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    2000 Physicians’ Desk Reference. Medical Economics, Montvale, NJ, 2000..

A Comparative Study of Lactic Acid 10% and Ammonium Lactate 12% Lotion in the Treatment of Foot Xerosis

Maureen B. Jennings Assistant Dean for Research; Professor of Medicine, New York College of Podiatric Medicine. Mailing address: 1800 Park Ave, New York, NY 10035.

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Loretta Logan Assistant Professor of Orthopedics, New York College of Podiatric Medicine.

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Donna M. Alfieri Assistant Professor of Medicine, New York College of Podiatric Medicine.

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Charles F. Ross Assistant Dean for Student Affairs and Admissions; Clinical Associate Professor of Medicine, New York College of Podiatric Medicine.

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Susan Goodwin Assistant Professor, Department of Health Quantitative Sciences, New York Medical College, Valhalla, NY.

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Christine Lesczczynski Clinical Research Associate, New York College of Podiatric Medicine.

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Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common. This double-blind, randomized clinical trial investigated the effect of Lactinol (Pedinol Pharmaceuticals, Farmingdale, New York) versus Lac-Hydrin 12% (Bristol-Myers Squibb, Princeton, New Jersey) lotion in mild to moderate foot xerosis. Clinical assessment of xerosis was performed at baseline visit, and the designated sites were evaluated at 2 and 4 weeks after treatment began. Of the 53 patients enrolled, 18 were excluded from analysis. Although both treatment groups had significantly improved xerosis scores after 2 and 4 weeks of treatment, no statistically significant difference was observed. Of the 44% of patients who did express a preference, 72% preferred Lactinol, which may account for the 20% increase in its overall use in the study. (J Am Podiatr Med Assoc 92(3): 143-148, 2002)