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Cellular Senescence and Matrix Metalloproteinase Activity in Chronic Wounds

Relevance to Debridement and New Technologies

Gerit D. Mulder Director of Research and Education, Clinical Director, University of California San Diego Medical Center, Regional Burn Center/Wound Treatment and Research Center, 200 W Arbor Dr 8896, San Diego, CA 92103-8896.

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Jerry S. Vande Berg Director, Core Clinical and Research Imaging Facility, Research Service V-151, Veterans Administration Medical Center, San Diego, CA.

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A prolonged inflammatory response may adversely affect wound closure. Delayed wound closure and extended exposure to chronic wound fluid may also affect cellular activity in a wound bed and result in cellular senescence. Prolonged inflammation and cellular senescence may adversely affect the efficacy of topically-applied biological agents, including growth factors. Appropriate wound bed preparation and debridement are necessary to improve clinical outcomes of new technologies.(J Am Podiatr Med Assoc 92(1): 34-37, 2002)