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-
1
Associated Press: 103,000 die from hospital infections, Daytona News Journal, July 22. ,2002. , p 1A.
-
2
Garibaldi RA, Skolnick D, Lerer T, et al: The impact of preoperative skin disinfection on preventing intraoperative wound contamination. .Infect Control Hosp Epidemiol 9::109. ,1988. .
-
3
Simon B: “Treatment of Wounds,” in Emergency Medicine: Concepts and Clinical Practice, 2nd Ed, ed by P Rosen et al, p 363, CV Mosby, St Louis. ,1988. .
-
4
Holmes JD: Classification of wounds and their management. .Surgery 17::63. ,1999. .
-
5
White RJ, Cooper R, Kingsley A: Wound colonization and infection: the role of topical antimicrobials. .Br J Nurs 10::563. ,2001. .
-
6
Dearden C, Donnell J, Donnelly J, et al: Traumatic wounds: cleansing and dressing. .Nurs Times 97::50. ,2001. .
-
7
Lawrence JC: Wound irrigation: an update of irrigating fluids and their effects on wounds. .J Wound Care 6::23. ,1997. .
-
8
Forrest RD: Early history of wound treatment. .J R Soc Med 75::198. ,1982. .
-
9
Caldwell MD: Topical wound therapy: an historical perspective. .J Trauma 30::S116. ,1990. .
-
10
Ryan KJ: “Sterilization, Pasteurization, and Disinfection,” in Sherris Medical Microbiology: An Introduction to Infectious Diseases, 3rd Ed, p 171, Appleton & Lange, Norwalk, CT. ,1994. .
-
11
Cooper R, Lawrence JC: The role of antimicrobial agents in wound care. .J Wound Care 5::374. ,1996. .
-
12
Russell AD: Mechanisms of antimicrobial action of antiseptics and disinfectants: an increasingly important area of investigation. .J Antimicrob Chemother 49::597. ,2002. .
-
13
Morison MJ: Wound cleansing: which solution?. Prof Nurs 4::220. ,1989. .
-
14
Leaper D: Antiseptics in wound healing. .Nurs Times 92::63. ,1996. .
-
15
Fleming A: The action of chemical and physiological antiseptics in a septic wound: Hunterian Lecture. .Br J Surg 7::99. ,1991. .
-
16
Brennan S, Leaper D: The effects of antiseptics on the healing wound: a study using the rabbit ear chamber. .Br J Surg 72::780. ,1985. .
-
17
Sussman G: “Management of the Wound Environment,” in Wound Care: A Collaborative Practice Manual for Physical Therapists and Nurses, ed by C Sussman, BM Bates-Jensen, p 201, Aspen Publishers, Gaithersburg, MD. ,1998. .
-
18
Rodeheaver G: Controversies in topical wound management. .Wounds Compend Clin Res Pract 1::19. ,1989. .
-
19
Rodeheaver GT, Pettry D, Thacker JG, et al: Wound cleansing by high pressure irrigation. .Surg Gynecol Obstet 141::357. ,1975. .
-
20
Whittington K: Debunking wound care myths. .RN 58::32. ,1995. .
-
21
Bergstrom N: Treatment of Pressure Ulcers: Clinical Practice Guidelines, AHCPR publication 95-0652, p 50, US Department of Health and Human Services, Rockville, MD. ,1994. .
-
22
Mertz PM, Alvarez OM, Smerbeck RV, et al: A new in vivo model for the evaluation of topical antiseptics on superficial wounds. .Arch Dermatol 120::58. ,1984. .
-
23
Gruber RP, Vistnes L, Pardoe R: The effect of commonly used antiseptics on wound healing. .Plast Reconstr Surg 55::472. ,1975. .
-
24
Cotter JL, Fader RC, Lilley C, et al: Chemical parameters, antimicrobial activities, and tissue toxicity of 0.1 and 0.5% sodium hypochlorite solutions. .Antimicrob Agents Chemother 28::118. ,1985. .
-
25
Lineaweaver W, Howard R, Soucy D, et al: Topical antimicrobial toxicity. .Arch Surg 120::267. ,1985. .
-
26
Lineaweaver W, McMorris S, Soucy D, et al: Cellular and bacterial toxicities of topical antimicrobials. .Plast Reconstr Surg 75::394. ,1985. .
-
27
Kozol RA, Gillies C, Elgebaly SA: Effects of sodium hypochlorite (Dakin’s solution) on cells of the wound module. .Arch Surg 123::420. ,1988. .
-
28
Heggers JP, Sazy JA, Stenberg BD, et al: Bactericidal and wound-healing properties of sodium hypochlorite solutions: the 1991 Lindberg Award. .J Burn Care Rehabil 12::420. ,1991. .
-
29
Cooper ML, Laxer JA, Hansbrough JF: The cytotoxic effects of commonly used topical antimicrobial agents on human fibroblasts and keratinocytes. .J Trauma 31::775. ,1991. .
-
30
Smoot EC, Kucan JO, Roth A, et al: In vitro toxicity testing for antibacterials against human keratinocytes. .Plast Reconstr Surg 87::917. ,1991. .
-
31
Falanga V, Zitelli JA, Eaglstein WH: Wound healing. .J Am Acad Dermatol 19::559. ,1988. .
-
32
Singer AJ, Clark RAF: Cutaneous wound healing. .N Engl J Med 341::738. ,1999. .
-
33
Redmond AC, Keenan AM, Landorf K: “Horses for courses”: the differences between quantitative and qualitative approaches to research. .JAPMA 92::159. ,2002. .
-
34
Kirsner RS, Katz MH, Eaglstein WH, et al: The biology of wound fluid. .Wounds 5::122. ,1993. .
-
35
Viljanto J, Vilkki P: “The Effect of Betadine Airsol Spray on Wound Healing in Abdominal Incisions,” in Proceedings of the First Asian/Pacific Congress on Antisepsis, ed by S Selwyn, Royal Society of Medicine Services, London. ,1988. .
-
36
Mayer DA, Tsapogas MJ: Povidone-iodine and wound healing: a critical review. .Wounds 5::14. ,1993. .
-
37
Howard R: The appropriate use of topical antimicrobials and antiseptics in children. .Pediatr Ann 30::219. ,2001. .
-
38
Pascher F: Systemic reactions to topically applied drugs. .Int J Dermatol 17::768. ,1975. .
-
39
Spray A, Siegfried E: Dermatologic toxicology in children. .Pediatr Ann 30::197. ,2001. .
-
40
McAllister TA, Lucas CE, Mocan H, et al: Serratia marcescens outbreak in a paediatric oncology unit traced to contaminated chlorhexidine. .Scott Med J 34::525. ,1989. .
-
41
Schneider DL, Hebert LJ: Subcutaneous gas from hydrogen peroxide administration under pressure. .Am J Dis Child 141::10. ,1987. .
-
42
Saissy JM, Guignard B, Pats B, et al: Pulmonary edema after hydrogen peroxide irrigation of a war wound. .Intens Care Med 21::287. ,1995. .
-
43
Shetty KR, Duthie EH: Thyrotoxicosis induced by topical iodine application. .Arch Intern Med 150::2400. ,1990. .
-
44
Gordon CM, Rowitch DH, Mitchell ML, et al: Topical iodine and neonatal hypothyroidism. .Arch Pediatr Adolesc Med 149::1336. ,1995. .
-
45
Brown RS, Bloomfield S, Bednarek FJ, et al: Routine skin cleansing with povidone-iodine is not a common cause of transient neonatal hypothyroidism in North America: a prospective controlled study. .Thyroid 7::395. ,1997. .
-
46
Kanj LF, Phillips TJ: Skin problems in the elderly. .Wounds 13::93. ,2001. .
-
47
Niedner R: Cytotoxicity and sensitization of povidone-iodine and other frequently used anti-infective agents. .Dermatology 195: (suppl 2):89. ,1997. .
-
48
The Purdue Frederick Company: “Betadine Solution,” in Physicians’ Desk Reference, 58th Ed, p 2839, Thomson PDR, Montvale, NJ. ,2004. .
-
49
Andrews LW: The perils of povidone-iodine use. .Ostomy Wound Manage 40::68. ,1994. .
-
50
Rodeheaver GT: Conflicting points of view regarding the use of povidone iodine. .Ostomy Wound Manage 40::6. ,1994. .
-
51
Mayer DA: Conflicting points of view regarding the use of povidone-iodine. .Ostomy Wound Manage 40::6. ,1994. .
-
52
Welch JS: The perils of povidone-iodine use re-examined. .Ostomy Wound Manage 40::6. ,1994. .
-
53
Welch JS: Efficacy and safety of povidone-iodine underscored. .J Emerg Nurs 18::191. ,1992. .
-
54
Howell JM, Chisholm CD: Outpatient wound preparation and care: a national survey. .Ann Emerg Med 21::976. ,1992. .
-
55
Mertz PM, Davis S, Brewer L, et al: Can antimicrobials be effective without impairing wound healing? the evaluation of cadexomer iodine ointment. .Wounds 6::184. ,1994. .
-
56
Singer AJ, Hollander JE, Quinn JV: Evaluation and management of traumatic lacerations. .N Engl J Med 337::1142. ,1997. .
-
57
Dire DJ, Welsh AP: A comparison of wound irrigation solutions used in the emergency department. .Ann Emerg Med 19::704. ,1990. .
-
58
Gouin S, Patel H: Office management of minor wounds. .Can Fam Physician 47::769. ,2001. .
-
59
Margolis DJ, Berlin JA, Strom BL: Interobserver agreement, sensitivity and specificity of a healed chronic wound. .Wound Repair Regen 4::335. ,1996. .
-
60
Siwek J, Gourlay ML, Slawson DC, et al: How to write an evidence-based clinical review article. .Am Fam Physician 65::251. ,2002. .
A Critical Discussion of the Use of Antiseptics in Acute Traumatic Wounds
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Approximately 10 million patients with traumatic wounds are treated in US emergency departments annually. The practice of wound cleansing or antiseptic management has a dichotomous history anchored in tradition and science. The merits of antiseptic fluid irrigation of traumatic wounds have received little scientific study. The purpose of this article is to critically evaluate the potential harm to patient outcome by the use of antiseptics on acute wounds. First, animal and cell culture data that describe the effects of topical antiseptics on wound healing are offered. Second, human case studies are presented to illustrate the potential harm of the indiscriminate use of antiseptics. Finally, data from previously published reviews are presented and evaluated for clinically based evidence to justify the current practice of antiseptic use in acute traumatic wounds. (J Am Podiatr Med Assoc 95(2): 148–153, 2005)
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