Cover Journal of the American Podiatric Medical Association
Journal of the American Podiatric Medical Association
ISSN:
8750-7315
Online Publication Date:
Sep 1991

Isolation of a stimulatory system in an Aloe extract

RH Davis Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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WL Parker Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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RT Samson Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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DP Murdoch Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

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DOI:
https://doi.org/10.7547/87507315-81-9-473
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The authors' previous work on a 50% ethanol extract of Aloe vera was done to evaluate anti-inflammatory activity using the croton oil-induced ear swelling assay. The anti-inflammatory activity was found in the supernatant fraction. The supernatant fraction decreased inflammation, when applied topically, by 29.2%, and the precipitate decreased inflammation by 12.1%. However, in the present work, the precipitate fraction decreased the wound diameter by an average of 47.1% (stimulatory system). Little or no wound healing activity was found in the supernatant. Aloe vera appears to act as a modulatory system toward wounds and inflammation and is a potentially valuable tool for managing lower extremity conditions.

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