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Wound Treatment with Human Skin Equivalent

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  • 1 Submitted during second year, University of Michigan Medical School, Ann Arbor, MI.
  • | 2 Assistant Professor, Department of Surgery, Mount Sinai Medical Center, New York, NY.
  • | 3 Professor and Vice Chairman, Department of Surgery, Mount Sinai Medical Center, New York, NY. Mailing address: 1214 Valley Rd, Villanova, PA 19085-2124.
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Skin grafting provides an effective means of closing chronic wounds. Autografts and allografts are used most often in skin grafting, but Apligraf, a tissue-engineered bilayered human skin equivalent, provides another safe and effective grafting option for treating diabetic, venous, and pressure ulcers. This skin equivalent has an epidermis and dermis similar to human skin, largely due to its derivation from neonatal foreskin. Apligraf is also easily accessible and has shown little immunoreactivity. (J Am Podiatr Med Assoc 92(1): 19-23, 2002)