• 1.

    Ribeiro AP, Trombini-Souza F, Tessutti VD, et al: The effects of plantar fasciitis and pain on plantar pressure distribution of recreational runners. Clin Biomech 26: 194, 2011.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Riddle DL, Pulisic M, Pidcoe P, et al: Risk factors for plantar fasciitis: a matched case-control study. J Bone Joint Surg Am 85: 872, 2003.

  • 3.

    Goff JD, Crawford R: Diagnosis and treatment of plantar fasciitis. Am Fam Physician 84: 676, 2011.

  • 4.

    Hossain M, Makwana N: “Not plantar fasciitis”: the differential diagnosis and management of heel pain syndrome. Orthop Trauma 25: 198, 2011.

  • 5.

    Sorrentino F, Iovane A, Vetro A, et al: Role of high-resolution ultrasound in guiding treatment of idiopathic plantar fasciitis with minimally invasive techniques. Radiol Med 113: 486, 2008.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Palomo-López P, Becerro-de-Bengoa-Vallejo R, Losa-Iglesias ME, et al: Impact of plantar fasciitis on the quality of life of male and female patients according to the Foot Health Status Questionnaire. J Pain Res 11: 875, 2018.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7.

    Healey K, Chen K: Plantar fasciitis: current diagnostic modalities and treatments. Clin Podiatr Med Surg 27: 369, 2010.

  • 8.

    Thomas JL, Christensen JC, Kravitz SR, et al: The diagnosis and treatment of heel pain: a clinical practice guideline–revision 2010. J Foot Ankle Surg 49: S1, 2010.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Kuyucu E, Koçyiğit F, Erdil M: The association of calcaneal spur length and clinical and functional parameters in plantar fasciitis. Int J Surg 21: 28, 2015.

  • 10.

    Tong KB, Furia J: Economic burden of plantar fasciitis treatment in the United States. Am J Orthop (Belle Mead NJ) 39: 227, 2010.

  • 11.

    Buchbinder R: Plantar fasciitis. N Engl J Med 350: 2159, 2004.

  • 12.

    Abboud JA, Kim JS: The effect of hypercholesterolemia on rotator cuff disease. Clin Orthop Relat Res 468: 1493, 2010.

  • 13.

    Ozgurtas T, Yildiz C, Serdar M, et al: Is high concentration of serum lipids a risk factor for Achilles tendon rupture? Clin Chim Acta 331: 25, 2003.

  • 14.

    Lee SH, Gong HS, Kim S, et al: Is there a relation between lateral epicondylitis and total cholesterol levels? Arthroscopy 35: 1379, 2019.

  • 15.

    Abboud JA, Beason DP, Soslowsky LJ: Emerging ideas: the effect of hypercholesterolemia on tendons. Clin Orthop Relat Res 470: 317, 2012.

  • 16.

    Scott A, Zwerver J, Grewal N, et al: Lipids, adiposity and tendinopathy: is there a mechanistic link? critical review. Br J Sports Med 49: 984, 2015.

  • 17.

    Aicale R, Tarantino D, Maffulli N: Overuse injuries in sport: a comprehensive overview. J Orthop Surg Res 13: 1, 2018.

  • 18.

    Çatal B, Genç E, Çaçan MA, et al: Is there a relation between plantar fasciitis and total cholesterol levels? Foot Ankle Surg 28: 390, 2022.

  • 19.

    Neufeld SK, Cerrato R: Plantar fasciitis: evaluation and treatment. J Am Acad Orthop Surg 16: 338, 2008.

  • 20.

    Tilley BJ, Cook JL, Docking SI, et al: Is higher serum cholesterol associated with altered tendon structure or tendon pain? a systematic review. Br J Sports Med 49: 1504, 2015.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 21.

    Józsa L, Réffy A, Bálint JB: The pathogenesis of tendolipomatosis; an electron microscopical study. Int Orthop 7: 251, 1984.

  • 22.

    Rönnemaa T, Juva K, Kulonen E: Effect of hyperlipidemic rat serum on the synthesis of collagen by chick embryo fibroblasts. Atherosclerosis 21: 315, 1975.

  • 23.

    Hamburg NM, McMackin CJ, Huang AL, et al: Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol 27: 2650, 2007.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Olsen RH, Krogh-Madsen R, Thomsen C, et al: Metabolic responses to reduced daily steps in healthy nonexercising men. JAMA 299: 1261, 2008.

  • 25.

    Steplewski A, Fertala J, Tomlinson R, et al: The impact of cholesterol deposits on the fibrillar architecture of the Achilles tendon in a rabbit model of hypercholesterolemia. J Orthop Surg Res 14: 1, 2019.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    De Oliveira L, Vieira C, Guerra F, et al: Structural and biomechanical changes in the Achilles tendon after chronic treatment with statins. Food Chem Toxicol 77: 50, 2015.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 27.

    Priesand SJ, Schmidt BM, Ang L, et al: Plantar fasciitis in patients with type 1 and type 2 diabetes: a contemporary cohort study. J Diabetes Complications 33: 107399, 2019.

    • PubMed
    • Search Google Scholar
    • Export Citation

Comparison of Lipid and Glucose Levels in Individuals with and Without Plantar Fasciitis: A Cross-Sectional Observational Study

Sayyed-Hadi Sayyed-Hosseinian Massachusetts General Hospital, Boston, MA.

Search for other papers by Sayyed-Hadi Sayyed-Hosseinian in
Current site
Google Scholar
PubMed
Close
 MD
,
Farshid Bagheri Orthopedic Research Center, Shahid Kamyab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Search for other papers by Farshid Bagheri in
Current site
Google Scholar
PubMed
Close
 MD
,
Fatemeh Sistanian Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Search for other papers by Fatemeh Sistanian in
Current site
Google Scholar
PubMed
Close
 MD
,
Alireza Mousavian Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Search for other papers by Alireza Mousavian in
Current site
Google Scholar
PubMed
Close
 MD
,
Mohammad Hosein Ebrahimzadeh Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Search for other papers by Mohammad Hosein Ebrahimzadeh in
Current site
Google Scholar
PubMed
Close
 MD
,
Amir Reza Kachooei Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Search for other papers by Amir Reza Kachooei in
Current site
Google Scholar
PubMed
Close
 MD, PhD
, and
Mahla Daliri Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Search for other papers by Mahla Daliri in
Current site
Google Scholar
PubMed
Close
 BO, MD

Background: Tendon problems and biomechanical alterations are linked to hyperlipidemia. We sought to determine the relationship of plantar fasciitis (PF) with lipid profile parameters and fasting blood sugar (FBS) levels.

Methods: In a case-control study, we enrolled 68 patients with a clinical diagnosis of PF in the case group and 136 individuals without PF in the control group. Patients’ height, weight, body mass index (BMI), FBS level, and lipid profile, including low-density lipoprotein (LDL-C), high-density lipoprotein, and total cholesterol levels and triglyceride levels, were compared between the groups. The mean difference of each variable between the patient and control groups was tested using an independent t test. We calculated the odds ratio to quantify the strength of association between PF and elevated lipid profile. Correlation coefficient analyses were used to calculate the correlation of patients’ BMI with lipid profile and FBS levels to evaluate the BMI variable as a confounder.

Results: Patients with PF had higher levels of total cholesterol (P = .001), LDL-C (P = .004), and triglycerides (P = .02). Odds ratio calculation showed that patients with serum LDL-C levels greater than 130 mg/dL were 3.3 times more likely to develop PF. We found no association between lipid profile parameters and BMI (as a confounder) in either group.

Conclusions: These findings show higher serum LDL-C parameters in patients with PF and may be sufficient to support a further clinical trial using statin treatment for persistent PF with increased LDL-C levels.

Corresponding author: Mahla Daliri, BO, MD, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, 9138813894, Iran. (E-mail: mahladalirib96@gmail.com)
Save