathologia 171: 43, 2011.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42

    Honisch M, Stamminger R, Bockmühl DP: Impact of wash cycle time, temperature and detergent formulation on the hygiene effectiveness of domestic laundering. J Appl Microbiol 117: 1787, 2014.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 43

    Brands B, Brinkmann A, Bloomfield S, et al: Microbicidal action of heat, detergents and active oxygen bleach as components of laundry hygiene. Tenside Surfactants Deterg 53: 495, 2016.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 44

    English MP, Wethered RR, Duncan EH: Studies in the epidemiology of tinea pedis. 8. Fungal infection in a long-stay hospital. Br Med J 3: 136, 1967.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 45

    Jung WK, Kim SH, Koo HC, et al: Antifungal activity of the silver ion against contaminated fabric. Mycoses 50: 265, 2007.

  • 46

    Tanaka K, Katoh T, Irimajiri J, et al: Preventive effects of various types of footwear and cleaning methods on dermatophyte adhesion. J Dermatol 33: 528, 2006.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47

    Amichai B, Grunwald MH, Davidovici B, et al: The effect of domestic laundry processes on fungal contamination of socks. Int J Dermatol 52: 1392, 2013.

  • 48

    Schages J, Stamminger R, Bockmühl DP: A new method to evaluate the antimicrobial efficacy of domestic laundry detergents. J Surfactants Deterg 23: 629, 2020.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 49

    Blaser MJ, Smith PF, Cody HJ, et al: Killing of fabric-associated bacteria in hospital laundry by low-temperature washing. J Infect Dis 149: 48, 1984.

  • 50

    Moriello KA: Decontamination of laundry exposed to Microsporum canis hairs and spores. J Feline Med Surg 18: 457, 2016.

  • 51

    Jamieson RC, McCrea A: Shoes: a source of reinfection in ringworm of the feet. Arch Dermatol Syph 35: 203, 1937.

  • 52

    Amichai B, Grunwald MH, Davidovici B, et al: “Sunlight is said to be the best of disinfectants”*: the efficacy of sun exposure for reducing fungal contamination in used clothes. Isr Med Assoc J 16: 431, 2014.

    • Search Google Scholar
    • Export Citation
  • 53

    Messina G, Burgassi S, Russo C, et al: Is it possible to sanitize athletes’ shoes? J Athl Train 50: 126, 2015.

  • 54

    Dai T, Tegos GP, Rolz-Cruz G, et al: Ultraviolet C inactivation of dermatophytes: implications for treatment of onychomycosis. Br J Dermatol 158: 1239, 2008.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 55

    Ghannoum MA, Isham N, Long L: Optimization of an infected shoe model for the evaluation of an ultraviolet shoe sanitizer device. JAPMA 102: 309, 2012.

  • 56

    Cronin LJ, Mildren RP, Moffitt M, et al: An investigation into the inhibitory effect of ultraviolet radiation on Trichophyton rubrum. Lasers Med Sci 29: 157, 2013.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 57

    Nematollahi AR, Badiee P, Nournia E: The efficacy of ultraviolet irradiation on Trichophyton species isolated from nails. Jundishapur J Microbiol 8: e18158, 2015.

  • 58

    Cadnum JL, Shaikh AA, Piedrahita CT, et al: Relative resistance of the emerging fungal pathogen Candida auris and other Candida species to killing by ultraviolet light. Infect Control Hosp Epidemiol 39: 94, 2018.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 59

    Gupta AK, Brintnell WC: Sanitization of contaminated footwear from onychomycosis patients using ozone gas: a novel adjunct therapy for treating onychomycosis and tinea pedis? J Cutan Med Surg 17: 243, 2013.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 60

    Gupta AK, Brintnell WC: Ozone gas effectively kills laboratory strains of Trichophyton rubrum and Trichophyton mentagrophytes using an in vitro test system. J Dermatol Treat 25: 251, 2014.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 61

    Ouf SA, Moussa TA, Abd-Elmegeed AM, et al: Anti-fungal potential of ozone against some dermatophytes. Braz J Microbiol 47: 697, 2016.

  • 62

    Zargaran M, Fatahinia M, Zarei Mahmoudabadi A: The efficacy of gaseous ozone against different forms of Candida albicans. Curr Med Mycol 3: 26, 2017.

  • 63

    Daeschlein G, Scholz S, von Woedtke T, et al: In vitro killing of clinical fungal strains by low-temperature atmospheric-pressure plasma jet. IEEE Trans Plasma Sci 39: 815, 2011.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 64

    Budihardja D, Mayser P: The effect of microwave irradiation on the vitality of various dermatophytes. Mycoses 57: 209, 2014.

  • 65

    Scacchetti FAP, Pinto E, Soares G: Functionalization and characterization of cotton with phase change materials and thyme oil encapsulated in beta-cyclodextrins. Prog Org Coat 107: 64, 2017.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 66

    Walentowska J, Foksowicz-Flaczyk J: Thyme essential oil for antimicrobial protection of natural textiles. Int Biodeterior Biodegrad 84: 407, 2013.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 67

    Mamun AA, Hasan R, Ahmed R, et al: Antifungal efficacy of neem leaves (Azadirachta indica) and mahagony fruit bark (Swietenia mahagoni) extracts on leather shoes. Bangladesh J Sci Ind Res 54: 257, 2019.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 68

    Borkow G: Using copper to improve the well-being of the skin. Curr Chem Biol 8: 89, 2014.

  • 69

    Hedayati N, Montazer M, Mahmoudirad M, et al: Ketoconazole and ketoconazole/β-cyclodextrin performance on cotton wound dressing as fungal skin treatment. Carbohydr Polym 240: 116267, 2020.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • 70

    Mosca R, Mosca M, Revetria R, et al: Sanitizing of confined spaces using gaseous ozone produced by 4.0 machines. In: Proceedings of the World Congress on Engineering 2021. Available at: http://www.iaeng.org/publication/WCE2021/WCE2021_pp340-345.pdf. Accessed November 12, 2021.

    • Search Google Scholar
    • Export Citation
  • 71

    Scholtz V, Julák J, Kříha V: The microbicidal effect of low-temperature plasma generated by corona discharge: comparison of various microorganisms on an agar surface or in aqueous suspension. Plasma Process Polym 7: 237, 2010.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • 72

    Sun Y, Yu S, Sun P, et al.. Inactivation of Candida biofilms by non-thermal plasma and its enhancement for fungistatic effect of antifungal drugs. PLoS One 7: e40629, 2012.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation

The March Against Onychomycosis: A Systematic Review of the Sanitization Methods for Shoes, Socks, and Textiles

Aditya K. Gupta MD, PhD, FRCP(C)1,2, Aaron J. Simkovich PhD1, and Deanna C. Hall PhD1
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  • 1 Mediprobe Research Inc, London, Ontario, Canada.
  • | 2 Department of Medicine, Division of Dermatology, University of Toronto School of Medicine, Toronto, Ontario, Canada.
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Drug-based treatment of superficial fungal infections, such as onychomycosis, is not the only defense. Sanitization of footwear such as shoes, socks/stockings, and other textiles is integral to the prevention of recurrence and reduction of spread for superficial fungal mycoses. The goal of this review was to examine the available methods of sanitization for footwear and textiles against superficial fungal infections. A systematic literature search of various sanitization devices and methods that could be applied to footwear and textiles using PubMed, Scopus, and MEDLINE was performed. Fifty-four studies were found relevant to the different methodologies, devices, and techniques of sanitization as they pertain to superficial fungal infections of the feet. These included topics of basic sanitization, antifungal and antimicrobial materials, sanitization chemicals and powder, laundering, ultraviolet, ozone, nonthermal plasma, microwave radiation, essential oils, and natural plant extracts. In the management of onychomycosis, it is necessary to think beyond treatment of the nail, as infections enter through the skin. Those prone to onychomycosis should examine their environment, including surfaces, shoes, and socks, and ensure that proper sanitization is implemented.

Corresponding author: Aditya K. Gupta, MD, PhD, FRCP(C), Mediprobe Research Inc, 645 Windermere Rd, London, Ontario N5X 2P1, Canada. (E-mail: agupta@mediproberesearch.com)