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Satisfaction with Onychomycosis Treatment

Pulse versus Continuous Dosing

Erin M. Warshaw Minneapolis Veterans Affairs Medical Center, Minneapolis, MN.

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Thomas Bowman North Oaks Podiatry, Dalton, GA.

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Myron A. Bodman Ohio College of Podiatric Medicine, Cleveland.

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John J. Kim Duke University, Durham, NC. Dr. Kim is now with Amgen Inc, Thousand Oaks, CA.

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Stefanie Silva Quintiles Late Phase, San Francisco, CA. Ms. Mathias is now with Ovation Research Group, Highland Park, IL.

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Susan D. Mathias Quintiles Late Phase, San Francisco, CA. Ms. Mathias is now with Ovation Research Group, Highland Park, IL.

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The purpose of this study, which involved two dermatology clinics and two podiatric medical clinics, was to determine whether a difference exists in patient-reported satisfaction and compliance between continuous terbinafine therapy and pulse-dose itraconazole therapy for the treatment of toenail onychomycosis. Patients in this multicenter, open-label, cross-sectional study had previously completed treatment with either oral terbinafine or oral itraconazole for toenail onychomycosis. Patients were interviewed by telephone to assess clinical outcomes, compliance, and satisfaction with treatment; clinical data were collected by medical chart review. Patients reported significantly greater ease and convenience of treatment and higher overall satisfaction with continuous terbinafine therapy compared with pulse-dose itraconazole therapy. (J Am Podiatr Med Assoc 93(5): 373-379, 2003)

Corresponding author: Erin M. Warshaw, MD, Minneapolis Veterans Affairs Medical Center, Dermatology/IIIK, One Veterans Dr, Minneapolis, MN 55417.