Anti-inflammatory and wound healing activity of a growth substance in Aloe vera

RH DavisDepartment of Biomedical Sciences, Pennsylvania College of Podiatric Medicine, Philadelphia.

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JJ DonatoDepartment of Biomedical Sciences, Pennsylvania College of Podiatric Medicine, Philadelphia.

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GM HartmanDepartment of Biomedical Sciences, Pennsylvania College of Podiatric Medicine, Philadelphia.

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RC HaasDepartment of Biomedical Sciences, Pennsylvania College of Podiatric Medicine, Philadelphia.

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Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.