Lower extremity macrovascular disease in diabetes

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  • 1 Beth Israel Medical Center, Harvard Medical School, Boston, MA, USA.
  • | 2 Beth Israel Medical Center, Harvard Medical School, Boston, MA, USA.
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Lower extremity macrovascular disease is more common and progresses more rapidly in the presence of diabetes and has a characteristic peritibial distribution with sparing of the foot arteries. The biology of the diabetic foot is compromised, thereby making it more susceptible to injury. Hence, compromises in perfusion have a greater significance, warranting an aggressive approach to revascularization.