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Sixteen subjects with hemophilia A of levels 1–5 stage of joint damage were tested over a 6-week period to evaluate the efficacy of functional foot orthoses. The level of ankle bleeds (hemarthrosis) before and after the intervention with functional foot orthoses was determined by evaluating pain, disability, and activity levels. All subjects reported a significant reduction of ankle bleeds coinciding with the intervention of functional foot orthoses. The use of a foot-pain disability measure clearly showed significant reduction in the level of pain experienced by the subjects and in their overall index score. However, the disability and activity index scores showed no significant improvement after the intervention with orthoses. This finding would support the use of functional foot orthoses to treat patients with hemophilia A, as significant reduction in pain levels appears to greatly improve the lives of the patients. (J Am Podiatr Med Assoc 91(5): 240-244, 2001)