Cover Journal of the American Podiatric Medical Association
Journal of the American Podiatric Medical Association
ISSN:
8750-7315
Online Publication Date:
Jun 1990

Significance of capillary basement membrane changes in diabetes mellitus

RB Boyd Department of Anatomy, Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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JP Burke Department of Anatomy, Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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J Atkin Department of Anatomy, Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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VW Thompson Department of Anatomy, Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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JF Nugent Department of Anatomy, Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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DOI:
https://doi.org/10.7547/87507315-80-6-307
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Diabetes mellitus is a disease in which the capillary basement membranes are substantially altered. This diabetic microangiopathy is characterized by a thickening of the basement membrane and changes in its permeability characteristic due to a disturbance in the production and distribution of its functional components. Glucose metabolism and insulin imbalance have been implicated in these basement membrane modifications. The authors describe normal capillary basement membrane architecture and then discuss how pathologic changes caused by diabetes mellitus are related to diabetic foot pathology.

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