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Diseases of the liver and abnormalities of liver enzyme levels are among the most common reasons for gastroenterology consultation for surgical patients. Although the differential diagnosis of liver disease is exceedingly broad, the majority of patients will have one of several common disorders. A familiarity with the major disorders affecting the liver and the approach to patients with liver disease is therefore useful for clinicians from all disciplines. This article reviews common liver diseases, including the viral hepatitides; the interpretation of liver enzyme abnormalities; and the relationship between common medications and liver disease. Although an exhaustive knowledge of hepatology is impractical for most clinicians, a practical approach to common liver diseases is a necessity for all. (J Am Podiatr Med Assoc 94(2): 149-156, 2004)