• Chapman D, Thomlinson W, Johnston RE, Washburn D, Pisano E, Gmur N, et al. (. 1997. ) Diffraction enhanced X-ray imaging.Phys. Med. Biol. 42:,2015.–2025.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Chapman LD, Pisano E, Thomlinson W, Zhong Z, Johnston RE, Washburn D, et al. (. 1998. ) Medical application of diffraction enhanced imaging.Breast Dis. 10:,197.–207.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Dieppe P, Cushnaghan J, McAlindon T (. 1992. ) Epidemiology, clinical course, and outcome of knee osteoarthritis. In Articular Cartilage and Osteoarthritis (eds Kuettner KE, Schleyerbach R, Peyron JG, Hascall VC), pp. 617–628. New York: Raven Press.

  • Mollenhauer JA, Aurich ME, Zhong Z, Muehleman C, Cole AA, Hasnah M, et al. (. 2002. ) Diffraction-enhanced X-ray imaging of articular cartilage.Osteoarthritis Cartilage 10:,163.–171.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Muehleman C, Zhong Z, Williams JM, Kuettner KE, Aurich M, Han B, Mollenhauer J (. 2002. ) Diffraction enhanced X-ray imaging of the articular cartilage of experimental animals. Proceedings of the Ann. Mtg. Orthop. Res. Soc., p. 365.

  • Peterfy C (. 1997. ) Imaging techniques. In Rheumatology (eds Klippel J, Dieppe P), Vol. 1, p14.1–14.48. Philadelphia: Mosby.

  • Staren C (. 1980. ) The soft tissues. In A Textbook of Radiology, 3rd edn (ed. Sutton D), pp. 1025–1048. New York: Churchill Livingstone.

  • Zachariasen WH (. 1945. ) Theory of X-Ray Diffraction in Crystals. New York: John Wiley and Sons.

  • Zhong Z (. 2000. ) Using a prism to reject or select harmonic reflections in an X-ray monochromator.J. Appl. Cryst. 33:,1082.–1087.

  • Zhong Z, Thomlinson W, Chapman D, Sayers D (. 2000. ) Implementation of diffraction enhanced imaging experiments: at the NSLS and ASP.Nucl. Instrum. Meth. Phys. Res. 450:,556.–568.

    • Search Google Scholar
    • Export Citation

Radiography of Soft Tissue of the Foot and Ankle with Diffraction Enhanced Imaging

Jun Li Department of Biochemistry, Rush Medical College, Chicago, IL.

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Zhong Zhong National Synchrotron Light Source, Brookhaven National Laboratory, Upton, NY.

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Roy Lidtke Dr. William M. Scholl College of Podiatric Medicine at Finch University and Chicago Medical School, North Chicago, IL.

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Klaus E. Kuettner Department of Biochemistry, Rush Medical College, Chicago, IL.

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Charles Peterfy SYNARC, Inc, San Francisco, CA.

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Elmira Aliyeva Department of Biochemistry, Rush Medical College, Chicago, IL.

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Carol Muehleman Departments of Biochemistry and Anatomy, Rush Medical College, Chicago, IL.

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Non-calcified tissues, including tendons, ligaments, adipose tissue and cartilage, are not visible, for any practical purposes, with conventional X-ray imaging. Therefore, any pathological changes in these tissues generally necessitate detection through magnetic resonance imaging or ultrasound technology. Until recently the development of an X-ray imaging technique that could detect both bone and soft tissues seemed unrealistic. However, the introduction of diffraction enhanced X-ray imaging (DEI) which is capable of rendering images with absorption, refraction and scatter rejection qualities has allowed detection of specific soft tissues based on small differences in tissue densities. Here we show for the first time that DEI allows high contrast imaging of soft tissues, including ligaments, tendons and adipose tissue, of the human foot and ankle. (J Am Podiatr Med Assoc 94(3): 315–322, 2004)

Corresponding author: Carol Muehleman, PhD, Department of Anatomy, Rush Medical College, ACFAC507, 600 S Paulina, Chicago, IL 60612.