• 1

    Veves A, Falanga V, Armstrong DG, et al: Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial. .Diabetes Care 24::290. ,2001. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Gentzkow GD, Iwasaki SD, Hershon KS, et al: Use of Dermagraft, a cultured human dermis, to treat diabetic foot ulcers. .Diabetes Care 19::350. ,1996. .

  • 3

    Armstrong DG, Lavery LA, Abu Rumman PL, et al: Outcomes of topical vacuum on wounds of the diabetic foot. .Ostomy Wound Manage 48::64. ,2002. .

  • 4

    Schneider AM, Morykwas MJ, Argenta LC: A new and reliable method of securing skin grafts to the difficult recipient bed. .Plast Reconstr Surg 102::1195. ,1998. .

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5

    Genecov DG, Schneider AM, Morykwas MJ, et al: A controlled subatmospheric pressure dressing increases the rate of skin graft donor site reepithelialization. .Ann Plast Surg 40::219. ,1998. .

    • PubMed
    • Search Google Scholar
    • Export Citation

Use of Subatmospheric (VAC) Therapy to Improve Bioengineered Tissue Grafting in Diabetic Foot Wounds

Eric H. Espensen Attending Physician, Diabetic Foot Center, Providence St Joseph Medical Center, Burbank, CA.

Search for other papers by Eric H. Espensen in
Current site
Google Scholar
PubMed
Close
 DPM
,
Brent P. Nixon Chief, Department of Surgery, Podiatry Section, Southern Arizona Veterans Affairs Medical Center, Tucson.

Search for other papers by Brent P. Nixon in
Current site
Google Scholar
PubMed
Close
 DPM
,
Lawrence A. Lavery Associate Professor, Department of Orthopaedics, Loyola University, Chicago, IL.

Search for other papers by Lawrence A. Lavery in
Current site
Google Scholar
PubMed
Close
 DPM, MPH
, and
David G. Armstrong Director of Research and Education, Department of Surgery, Podiatry Section, Southern Arizona Veterans Affairs Medical Center, Tucson; Visiting Senior Lecturer of Medicine, Department of Medicine, Manchester Royal Infirmary, Manchester, England. Mailing address:Department of Surgery, Podiatry Section, Southern Arizona Veterans Affairs Medical Center, 3601 S Sixth Ave, Tucson, AZ 85723.

Search for other papers by David G. Armstrong in
Current site
Google Scholar
PubMed
Close
 DPM

The use of bioengineered tissue and topical subatmospheric pressure therapy have both been widely accepted as adjunctive therapies for the treatment of noninfected, nonischemic diabetic foot wounds. This article describes a temporally overlapping method of care that includes a period of simultaneous application of bioengineered tissue (Apligraf, Novartis Pharmaceuticals Corp, East Hanover, New Jersey) and subatmospheric pressure therapy delivered through the VAC (Vacuum Assisted Closure) system (KCI, Inc, San Antonio, Texas). Future descriptive and analytic works may test the hypothesis that combined therapies used at different and often overlapping periods during the wound-healing cycle may be more effective than a single modality. (J Am Podiatr Med Assoc 92(7): 395-397, 2002)

Save