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-
1.
Ratushny V, Gober MD, Hick R, et al: From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest 122: 464, 2012.
-
2.
Sanderson RJ, Ironside JAD: Squamous cell carcinomas of the head and neck. BMJ 325: 822, 2002.
-
3.
American Cancer Society: Basal and squamous cell skin cancer causes, risk factors, and prevention. Available at: https://www.cancer.org/cancer/types/basal-and-squamous-cell-skin-cancer/causes-risks-prevention.html.
-
4.
David MG, Stumph J, David BM: Primary squamous cell carcinoma of the distal hallux. JAPMA 103: 149, 2013.
-
5.
Torre LA, Bray F, Siegel RL, et al: Global cancer statistics, 2012. CA Cancer J Clin 65: 87, 2015.
-
6.
Clayman GL, Lee JJ, Holsinger FC, et al: Mortality risk from squamous cell skin cancer. J Clin Oncol 23: 759, 2005.
-
7.
Nguyen KD, Han J, Li T, et al: Invasive cutaneous squamous cell carcinoma incidence in US health care workers. Arch Dermatol Res 306: 555, 2014.
-
8.
Housman TS, Feldman SR, Williford PM, et al: Skin cancer is among the most costly of all cancers to treat for the Medicare population. J Am Acad Dermatol 48: 425, 2003.
-
9.
Howard D, Rigby R, Winegar K: Primary high-grade squamous cell carcinoma of the foot: a case report. JAPMA 104: 514, 2014.
-
10.
Khaladj M, Mbibong R-M, Shah N, et al: Invasive squamous cell carcinoma with osteomyelitis of the foot: a case report. JAPMA 105: 374, 2015.
-
11.
Solus JF, Murphy GF, Kraft S: Cutaneous squamous cell carcinomas of the lower extremities show distinct clinical and pathologic features. Int J Surg Pathol 24: 29, 2016.
-
12.
Kirby EJ, Shereff MJ, Lewis MM: Soft-tissue tumors and tumor-like lesions of the foot: an analysis of eighty-three cases. J Bone Joint Surg Am 71: 621, 1989.
-
13.
Henning J, Rasor Z, Brown A, et al: Primary invasive squamous cell carcinoma of the foot. JAPMA 110: Article_13, 2020.
-
14.
Brodland DG, Zitelli JA: Surgical margins for excision of primary cutaneous squamous cell carcinoma. J Am Acad Dermatol 27: 241, 1992.
-
15.
Theodorou SJ, Theodorou DJ, Bona SJ, et al: Primary squamous cell carcinoma: an incidental toe mass. AJR Am J Roentgenol 184(suppl): S110, 2005.
-
16.
Wani I: Metastatic squamous cell carcinoma of foot: case report. Oman Med J 24: 49, 2009.
-
17.
Sheen Y-S, Sheen M-C, Sheu H-M, et al: Squamous cell carcinoma of the big toe successfully treated by intra-arterial infusion with methotrexate. Dermatol Surg 29: 982, 2003.
An Aggressively Recurrent Squamous Cell Carcinoma of the Foot
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Squamous cell carcinoma is a malignant tumor that is most commonly found on the head and neck. The current global incidence of squamous cell carcinoma at any site is estimated to be more than 1 million cases per year, with a reported 3-year mortality rate of 30%. Recurrence of squamous cell carcinoma at any site is estimated to be 15% to 50% and has been associated with greater rates of infiltration, perineural invasion, and mortality. Recent studies have shown lower-extremity squamous cell carcinoma to be distinct from squamous cell carcinoma at any site with histologic and clinical differences. Lower-extremity squamous cell carcinoma is suggestively less aggressive and carries less risk of metastasis. However, lower-extremity squamous cell carcinoma prevalence, mortality, and recurrence rates have not been extensively studied. The present report depicts a case of recurrent squamous cell carcinoma originating in 2006 in the dorsal forefoot and provides the clinical management of subsequent recurrence episodes, with excisions from 2015 and 2020.
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