• 1.

    Turgut , Tubbs RS, Turgut M: Paul Hoffmann (1884–1962 AD) and Jules Tinel (1879–1952 AD), and their legacy to neuroscience: the Hoffmann-Tinel sign. Childs Nerv Syst 35: 733, 2019.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Sansone JM, Gatzke AM, Aslinia F, et al: Jules Tinel (1879–1952) and Paul Hoffmann (1884–1962). Clin Med Res 4: 85, 2006.

  • 3.

    Ho T, Braza ME: “Hoffmann tinel sign,” in StatPearls [Internet]. StatPearls Publishing, Treasure Island, FL, 2020.

  • 4.

    Walusinski O: Jules Tinel (1879–1952): Beyond the eponym, the man and his forgotten neurological contributions. Rev Neurol (Paris) 173: 364, 2017.

  • 5.

    Pietrzak K, Grzybowski A, Kaczmarczyk J: Jules Tinel (1879–1952). J Neurol 263: 1471, 2016.

  • 6.

    Tinel J: Le signe du fourmillement dans les lésions des nerfs périphériques. Presse Med 47: 388, 1915.

  • 7.

    Nathan P, Rennie AM: Value of Tinel sign. Lancet 247: 610, 1946.

  • 8.

    Datema M, Hoitsma E, Roon KI, et al: The Tinel sign has no diagnostic value for nerve entrapment or neuropathy in the legs. Muscle Nerve 54: 25, 2016.

  • 9.

    Wojewnik B, Bindra R: Cubital tunnel syndrome: review of current literature on causes, diagnosis and treatment. J Hand Microsurg 1: 76, 2009.

  • 10.

    Zhang D, Chruscielski CM, Blazar P, et al: Accuracy of provocative tests for carpal tunnel syndrome. J Hand Surg Glob Online 2: 121, 2020.

  • 11.

    Matsumoto J, Toyohiko I, Kyongsong K, et al: Clinical features and surgical treatment of superficial peroneal nerve entrapment neuropathy. Neurol Med Chir (Tokyo) 58: 320, 2018.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12.

    Fabre T, Piton C, Andre D, et al: Peroneal nerve entrapment. J Bone Joint Surg Am 80: 47, 1998.

  • 13.

    Lu JC-Y, Dengler J, Poppler LH, et al: Identifying common peroneal neuropathy before foot drop. Plast Reconstr Surg 146: 664, 2020.

  • 14.

    Parker RG: Dorsal foot pain due to compression of the deep peroneal nerve by exostosis of the metatarsocuneiform joint. JAPMA 95: 455, 2005.

  • 15.

    Lee CH, Dellon AL: Prognostic ability of Tinel sign in determining outcome for decompression surgery in diabetic and nondiabetic neuropathy. Ann Plast Surg 53: 523, 2004.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16.

    Rinkel WD, Cabezas MC, van Neck JW, et al: Validity of the Tinel sign and prevalence of tibial nerve entrapment at the tarsal tunnel in both diabetic and nondiabetic subjects: a cross-sectional study. Plast Reconstr Surg 142: 1258, 2018.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17.

    Ahmad M, Tsang K, Mackenney P, et al: Tarsal tunnel syndrome: a literature review. Foot Ankle Surg 18: 149, 2012.

  • 18.

    Flores AJ, Lavemia C, Owens PW: Anatomy and physiology of peripheral nerve injury and repair. Am J Orthop 29: 167, 2000.

  • 19.

    Dellon AL, Muse VL, Scott ND, et al: A positive Tinel sign as predictor of pain relief or sensory recovery after decompression of chronic tibial nerve compression in patients with diabetic neuropathy. J Reconstr Microsurg 28: 235, 2012.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    McGill D: Tarsal tunnel syndrome. Proc R Soc Med 57: 1125, 1964.

  • 21.

    Franson J, Baravarian B: Tarsal tunnel syndrome: a compression neuropathy involving four distinct tunnels. Clin Podiatr Med Surg 23: 597, 2006.

  • 22.

    Dellon AL: The four medial ankle tunnels: a critical review of perceptions of tarsal tunnel syndrome and neuropathy. Neurosurg Clin N Am 19: 629, 2008.

  • 23.

    DiGiovanni BF, Abuzzahab FS, Gould JS: Plantar fascia release with proximal and distal tarsal tunnel release: a surgical approach to chronic, disabling plantar fasciitis with associated nerve pain. Tech Foot Ankle Surg 2: 254, 2003.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 24.

    Baxter D, Schon L: “Assessment and Treatment of the Elite Athlete: Helpful Hints and Pertinent Pearls,” in Baxter's The Foot and Ankle in Sport, 2nd Ed, edited by DA Porter, LC Schon, Mosby, Philadelphia, 2008.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 25.

    Kennedy JG, Baxter DE: Nerve disorders in dancers. Clin Sports Med 27: 329, 2008.

  • 26.

    Baxter DE: “Functional Nerve Disorders,” in The Foot and Ankle in Sport, p 9, Mosby, St. Louis, 1995.

  • 27.

    Segura RP: Incidence of tarsal tunnel syndrome in a diabetic population: redefining topographic and electrophysiologic correlates. Paper presented at: 13th World Congress on Pain, 2010, Montreal.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 28.

    Segura RP, Nirenberg MS: High tibial nerve entrapment: a common component of tarsal tunnel syndrome. JAPMA 115: 1, 2025.

  • 29.

    Segura RP, Nirenberg MS: Prevalence of obesity in high tarsal tunnel syndrome: a cross-sectional study. JAPMA 113: 1, 2023.

  • 30.

    Oh SJ: Neuropathies of the foot. Clin Neurophysiol 118: 954, 2007.

  • 31.

    McSweeney SC, Cichero M: Tarsal tunnel syndrome: a narrative literature review. Foot 25: 244, 2015.

  • 32.

    Yunoki M: Analysis of surgical cases of tarsal tunnel syndrome in our department: case series and literature review. Asian J Neurosurg 15: 59, 2020.

  • 33.

    Fuller G: Neurological Examination Made Easy, 5th Ed, Churchill Livingstone, New York, 2013.

  • 34.

    Barrett S, Nickerson D, Elison P, et al: “The Association of Extremity Nerve Surgeons Clinical Practice Guidelines 2014,” in Practical Pain Management for the Lower Extremity Surgeon, edited by S Barrett, p 465, Data Trace Publishing Co, Towson, MD, 2015.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35.

    Trepman E, Kadel NJ, Chisholm K, et al: Effect of foot and ankle position on tarsal tunnel compartment pressure. Foot Ankle Int 20: 721, 1999.

  • 36.

    Kinoshita M, Okuda R, Morikawa J, et al: The dorsiflexion-eversion test for diagnosis of tarsal tunnel syndrome. J Bone Joint Surg Am 83: 1835, 2001.

  • 37.

    Abouelela AA, Zohiery AK: The triple compression stress test for diagnosis of tarsal tunnel syndrome. Foot 22: 146, 2012.

  • 38.

    Hendrix CL, Jolly GP, Garbalosa JC, et al: Entrapment neuropathy: the etiology of intractable chronic heel pain syndrome. J Foot Ankle Surg 37: 273, 1998.

  • 39.

    Fantino O: Role of ultrasound in posteromedial tarsal tunnel syndrome: 81 cases. J Ultrasound 17: 99, 2014.

  • 40.

    Therimadasamy A, Seet R, Kagda Y, et al: Combination of ultrasound and nerve conduction studies in the diagnosis of tarsal tunnel syndrome. Neurol India 59: 296, 2011.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41.

    Frey C, Kerr R: Magnetic resonance imaging and the evaluation of tarsal tunnel syndrome. Foot Ankle 14: 159, 1993.

  • 42.

    Oh SJ, Sarala PK, Kuba T, et al: Tarsal tunnel syndrome: electrophysiological study. Ann Neurol 5: 327, 1979.

  • 43.

    Almeida DF, Scremin L, Zúniga SF, et al: Focal conduction block in a case of tarsal tunnel syndrome. Muscle Nerve 42: 452, 2010.

  • 44.

    Campbell WW: The value of inching techniques in the diagnosis of focal nerve lesions: inching is a useful technique. Muscle Nerve 21: 1554, 1998.

  • 45

    Chun S-W, Lim S-K: The utility of electrodiagnostic inching study and conservative treatment in supracondylar process syndrome: a case report. Medicine 99: e20506, 2020.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46.

    Oexeman S, Arroyo CI, Rodriguez-Collazo ER, et al: Redefining the topography of the tibial nerve: updated treatment guide for tibial nerve entrapments: an addendum to surgical treatment protocol for peripheral nerve dysfunction of the lower extremity: a systematic approach. Clin Podiatr Med Surg 38: e7, 2021.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47.

    Felsenthal G, Butler DH, Shear MS: Across-tarsal-tunnel motor-nerve conduction technique. Arch Phys Med Rehabil 73: 64, 1992.

  • 48.

    Kimura J: Principles and pitfalls of nerve conduction studies. Ann Neurol 16: 415, 1984.

  • 49.

    Kimura J: New concepts for electrophysiologic assessments of peripheral nerve lesions. Japanese J Rehabil Med 40: 523, 2003.

  • 50.

    Brown W, Yates S: Percutaneous localization of conduction abnormalities in human entrapment neuropathies. Can J Neurol Sci 9: 391, 1982.

  • 51.

    Miller RG: The cubital tunnel syndrome: diagnosis and precise localization. Ann Neurol 6: 56, 1979.

  • 52.

    Kimura J: A method for determining median nerve conduction velocity across the carpal tunnel. J Neurol Sci 38: 1, 1978.

  • 53.

    Parker R: Parker Pass & MIS tarsal tunnel trifecta update. Paper presented at: Association of Extremity Nerve Surgeons Annual Symposium, November 2022, Fort Worth, TX.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 54.

    SharHashemi S, Cheikh I, Dellon AL: Prevalence of upper and lower extremity Tinel signs in diabetics: cross-sectional study from a United States, urban hospital-based population. J Diabetes Metab 4: 2, 2013.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 55.

    Shookster L, Falke GI, Ducic I, et al: Fibromyalgia and Tinel sign in the foot. JAPMA 94: 400, 2004.

  • 56.

    Dellon AL: Nerve decompression in diabetics with chronic nerve compression: update 2022. Plast Aesthet Res 9: 45, 2022.

  • 57.

    Mackinnon S, Dellon A, Daneshavar A: Tarsal tunnel syndrome: histopathologic examination of a human posterior tibial nerve. Contemp Orthop 9: 43, 1984.

  • 58.

    Lifchez SD, Means KR Jr, Dunn RE, et al: Intra-and inter-examiner variability in performing Tinel test. J Hand Surg 35: 212, 2010.

The Utility of the Tinel Sign in the Diagnosis of High Tarsal Tunnel Syndrome

Michael S. Nirenberg Friendly Foot Care PC, Crown Point, IN.

Search for other papers by Michael S. Nirenberg in
Current site
Google Scholar
PubMed
Close
 DPM
and
Roberto P. Segura Chicago Peripheral Nerve Center, Chicago, IL.

Search for other papers by Roberto P. Segura in
Current site
Google Scholar
PubMed
Close
 MD

Background: Tarsal tunnel syndrome (TTS) can be divided into distal and proximal components. The latter is referred to as high TTS (HTTS) in which the tibial nerve is compressed above the location of the laciniate ligament. Although diagnosis of TTS has been shown to be enhanced by elicitation of a positive Tinel sign, no research into the utility of this provocation test has been conducted in the diagnosis of HTTS. This study aims to investigate the usefulness of the Tinel sign in diagnosing HTTS.

Methods: Seventy patients with electrophysiologic confirmation of HTTS were evaluated for the presence of a positive Tinel sign over the posterior tibial nerve’s course in the area of the proximal tarsal tunnel (above the laciniate ligament).

Results: Of the 70 patients, 17 had a positive Tinel sign. Thirty-eight patients (54.3%) had electrodiagnostic evidence of polyneuropathy, and 12 of them (31.6%) had a positive Tinel sign. Among the 26 patients with HTTS and polyneuropathy who did not have a Tinel sign, electrodiagnostic testing found severe axonal dysfunction in ten. Fifteen of the patients with polyneuropathy were diagnosed as having diabetes mellitus, and a Tinel sign was present in 11 of them (73.3%). The four diabetic patients without a Tinel sign had marked axonal dysfunction (motor evoked responses were absent or significantly reduced).

Conclusions: The utility of the Tinel sign in patients with HTTS was found to be low; however, in the subpopulation of patients with diabetic neuropathy, the Tinel sign may be more useful.

Corresponding author: Michael S. Nirenberg, DPM, Friendly Foot Care PC, 50 W 94th Pl, Crown Point, IN 46307. (E-mail: info@friendlyfootcare.com)
Save