• 1

    Lipsky BA. A report from the international consensus on diagnosing and treating the infected diabetic foot. .Diabetes Metab Res Rev 2004. ;20:(Suppl 1):S68.–77.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Jeffcoate WJ, Harding KG. Diabetic foot ulcers. .Lancet 2003. ;361::1545.–51.

  • 3

    Tennvall GR, Apelqvist J, Eneroth M. Costs of deep foot infections in patients with diabetes mellitus. .Pharmacoeconomics 2000. ;18::225.–38.

  • 4

    Ramsey SD, Newton K, Blough D, et al. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. .Diabetes Care 1999. ;22::382.–7.

  • 5

    Reiber GE. The epidemiology of diabetic foot problems. .Diabet Med 1996. ;13:(Suppl 1):S6.–11.

  • 6

    Reiber GE, Vileikyte L, Boyko EJ, et al. Causal pathways for incident lower-extremity ulcers in patients with diabetes from two settings. .Diabetes Care 1999. ;22::157.–62.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Pecoraro RE, Reiber GE, Burgess EM. Pathways to diabetic limb amputation: basis for prevention. .Diabetes Care 1990. ;13::513.–21.

  • 8

    Crane M, Werber B. Critical pathway approach to diabetic pedal infections in a multidisciplinary setting. .J Foot Ankle Surg 1999. ;38::30.–3; discussion 82–3.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9

    Todd WF, Armstrong DG, Liswood PJ. Evaluation and treatment of the infected foot in a community teaching hospital. .J Am Podiatr Med Assoc 1996. ;86::421.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10

    Dargis V, Pantelejeva O, Jonushaite A, Vileikyte L, Boulton AJ. Benefits of a multidisciplinary approach in the management of recurrent diabetic foot ulceration in Lithuania: a prospective study. .Diabetes Care 1999. ;22::1428.–31.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11

    Schaper NC, Apelqvist J, Bakker K. The international consensus and practical guidelines on the management and prevention of the diabetic foot. .Curr Diab Rep 2003. ;3::475.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Ragnarson Tennvall G, Apelqvist J. Prevention of diabetes-related foot ulcers and amputations: a cost-utility analysis based on Markov model simulations. .Diabetologia 2001. ;44::2077.–87.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Armstrong DG, Harkless LB. Outcomes of preventative care in a diabetic foot specialty clinic. .J Foot Ankle Surg 1998. ;37::460.–6.

  • 14

    Armstrong DG, Liswood PJ, Todd WF. Prevalence of mixed infections in the diabetic pedal wound: a retrospective review of 112 infections. 1995 William J. Stickel bronze award. .J Am Podiatr Med Assoc 1995. ;85::533.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15

    Calhoun JH, Cantrell J, Cobos J, et al. Treatment of diabetic foot infections: Wagner classification, therapy, and outcome. .Foot Ankle 1988. ;9::101.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16

    Edelson GW, Armstrong DG, Lavery LA, Caicco G. The acutely infected diabetic foot is not adequately evaluated in an inpatient setting. .Arch Intern Med 1996. ;156::2373.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17

    American Diabetes Association. Consensus development conference on diabetic foot wound care: 7–8 April 1999, Boston, Massachusetts. .Diabetes Care 1999. ;22::1354.–60.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18

    Frykberg RG, Armstrong DG, Giurini J, et al. Diabetic foot disorders: a clinical practice guideline. American College of Foot and Ankle Surgeons. .J Foot Ankle Surg 2000. ;39::S1.–60.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19

    Pinzur MS, Slovenkai MP, Trepman E. Guidelines for diabetic foot care. The Diabetes Committee of the American Orthopaedic Foot and Ankle Society. .Foot Ankle Int 1999. ;20::695.–702.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20

    Lutter LD. Sooner beats the cost of later [editorial]. .Foot Ankle Int 1995. :387..

  • 21

    Armstrong DG. Is diabetic foot care efficacious or cost effective?. Ostomy Wound Manage 2001. ;47::28.–32.

  • 22

    Piwernetz K, Home PD, Snorgaard O, Antsiferov M, Staehr-Johansen K, Krans M. Monitoring the targets of the St. Vincent Declaration and the implementation of quality management in diabetes care: the DIABCARE initiative. The DIABCARE Monitoring Group of the St. Vincent Declaration Steering Committee. .Diabet Med 1993. ;10::371.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 23

    International Working Group on the Diabetic Foot. International consensus on the diabetic foot [CD-ROM]. Brussels: International Diabetes Foundation, May. 2003. .

    • PubMed
    • Export Citation
  • 24

    Kish MA. Guide to development of practice guidelines. .Clin Infect Dis 2001. ;32::851.–4.

  • 25

    Caputo GM, Cavanagh PR, Ulbrecht JS, Gibbons GW, Karchmer AW. Assessment and management of foot disease in patients with diabetes. .N Engl J Med 1994. ;331::854.–60.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26

    Frykberg RG. Diabetic foot ulcers: current concepts. .J Foot Ankle Surg 1998. ;37::440.–6.

  • 27

    Schubert S, Heesemann J. Infections in diabetes mellitus [in German]. .Immun Infekt 1995. ;23::200.–4.

  • 28

    Gin H. Infection and diabetes [in French]. .Rev Med Interne 1993. ;14::32.–8.

  • 29

    Joshi N, Caputo G, Weitekamp M, Karchmer A. Infections in patients with diabetes mellitus. .N Engl J Med 1999. ;341::1906.–12.

  • 30

    Geerlings SE, Hoepelman AIM. Immune dysfunction in patients with diabetes mellitus (DM). .FEMS Immunology and Medical Microbiology 1999. ;26::259.–65.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 31

    Lipsky BA, Pecoraro RE, Wheat LJ. The diabetic foot: soft tissue and bone infection. .Infect Dis Clin North Am 1990. ;4::409.–32.

  • 32

    Grayson ML. Diabetic foot infections: antimicrobial therapy. .Infect Dis Clin North Am 1995. ;9::143.–61.

  • 33

    Joseph WS, Axler DA. Microbiology and antimicrobial therapy of diabetic foot infections. .Clin Podiatr Med Surg 1990. ;7::467.–81.

  • 34

    Goldstein EJ, Citron DM, Nesbit CA. Diabetic foot infections: bacteriology and activity of 10 oral antimicrobial agents against bacteria isolated from consecutive cases. .Diabetes Care 1996. ;19::638.–41.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 35

    El-Tahawy AT. Bacteriology of diabetic foot. .Saudi Med J 2000. ;21::344.–7.

  • 36

    Urbancic-Rovan V, Gubina M. Bacteria in superficial diabetic foot ulcers. .Diabet Med 2000. ;17::814.–5.

  • 37

    Sims D, Keating SE, DeVincentis AF. Bacteriology of diabetic foot ulcers. .J Foot Surg 1984. ;23::149.–51.

  • 38

    Jones EW, Edwards R, Finch R, Jeffcoate WJ. A microbiological study of diabetic foot lesions. .Diabet Med 1985. ;2::213.–5.

  • 39

    Gerding DN. Foot infections in diabetic patients: the role of anaerobes. .Clin Infect Dis 1995. ;20:(Suppl 2):S283.–8.

  • 40

    Pathare NA, Bal A, Talvalkar GV, Antani DU. Diabetic foot infections: a study of microorganisms associated with the different Wagner grades. .Indian J Pathol Microbiol 1998. ;41::437.–41.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 41

    Sapico FL, Witte JL, Canawati HN, Montgomerie JZ, Bessman AN. The infected foot of the diabetic patient: quantitative microbiology and analysis of clinical features. .Rev Infect Dis 1984. ;6:(Suppl 1):S171.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 42

    Wheat LJ, Allen SD, Henry M, et al. Diabetic foot infections: bacteriologic analysis. .Arch Intern Med 1986. ;146::1935.–40.

  • 43

    Hunt JA. Foot infections in diabetes are rarely due to a single microorganism. .Diabet Med 1992. ;9::749.–52.

  • 44

    Hartemann-Heurtier A, Robert J, Jacqueminet S, et al. Diabetic foot ulcer and multidrug-resistant organisms: risk factors and impact. .Diabet Med 2004. ;21::710.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 45

    Eady EA, Cove JH. Staphylococcal resistance revisited: community-acquired methicillin-resistant Staphylococcus aureus—an emerging problem for the management of skin and soft tissue infections. .Curr Opin Infect Dis 2003. ;16::103.–24.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 46

    Wagner A, Reike H, Angelkort B. Highly resistant pathogens in patients with diabetic foot syndrome with special reference to methicillin-resistant Staphylococcus aureus infections [in German]. .Dtsch Med Wochenschr 2001. ;126::1353.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 47

    Dang C, Prasad Y, Bouton A, Jude EB. Methicillin-resistant Staphylococcus aureus in the diabetic foot clinic: a worsening problem. .Diabet Med 2003. ;20::159.–61.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 48

    Tentolouris N, Jude EB, Smirnof I, Knowles EA, Boulton AJ. Methicillin-resistant Staphylococcus aureus: an increasing problem in a diabetic foot clinic. .Diabet Med 1999. ;16::767.–71.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 49

    Centers for Disease Control and Prevention. Vancomycin-resistant Staphylococcus aureus—Pennsylvania, 2002. .MMWR Morb Mortal Wkly Rep 2002. ;51::902..

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 50

    Bessman AN, Geiger PJ, Canawati H. Prevalence of Corynebacteria in diabetic foot infections. .Diabetes Care 1992. ;15::1531.–3.

  • 51

    Ge Y, MacDonald D, Hait H, Lipsky B, Zasloff M, Holroyd K. Microbiological profile of infected diabetic foot ulcers. .Diabet Med 2002. ;19::1032.–4.

  • 52

    Sapico FL, Canawati HN, Witte JL, Montgomerie JZ, Wagner FW Jr., Bessman AN. Quantitative aerobic and anaerobic bacteriology of infected diabetic feet. .J Clin Microbiol 1980. ;12::413.–20.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 53

    Axler DA. Microbiology of diabetic foot infections. .J Foot Surg 1987. ;26::S3.–6.

  • 54

    Bowler PG, Duerden BI, Armstrong DG. Wound microbiology and associated approaches to wound management. .Clin Microbiol Rev 2001. ;14::244.–69.

  • 55

    Sharp CS, Bessmen AN, Wagner FW Jr., Garland D, Reece E. Microbiology of superficial and deep tissues in infected diabetic gangrene. .Surg Gynecol Obstet 1979. ;149::217.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 56

    Bessman AN, Sapico FL, Tabatabai M, Montgomerie JZ. Persistence of polymicrobial abscesses in the poorly controlled diabetic host. .Diabetes 1986. ;35::448.–53.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 57

    Borrero E, Rossini M Jr. Bacteriology of 100 consecutive diabetic foot infections and in vitro susceptibility to ampicillin/sulbactam versus cefoxitin. .Angiology 1992. ;43::357.–61.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 58

    Viswanathan V, Jasmine JJ, Snehalatha C, Ramachandran A. Prevalence of pathogens in diabetic foot infection in South Indian type 2 diabetic patients. .J Assoc Physicians India 2002. ;50::1013.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 59

    American Diabetes Association. Peripheral arterial disease in people with diabetes. .Diabetes Care 2003. ;26::3333.–41.

  • 60

    Boyko EJ, Ahroni JH, Davignon D, Stensel V, Prigeon RL, Smith DG. Diagnostic utility of the history and physical examination for peripheral vascular disease among patients with diabetes mellitus. .J Clin Epidemiol 1997. ;50::659.–68.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 61

    Apelqvist J, Larsson J, Agardh CD. The importance of peripheral pulses, peripheral oedema, and local pain for the outcome of diabetic foot ulcers. .Diabet Med 1990. ;7::590.–4.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 62

    McGee SR, Boyko EJ. Physical examination and chronic lower-extremity ischemia: a critical review. .Arch Intern Med 1998. ;158::1357.–64.

  • 63

    Faglia E, Favales F, Quarantiello A, et al. Angiographic evaluation of peripheral arterial occlusive disease and its role as a prognostic determinant for major amputation in diabetic subjects with foot ulcers. .Diabetes Care 1998. ;21::625.–30.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 64

    Apelqvist J, Castenfors J, Larsson J, Stenstrom A, Agardh CD. Prognostic value of systolic ankle and toe blood pressure levels in outcome of diabetic foot ulcer. .Diabetes Care 1989. ;12::373.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 65

    Emanuele MA, Buchanan BJ, Abraira C. Elevated leg systolic pressures and arterial calcification on diabetic occlusive vascular disease. .Diabetes Care 1981. ;4::289.–92.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 66

    Windsor T. Influence of arterial disease on the systolic blood pressure gradients of the extremity. .Am J Med Sci 1950. ;220::117.–26.

  • 67

    Carter SA. Clinical measurement of systolic pressures in limbs with arterial occlusive disease. .JAMA 1969. ;207::1869.–74.

  • 68

    LoGerfo FW, Coffman JD. Current concepts: vascular and microvascular disease of the foot in diabetes: implication for foot care. .N Engl J Med 1984. ;311::1615.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 69

    LoGerfo FW, Gibbons GW. Ischemia in the diabetic foot: modern concepts and management. .Clinical Diabetes July/Aug 1989. :72.–5.

  • 70

    Boyko EJ, Ahroni JH, Stensel VL, Smith DG, Davignon DR, Pecoraro RE. Predictors of transcutaneous oxygen tension in the lower limbs of diabetic subjects. .Diabet Med 1996. ;13::549.–54.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 71

    Kalani M, Brismar K, Fagrell B, Ostergren J, Jorneskog G. Transcutaneous oxygen tension and toe blood pressure as predictors of outcome of diabetic foot ulcers. .Diabetes Care 1999. ;22::147.–51.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 72

    Matsen FA 3rd, Wyss CR, Pedegana LR, et al. Transcutaneous oxygen tension measurement in peripheral vascular disease. .Surg Gynecol Obstet 1980. ;150::525.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 73

    Christensen KS, Klark M. Transcutaneous oxygen measurement in peripheral occlusive disease: an indicator of wound healing in leg amputation. .J Bone Joint Surg 1986. ;68::423.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 74

    Wyss CR, Robertson C, Love SJ, Harrington RM, Matsen FA 3rd. Relationship between transcutaneous oxygen tension, ankle blood pressure, and clinical outcome of vascular surgery in diabetic and nondiabetic patients. .Surgery 1987. ;101::56.–62.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 75

    Sheffield PJ. Measuring tissue oxygen tension: a review. .Undersea Hyperb Med 1988. ;25::179.–88.

  • 76

    Gaylarde PM, Fonseca VA, Llewellyn G, Sarkany I, Thomas PK, Dandona P. Transcutaneous oxygen tension in legs and feet of diabetic patients. .Diabetes 1988. ;37::714.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 77

    Sosenko JM, Kato M, Soto R, Build DE. Comparison of quantitative sensory-threshold measures for their association with foot ulceration in diabetic patients. .Diabetes Care 1990. ;13::1057.–61.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 78

    Armstrong DG. The 10-g monofilament: the diagnostic divining rod for the diabetic foot?. Diabetes Care 2000. ;23::887..

  • 79

    Armstrong DG, Nguyen HC. Improvement in healing with aggressive edema reduction after debridement of foot infection in persons with diabetes. .Arch Surg 2000. ;135::1405.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 80

    Jones V. Debridement of diabetic foot lesions. .The Diabetic Foot 1998. ;1::88.–94.

  • 81

    Rauwerda JA. Foot debridement: anatomic knowledge is mandatory. .Diabetes Metab Res Rev 2000. ;16:(Suppl 1):S23.–6.

  • 82

    Smith J, Thow J. Is debridement effective for diabetic foot ulcers? A systematic review: 1. .The Diabetic Foot 2001. ;1::10.–4.

  • 83

    Grayson ML, Gibbons GW, Balogh K, Levin E, Karchmer AW. Probing to bone in infected pedal ulcers: a clinical sign of underlying osteomyelitis in diabetic patients. .JAMA 1995. ;273::721.–3.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 84

    Lipsky BA, Pecoraro RE, Larson SA, Hanley ME, Ahroni JH. Outpatient management of uncomplicated lower-extremity infections in diabetic patients. .Arch Intern Med 1990. ;150::790.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 85

    Pellizzer G, Strazzabosco M, Presi S, et al. Deep tissue biopsy vs. superficial swab culture monitoring in the microbiological assessment of limb-threatening diabetic foot infection. .Diabet Med 2001. ;18::822.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 86

    Johnson S, Lebahn F, Peterson LR, Gerding DN. Use of an anaerobic collection and transport swab device to recover anaerobic bacteria from infected foot ulcers in diabetics. .Clin Infect Dis 1995. ;20:(Suppl 2):S289.–90.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 87

    Lee PC, Turnidge J, McDonald PJ. Fine-needle aspiration biopsy in diagnosis of soft tissue infections. .J Clin Microbiol 1985. ;22::80.–3.

  • 88

    Enderle MD, Coerper S, Schweizer HP, et al. Correlation of imaging techniques to histopathology in patients with diabetic foot syndrome and clinical suspicion of chronic osteomyelitis: the role of high-resolution ultrasound. .Diabetes Care 1999. ;22::294.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 89

    Williamson BR, Teates CD, Phillips CD, Croft BY. Computed tomography as a diagnostic aid in diabetic and other problem feet. .Clin Imaging 1989. ;13::159.–63.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 90

    Morrison WB, Ledermann HP, Schweitzer ME. MR imaging of inflammatory conditions of the ankle and foot. .Magn Reson Imaging Clin N Am 2001. ;9::615.–37, xi–xii.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 91

    Boutin RD, Brossmann J, Sartoris DJ, Reilly D, Resnick D. Update on imaging of orthopedic infections. .Orthop Clin North Am 1998. ;29::41.–66.

  • 92

    Ledermann HP, Morrison WB, Schweitzer ME. MR image analysis of pedal osteomyelitis: distribution, patterns of spread, and frequency of associated ulceration and septic arthritis. .Radiology 2002. ;223::747.–55.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 93

    Ledermann HP, Morrison WB, Schweitzer ME. Pedal abscesses in patients suspected of having pedal osteomyelitis: analysis with MR imaging. .Radiology 2002. ;224::649.–55.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 94

    Becker W. Imaging osteomyelitis and the diabetic foot. .Q J Nucl Med 1999. ;43::9.–20.

  • 95

    Greenspan A, Stadalnik RC. A musculoskeletal radiologist’s view of nuclear medicine. .Semin Nucl Med 1997. ;27::372.–85.

  • 96

    Palestro CJ, Torres MA. Radionuclide imaging in orthopedic infections. .Semin Nucl Med 1997. ;27::334.–45.

  • 97

    Unal SN, Birinci H, Baktiroglu S, Cantez S. Comparison of Tc-99m methylene diphosphonate, Tc-99m human immune globulin, and Tc99m-labeled white blood cell scintigraphy in the diabetic foot. .Clin Nucl Med 2001. ;26::1016.–21.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 98

    Wagner FW Jr. The diabetic foot. .Orthopedics 1987. ;10::163.–72.

  • 99

    Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB, Boulton AJ. A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems. .Diabetes Care 2001. ;24::84.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 100

    Pecoraro RE. Diabetic skin ulcer classification for clinical investigations. .Clinical Materials 1991. ;8::257.–62.

  • 101

    Pecoraro RE, Reiber GE. Classification of wounds in diabetic amputees. .Wounds 1990. ;2::65.–73.

  • 102

    Lavery LA, Armstrong DG, Harkless LB. Classification of diabetic foot wounds. .J Foot Ankle Surg 1996. ;35::528.–31.

  • 103

    Levin ME. Classification of diabetic foot wounds [editorial]. .Diabetes Care 1998. ;21::681..

  • 104

    Apelqvist J, Castenfors J, Larrson J, Stenstrom A, Agardh CD. Wound classification is more important than site of ulceration in the outcome of diabetic foot ulcers. .Diabet Med 1989. ;6::526.–30.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 105

    Jeffcoate WJ, Macfarlane RM, Fletcher EM. The description and classification of diabetic foot lesions. .Diabet Med 1993. ;10::676.–9.

  • 106

    Macfarlane R, Jeffcoate W. Classification of diabetic foot ulcers: the S(AD) SAD system. .The Diabetic Foot 1999. ;2::123.–31.

  • 107

    Armstrong DG, Lavery LA, Harkless LB. Validation of a diabetic wound classification system: the contribution of depth, infection, and ischemia to risk of amputation. .Diabetes Care 1998. ;21::855.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 108

    Foster A, Edmonds ME. Simple staging system: a tool for diagnosis and management. .The Diabetic Foot 2000. ;3::56.–62.

  • 109

    Trengove NJ, Stacey MC, McGechie DF, Mata S. Qualitative bacteriology and leg ulcer healing. .J Wound Care 1996. ;5::277.–80.

  • 110

    Kingsley A. The wound infection continuum and its application to clinical practice. .Ostomy Wound Manage 2003. ;49::1.–7.

  • 111

    O’Meara SM, Cullum NA, Majid M, Sheldon TA. Systematic review of antimicrobial agents used for chronic wounds. .Br J Surg 2001. ;88::4.–21.

  • 112

    Robson MC, Mannari RJ, Smith PD, Payne WG. Maintenance of wound bacterial balance. .Am J Surg 1999. ;178::399.–402.

  • 113

    Bowler PG. The 105 bacterial growth guideline: reassessing its clinical relevance in wound healing. .Ostomy Wound Manage 2003. ;49::44.–53.

  • 114

    Edmonds M, Foster A. The use of antibiotics in the diabetic foot. .Am J Surg 2004. ;187::25S.–28S.

  • 115

    Chantelau E, Tanudjaja T, Altenhofer F, Ersanli Z, Lacigova S, Metzger C. Antibiotic treatment for uncomplicated neuropathic forefoot ulcers in diabetes: a controlled trial. .Diabet Med 1996. ;13::156.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 116

    Hirschl M, Hirschl AM. Bacterial flora in mal perforant and antimicrobial treatment with ceftriaxone. .Chemotherapy 1992. ;38::275.–80.

  • 117

    Cutting K, Harding K. Criteria for identifying wound infection. .J Wound Care 1994. ;3::198.–201.

  • 118

    Schultz GS, Sibbald RG, Falanga V, et al. Wound bed preparation: a systematic approach to wound management. .Wound Repair Regen 2003. ;11:(Suppl 1):S1.–28.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 119

    Lipsky BA. A current approach to diabetic foot infections. .Curr Infect Dis Rep 1999. ;1::253.–60.

  • 120

    Mancini L, Ruotolo V. Infection of the diabetic foot. .Rays 1997. ;22::544.–9.

  • 121

    Lipsky BA, Itani K, Norden C. Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin-sulbactam/amoxicillin-clavulanate. .Clin Infect Dis 2004. ;38::17.–24.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 122

    Leichter SB, Allweiss P, Harley J, et al. Clinical characteristics of diabetic patients with serious pedal infections. .Metabolism 1988. ;37::22.–4.

  • 123

    Chang BB, Darling RC 3rd, Paty PS, Lloyd WE, Shah DM, Leather RP. Expeditious management of ischemic invasive foot infections. .Cardiovasc Surg 1996. ;4::792.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 124

    Rubinstein A, Pierce CE Jr., Bloomgarden Z. Rapid healing of diabetic foot ulcers with continuous subcutaneous insulin infusion. .Am J Med 1983. ;75::161.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 125

    Asfar SK, al-Arouj M, al-Nakhi A, Baraka A, Juma T, Johny M. Foot infections in diabetics: the antibiotic choice. .Can J Surg 1993. ;36::170.–2.

  • 126

    West NJ. Systemic antimicrobial treatment of foot infections in diabetic patients. .Am J Health Syst Pharm 1995. ;52::1199.–207; quiz, 1239–40.

  • 127

    Cunha BA. Antibiotic selection for diabetic foot infections: a review. .J Foot Ankle Surg 2000. ;39::253.–7.

  • 128

    Krikava K, Pospisil M. The diabetic foot syndrome—antibiotic therapy [in Czech]. .Rozhl Chir 1999. ;78::295.–8.

  • 129

    Lipsky BA. Evidence-based antibiotic therapy of diabetic foot infections. .FEMS Immunol Med Microbiol 1999. ;26::267.–76.

  • 130

    Lipsky BA, McDonald D, Litka P. Treatment of infected diabetic foot ulcers: topical MSI-78 vs. oral ofloxacin. .Diabetologia 1997. ;40::482..

  • 131

    Raymakers JT, Schaper NC, van der Heyden JJ, Tordior JH, Kitslaar PJ. Penetration of ceftazidime into bone from severely ischaemic limbs. .J Antimicrob Chemother 1998. ;42::543.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 132

    Seabrook GR, Edmiston CE, Schmitt DD, Krepel C, Bandyk DF, Towne JB. Comparison of serum and tissue antibiotic levels in diabetes-related foot infections. .Surgery 1991. ;110::671.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 133

    Duckworth C, Fisher JF, Carter SA, et al. Tissue penetration of clindamycin in diabetic foot infections. .J Antimicrob Chemother 1993. ;31::581.–4.

  • 134

    Legat FJ, Maier A, Dittrich P, et al. Penetration of fosfomycin into inflammatory lesions in patients with cellulitis or diabetic foot syndrome. .Antimicrob Agents Chemother 2003. ;47::371.–4.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 135

    Muller M, Brunner M, Hollenstein U, et al. Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non–insulin-dependent diabetes mellitus patients. .Antimicrob Agents Chemother 1999. ;43::2056.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 136

    Kuck EM, Bouter KP, Hoekstra JB, Conemans JM, Diepersloot RJ. Tissue concentrations after a single-dose, orally administered ofloxacin in patients with diabetic foot infections. .Foot Ankle Int 1998. ;19::38.–40.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 137

    Mueller-Buehl U, Diehm C, Gutzler F, Adam D. Tissue concentrations of ofloxacin in necrotic foot lesions of diabetic and non-diabetic patients with peripheral arterial occlusive disease. .Vasa 1991. ;20::17.–21.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 138

    Raymakers JT, Houben AJ, van der Heyden JJ, Tordoir JH, Kitslaar PJ, Schaper NC. The effect of diabetes and severe ischaemia on the penetration of ceftazidime into tissues of the limb. .Diabet Med 2001. ;18::229.–34.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 139

    Fierer J, Daniel D, Davis C. The fetid foot: lower-extremity infections in patients with diabetes mellitus. .Rev Infect Dis 1979. ;1::210.–7.

  • 140

    Hughes CE, Johnson CC, Bamberger DM, et al. Treatment and long-term follow-up of foot infections in patients with diabetes or ischemia: a randomized, prospective, double-blind comparison of cefoxitin and ceftizoxime. .Clin Ther 1987. ;10:(Suppl A):36.–49.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 141

    LeFrock JL, Blais F, Schell RF, et al. Cefoxitin in the treatment of diabetic patients with lower extremity infections. .Infect Surg 1983. :361.–70.

  • 142

    Erstad BL, McIntyre KE. Prospective, randomized comparison of ampicillin/sulbactam and cefoxitin for diabetic foot infections. .Vascular Surgery 1997. ;31::419.–26.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 143

    File TM Jr., Tan JS. Amdinocillin plus cefoxitin versus cefoxitin alone in therapy of mixed soft tissue infections (including diabetic foot infections). .Am J Med 1983. ;75::100.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 144

    Anania WC, Chinkes SL, Rosen RC, Turner PR, Helfand RE. A selective clinical trial of ceftizoxime. .J Am Podiatr Med Assoc 1987. ;77::648.–52.

  • 145

    Lobmann R, Ambrosch A, Seewald M, et al. Antibiotic therapy for diabetic foot infections: comparison of cephalosporins with chinolones. .Diabetes Nutr Metab 2004. ;17::156.–62.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 146

    Lipsky BA, Baker PD, Landon GC, Fernau R. Antibiotic therapy for diabetic foot infections: comparison of two parenteral-to-oral regimens. .Clin Infect Dis 1997. ;24::643.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 147

    Grayson ML, Gibbons GW, Habershaw GM, et al. Use of ampicillin/sulbactam versus imipenem/cilastatin in the treatment of limb-threatening foot infections in diabetic patients. .Clin Infect Dis 1994. ;18::683.–93.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 148

    Akova M, Ozcebe O, Gullu I, et al. Efficacy of sulbactam-ampicillin for the treatment of severe diabetic foot infections. .J Chemother 1996. ;8::284.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 149

    Gerards V, Schiewe U, Gerards HH, Machka K, Hobel W, Meister W. Amoxicillin/clavulanic acid in therapy of bacterial infections of the diabetic foot: results of an observational study [in German]. .MMW Fortschr Med 2000. ;142::187.–94.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 150

    Graham DR, Talan DA, Nichols RL, et al. Once-daily, high-dose levofloxacin versus ticarcillin-clavulanate alone or followed by amoxicillin-clavulanate for complicated skin and skin-structure infections: a randomized, open-label trial. .Clin Infect Dis 2002. ;35::381.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 151

    File TM Jr., Tan JS. Ticarcillin-clavulanate therapy for bacterial skin and soft tissue infections. .Rev Infect Dis 1991. ;13:(Suppl 9):S733.–6.

  • 152

    Zeillemaker AM, Veldkamp KE, van Kraaij MG, Hoekstra JB, Hoynck van Papendrecht AA, Diepersloot RJ. Piperacillin/tazobactam therapy for diabetic foot infection. .Foot Ankle Int 1998. ;19::169.–72.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 153

    Marvaso A, Esposito S, Noviello S, et al. Outpatient Parenteral Antibiotic Therapy (OPAT) of diabetic foot infections with piperacillin/tazobactam [in Italian]. .Infez Med 2002. ;10::230.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 154

    Siami FS, LaFleur BJ, Siami GA. Clinafloxacin versus piperacillin/tazobactam in the treatment of severe skin and soft-tissue infections in adults at a Veterans Affairs medical center. .Clin Ther 2002. ;24::59.–72.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 155

    Peterson LR, Lissack LM, Canter K, Fasching CE, Clabots C, Gerding DN. Therapy of lower extremity infections with ciprofloxacin in patients with diabetes mellitus, peripheral vascular disease, or both. .Am J Med 1989. ;86::801.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 156

    Beam TR Jr., Gutierrez I, Powell S, Hewitt R, Hocko M, Brackett M. Prospective study of the efficacy and safety of oral and intravenous ciprofloxacin in the treatment of diabetic foot infections. .Rev Infect Dis 1989. ;11: (Suppl 5):S163..

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 157

    Sesin GP, Paszko A, O’Keefe E. Oral clindamycin and ciprofloxacin therapy for diabetic foot infections. .Pharmacotherapy 1990. ;10::154.–6.

  • 158

    Daniel R, Group TS. Once-daily oral trovafloxacin in the treatment of diabetic foot infections: results of an open-label, non-comparative, multicentre trial. .Drugs 1999. ;58::291.–2.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 159

    Calandra GB, Raupp W, Brown KR. Imipenem/cilastatin treatment of lower extremity skin and soft tissue infections in diabetics. .Scand J Infect Dis Suppl 1987. ;52::15.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 160

    Bouter KP, Visseren FLJ, van Loenhour RMM, Bartelink AKM, Erkelens DW, Diepersloot RJA. Treatment of diabetic foot infection: an open randomised comparison of imipenem/cilastatin and piperacillin/clindamyin combination therapy. .Int J Antimicrob Agents 1996. ;7::143.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 161

    Gesser R, McCarroll K, Woods G. Efficacy of ertapenem for treatment of diabetic lower extremity infections: results of a comparative trial versus pipericillin-tazobactam [abstract 321]. In: Program and abstracts of the 41st Annual Meeting of the Infectious Diseases Society of America (San Diego). Alexandria, VA: Infectious Diseases Society of America. ,2003. :88.

    • PubMed
    • Export Citation
  • 162

    Torres A, Ramirez-Ronda CH. Aztreonam in the treatment of soft tissue infections including diabetic foot infections. .Bol Asoc Med P R 1985. ;77::191.–4.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 163

    Lipsky BA. Daptomycin for treating diabetic ulcer infections [abstract B-115]. In: Program and abstracts of the Annual Scientific Meeting of the American College of Foot & Ankle Surgery (San Diego). Chicago: American College of Foot & Ankle Surgery. ,2004. .

    • PubMed
    • Export Citation
  • 164

    Steffen C, O’Rourke S. Surgical management of diabetic foot complications: the Far North Queensland profile. .Aust N Z J Surg 1998. ;68::258.–60.

  • 165

    Giurini JM, Rosenblum BI. The role of foot surgery in patients with diabetes. .Clin Podiatr Med Surg 1995. ;12::119.–27.

  • 166

    Bridges RM Jr., Deitch EA. Diabetic foot infections: pathophysiology and treatment. .Surg Clin North Am 1994. ;74::537.–55.

  • 167

    Gill LH. Foot surgery in the patient with diabetes. .J South Orthop Assoc 1994. ;3::261.–7.

  • 168

    Chaytor ER. Surgical treatment of the diabetic foot. .Diabetes Metab Res Rev 2000. ;16:(Suppl 1):S66.–9.

  • 169

    Armstrong DG, Frykberg RG. Classifying diabetic foot surgery: toward a rational definition. .Diabet Med 2003. ;20::329.–31.

  • 170

    Scher KS, Steele FJ. The septic foot in patients with diabetes. .Surgery 1988. ;104::661.–6.

  • 171

    Pinzur MS, Sage R, Abraham M, Osterman H. Limb salvage in infected lower extremity gangrene. .Foot Ankle 1988. ;8::212.–5.

  • 172

    Tan JS, Friedman NM, Hazelton-Miller C, Flanagan JP, File TM Jr. Can aggressive treatment of diabetic foot infections reduce the need for above-ankle amputation?. Clin Infect Dis 1996. ;23::286.–91.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 173

    Ha Van G, Siney H, Danan JP, Sachon C, Grimaldi A. Treatment of osteomyelitis in the diabetic foot: contribution of conservative surgery. .Diabetes Care 1996. ;19::1257.–60.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 174

    Piaggesi A, Schipani E, Campi F, et al. Conservative surgical approach versus non-surgical management for diabetic neuropathic foot ulcers: a randomized trial. .Diabet Med 1998. ;15::412.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 175

    Bose K. A surgical approach for the infected diabetic foot. .Int Orthop 1979. ;3::177.–81.

  • 176

    Brodsky JW, Schneidler C. Diabetic foot infections. .Orthop Clin North Am 1991. ;22::473.–89.

  • 177

    Connolly JE, Wrobel JS, Anderson RF. Primary closure of infected diabetic foot wounds: a report of closed instillation in 30 cases. .J Am Podiatr Med Assoc 2000. ;90::175.–82.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 178

    Pinzur MS. Amputation level selection in the diabetic foot. .Clin Orthop 1993. :68.–70.

  • 179

    Pinzur MS, Pinto MA, Schon LC, Smith DG. Controversies in amputation surgery. .Instr Course Lect 2003. ;52::445.–51.

  • 180

    Durham JR, McCoy DM, Sawchuk AP, et al. Open transmetatarsal amputation in the treatment of severe foot infections. .Am J Surg 1989. ;158::127.–30.

  • 181

    Benton GS, Kerstein MD. Cost effectiveness of early digit amputation in the patient with diabetes. .Surg Gynecol Obstet 1985. ;161::523.–4.

  • 182

    Field CK, Kerstein MD. Cost-benefit analysis of lower-extremity amputation: ethical considerations. .Wounds 1993. ;5::10.–3.

  • 183

    Van Damme H, Rorive M, Martens De Noorthout BM, Quaniers J, Scheen A, Limet R. Amputations in diabetic patients: a plea for footsparing surgery. .Acta Chir Belg 2001. ;101::123.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 184

    Khammash MR, Obeidat KA. Prevalence of ischemia in diabetic foot infection. .World J Surg 2003. ;27::797.–9.

  • 185

    Lepantalo M, Biancari F, Tukiainen E. Never amputate without consultation of a vascular surgeon. .Diabetes Metab Res Rev 2000. ;16:(Suppl 1):S27.–32.

  • 186

    Gibbons GW. Lower extremity bypass in patients with diabetic foot ulcers. .Surg Clin North Am 2003. ;83::659.–69.

  • 187

    Holstein PE, Sorensen S. Limb salvage experience in a multidisciplinary diabetic foot unit. .Diabetes Care 1999. ;22:(Suppl 2):B97.–103.

  • 188

    Estes JM, Pomposelli FB Jr. Lower extremity arterial reconstruction in patients with diabetes mellitus. .Diabet Med 1996. ;13:(Suppl 1):S43.–7.

  • 189

    Akbari CM, Pomposelli FB Jr., Gibbons GW, et al. Lower extremity revascularization in diabetes: late observations. .Arch Surg 2000. ;135::452.–6.

  • 190

    Taylor LM Jr., Porter JM. The clinical course of diabetics who require emergent foot surgery because of infection or ischemia. .J Vasc Surg 1987. ;6::454.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 191

    Steed DL, Donohoe D, Webster MW, Lindsley L. Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group. .J Am Coll Surg 1996. ;183::61.–4.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 192

    Smith J, Thow J. Is debridement effective for diabetic foot ulcers? A systematic review: 2. .The Diabetic Foot 2001. ;4::77.–80.

  • 193

    Lewis R, Whiting P, ter Riet G, O’Meara S, Galanville J. A rapid systematic review of the clinical effectiveness and cost effectiveness of debriding agents in treating surgical wounds healing by secondary intention: NHS HTA Programme, the National Institute of Clinical Excellence, NHS Centre for Reviews and Dissemination University of York. ,2000. :1–8.

    • Crossref
    • PubMed
    • Export Citation
  • 194

    Armstrong DG, Lavery LA, Vazquez JR, Nixon BP, Boulton AJ. How and why to surgically debride neuropathic diabetic foot wounds. .J Am Podiatr Med Assoc 2002. ;92::402.–4.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 195

    Singhal A, Reis ED, Kerstein MD. Options for nonsurgical debridement of necrotic wounds. .Adv Skin Wound Care 2001. ;14::96.–100.

  • 196

    O’Meara SO, Cullum N, Majid M, Sheldon T. Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration. .Health Technol Assess 2000. ;4::1.–237.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 197

    Nwomeh BC, Yager DR, Cohen IK. Physiology of the chronic wound. .Clin Plast Surg 1998. ;25::341.–56.

  • 198

    Eaglstein WH, Falanga V. Chronic wounds. .Surg Clin North Am 1997. ;77::689.–700.

  • 199

    Hogge J, Krasner D, Nguyen H, Harkless LB, Armstrong DG. The potential benefits of advanced therapeutic modalities in the treatment of diabetic foot wounds. .J Am Podiatr Med Assoc 2000. ;90::57.–65.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 200

    Armstrong DG, Nguyen HC, Lavery LA, van Schie CH, Boulton AJ, Harkless LB. Off-loading the diabetic foot wound: a randomized clinical trial. .Diabetes Care 2001. ;24::1019.–22.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 201

    Armstrong DG, Lavery LA. Evidence-based options for off-loading diabetic wounds. .Clin Podiatr Med Surg 1998. ;15::95.–104.

  • 202

    Boulton AJ. Pressure and the diabetic foot: clinical science and offloading techniques. .Am J Surg 2004. ;187::17S.–24S.

  • 203

    Espensen EH, Nixon BP, Lavery LA, Armstrong DG. Use of subatmospheric (VAC) therapy to improve bio-engineered tissue grafting in diabetic foot wounds. .J Am Podiatr Med Assoc 2002. ;92::395.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 204

    Joseph E, Hamori CA, Bergman S, Roaf E, Swann NF, Anastasi GW. A prospective, randomized trial of vacuum-assisted closure versus standard therapy of chronic non-healing wounds. .Wounds 2000. ;12::60.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 205

    McCallon SK, Knight CA, Valiulus JP, Cunningham MW, McCulloch JM, Farinas LP. Vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds. .Ostomy Wound Manage 2000. ;46::28.–32, 34.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 206

    Armstrong DG, Lavery LA, Abu-Rumman P, et al. Outcomes of subatmospheric pressure dressing therapy on wounds of the diabetic foot. .Ostomy Wound Manage 2002. ;48::64.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 207

    Nagai MK, Embil JM. Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers. .Expert Opin Biol Ther 2002. ;2::211.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 208

    Embil JM, Papp K, Sibbald G, et al. Recombinant human platelet–derived growth factor-BB (becaplermin) for healing chronic lower extremity diabetic ulcers: an open-label clinical evaluation of efficacy. .Wound Repair Regen 2000. ;8::162.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 209

    Knighton DR, Fiegel VD. Growth factors and comprehensive surgical care of diabetic wounds [review]. .Curr Opin Gen Surg 1993. :32.–9.

  • 210

    Smiell JM. Clinical safety of becaplermin (rhPDGF-BB) gel. Becaplermin Studies Group. .Am J Surg 1998. ;176::68S.–73S.

  • 211

    Steed DL. Growth factors in the treatment of diabetic foot ulcers. .Wounds 1993. ;5::80.–3.

  • 212

    Robson MC, Mustoe TA, Hunt TK. The future of recombinant growth factors in wound healing. .Am J Surg 1998. ;176::80S.–82S.

  • 213

    Williams RL, Armstrong DG. Wound healing: new modalities for a new millennium. .Clin Podiatr Med Surg 1998. ;15::117.–28.

  • 214

    Edmonds M, Bates M, Doxford M, Gough A, Foster A. New treatments in ulcer healing and wound infection. .Diabetes Metab Res Rev 2000. ;16:(Suppl 1):S51.–4.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 215

    Browne AC, Vearncombe M, Sibbald RG. High bacterial load in asymptomatic diabetic patients with neurotrophic ulcers retards wound healing after application of Dermagraft. .Ostomy Wound Manage 2001. ;47::44.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 216

    Veves A, Falanga V, Armstrong DG, Sabolinski ML. Graft-skin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial. .Diabetes Care 2001. ;24::290.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 217

    Bowler PG. Wound pathophysiology, infection and therapeutic options. .Ann Med 2002. ;34::419.–27.

  • 218

    Wright JB, Lam K, Hansen D, Burrell RE. Efficacy of topical silver against fungal burn wound pathogens. .Am J Infect Control 1999. ;27::344.–50.

  • 219

    Mayer DA, Tsapogas MJ. Povidone-iodine and wound healing: a critical review. .Wounds 1993. ;5::14.–23.

  • 220

    Mumcuoglu KY. Clinical applications for maggots in wound care. .Am J Clin Dermatol 2001. ;2::219.–27.

  • 221

    Rayman A, Stansfield G, Woollard T, Mackie A, Rayman G. Use of larvae in the treatment of the diabetic necrotic foot. .The Diabetic Foot 1998. ;1::7.–13.

  • 222

    Claxton MJ, Armstrong DG, Short B, Vazquez JR, Boulton AJ. 5 Questions—and answers—about maggot debridement therapy. .Adv Skin Wound Care 2003. ;16::99.–102.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 223

    Peck KR, Son DW, Song JH, Kim S, Oh MD, Choe KW. Enhanced neutrophil functions by recombinant human granulocyte colony-stimulating factor in diabetic patients with foot infections in vitro. .J Korean Med Sci 2001. ;16::39.–44.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 224

    Gough A, Clapperton M, Rolando N, Foster AV, Philpott-Howard J, Edmonds ME. Randomised placebo-controlled trial of granulocyte colony-stimulating factor in diabetic foot infection. .Lancet 1997. ;350::855.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 225

    de Lalla F, Pelizzer G, Strazzabosco M, et al. Randomized prospective controlled trial of recombinant granulocyte colony-stimulating factor as adjunctive therapy for limb-threatening diabetic foot infection. .Antimicrob Agents Chemother 2001. ;45::1094.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 226

    Kastenbauer T, Hornlein B, Sokol G, Irsigler K. Evaluation of granulocyte colony-stimulating factor (Filgrastim) in infected diabetic foot ulcers. .Diabetologia 2003. ;46::27.–30.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 227

    Viswanathan V, Mahesh U, Jayaraman M, Shina K, Ramachandram A. Beneficial role of granulocyte colony-stimulating factor in foot infection in diabetic patients. .J Assoc Physicians India 2003. ;51::90.–1.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 228

    Lipsky BA, Berendt AR, Embil J, De Lalla F. Diagnosing and treating diabetic foot infections. .Diabetes Metab Res Rev 2004. ;20:(Suppl 1):S56.–64.

  • 229

    Bakker DJ. Hyperbaric oxygen therapy and the diabetic foot. .Diabetes Metab Res Rev 2000. ;16:(Suppl 1):S55.–8.

  • 230

    Kalani M, Jorneskog G, Naderi N, Lind F, Brismar K. Hyperbaric oxygen (HBO) therapy in treatment of diabetic foot ulcers: long-term follow-up. .J Diabetes Complications 2002. ;16::153.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 231

    Wang C, Schwaitzberg S, Berliner E, Zarin DA, Lau J. Hyperbaric oxygen for treating wounds: a systematic review of the literature. .Arch Surg 2003. ;138::272.–9; discussion 280.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 232

    Wunderlich RP, Peters EJ, Lavery LA. Systemic hyperbaric oxygen therapy: lower-extremity wound healing and the diabetic foot. .Diabetes Care 2000. ;23::1551.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 233

    Kranke P, Bennett M, Roeckl-Wiedmann I, Debus S. Hyperbaric oxygen therapy for chronic wounds. .Cochrane Database Syst Rev 2004. :CD004123..

  • 234

    Lee SS, Chen CY, Chan YS, Yen CY, Chao EK, Ueng SW. Hyperbaric oxygen in the treatment of diabetic foot infection. .Changgeng Yi Xue Za Zhi 1997. ;20::17.–22.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 235

    Armstrong DG, Lavery LA, Sariaya M, Ashry H. Leukocytosis is a poor indicator of acute osteomyelitis of the foot in diabetes mellitus. .J Foot Ankle Surg 1996. ;35::280.–3.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 236

    Kaleta JL, Fleischli JW, Reilly CH. The diagnosis of osteomyelitis in diabetes using erythrocyte sedimentation rate: a pilot study. .J Am Podiatr Med Assoc 2001. ;91::445.–50.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 237

    Eneroth M, Larsson J, Apelqvist J. Deep foot infections in patients with diabetes and foot ulcer: an entity with different characteristics, treatments, and prognosis. .J Diabetes Complications 1999. ;13::254.–63.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 238

    Upchurch GR Jr., Keagy BA, Johnson G Jr. An acute phase reaction in diabetic patients with foot ulcers. .Cardiovasc Surg 1997. ;5::32.–6.

  • 239

    Jeffcoate WJ, Lipsky BA. Controversies in diagnosing and managing osteomyelitis of the foot in diabetes. .Clin Infect Dis 2004. ;39:(Suppl 2):S115.–22.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 240

    Lipsky BA. Osteomyelitis of the foot in diabetic patients. .Clin Infect Dis 1997. ;25::1318.–26.

  • 241

    Snyder RJ, Cohen MM, Sun C, Livingston J. Osteomyelitis in the diabetic patient: diagnosis and treatment. Part 1: overview, diagnosis, and microbiology. .Ostomy Wound Manage 2001. ;47::18.–22, 25–30; quiz 31–2.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 242

    Snyder RJ, Cohen MM, Sun C, Livingston J. Osteomyelitis in the diabetic patient: diagnosis and treatment. Part 2: medical, surgical, and alternative treatments. .Ostomy Wound Manage 2001. ;47::24.–30, 32–41; quiz 42–3.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 243

    Embil JM. The management of diabetic foot osteomyelitis. .The Diabetic Foot 2000. ;3::76.–84.

  • 244

    Eckman MH, Greenfield S, Mackey WC, et al. Foot infections in diabetic patients: decision and cost-effectiveness analyses. .JAMA 1995. ;273::712.–20.

  • 245

    Newman LG, Waller J, Palestro CJ, et al. Unsuspected osteomyelitis in diabetic foot ulcers: diagnosis and monitoring by leukocyte scanning with indium in 111 oxyquinoline. .JAMA 1991. ;266::1246.–51.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 246

    Rajbhandari SM, Sutton M, Davies C, Tesfaye S, Ward JD. “Sausage toe”: a reliable sign of underlying osteomyelitis. .Diabet Med 2000. ;17::74.–7.

  • 247

    Shults DW, Hunter GC, McIntyre KE, Parent FN, Piotrowski JJ, Bernhard VM. Value of radiographs and bone scans in determining the need for therapy in diabetic patients with foot ulcers. .Am J Surg 1989. ;158::525.–9; discussion 529–30.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 248

    Lipman BT, Collier BD, Carrera GF, et al. Detection of osteomyelitis in the neuropathic foot: nuclear medicine, MRI and conventional radiography. .Clin Nucl Med 1998. ;23::77.–82.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 249

    Bonham P. A critical review of the literature: part 1: diagnosing osteomyelitis in patients with diabetes and foot ulcers. .J Wound Ostomy Continence Nurs 2001. ;28::73.–88.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 250

    Bonham P. A critical review of the literature: part II: antibiotic treatment of osteomyelitis in patients with diabetes and foot ulcers. .J Wound Ostomy Continence Nurs 2001. ;28::141.–9.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 251

    Tan JS, File TM Jr. Diagnosis and treatment of diabetic foot infections. .Baillieres Best Pract Res Clin Rheumatol 1999. ;13::149.–61.

  • 252

    Maugendre D, Poirier JY. Nuclear medicine in the diagnosis of diabetic foot osteomyelitis [in French]. .Diabetes Metab 2001. ;27::396.–400.

  • 253

    Rosenthall L. Radionuclide investigation of osteomyelitis. .Curr Opin Radiol 1992. ;4::62.–9.

  • 254

    Newman LG. Imaging techniques in the diabetic foot. .Clin Podiatr Med Surg 1995. ;12::75.–86.

  • 255

    Jay PR, Michelson JD, Mizel MS, Magid D, Le T. Efficacy of three-phase bone scans in evaluating diabetic foot ulcers. .Foot Ankle Int 1999. ;20::347.–55.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 256

    Levine SE, Neagle CE, Esterhai JL, Wright DG, Dalinka MK. Magnetic resonance imaging for the diagnosis of osteomyelitis in the diabetic patient with a foot ulcer. .Foot Ankle Int 1994. ;15::151.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 257

    Marcus CD, Ladam-Marcus VJ, Leone J, Malgrange D, Bonnet-Gausserand FM, Menanteau BP. MR imaging of osteomyelitis and neuropathic osteoarthropathy in the feet of diabetics. .Radiographics 1996. ;16::1337.–48.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 258

    Ledermann HP, Schweitzer ME, Morrison WB. Nonenhancing tissue on MR imaging of pedal infection: characterization of necrotic tissue and associated limitations for diagnosis of osteomyelitis and abscess. .AJR Am J Roentgenol 2002. ;178::215.–22.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 259

    Vesco L, Boulahdour H, Hamissa S, et al. The value of combined radionuclide and magnetic resonance imaging in the diagnosis and conservative management of minimal or localized osteomyelitis of the foot in diabetic patients. .Metabolism 1999. ;48::922.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 260

    Wrobel JS, Connolly JE. Making the diagnosis of osteomyelitis: the role of prevalence. .J Am Podiatr Med Assoc 1998. ;88::337.–43.

  • 261

    Poirier JY, Garin E, Derrien C, et al. Diagnosis of osteomyelitis in the diabetic foot with a 99mTc-HMPAO leucocyte scintigraphy combined with a 99mTc-MDP bone scintigraphy. .Diabetes Metab 2002. ;28::485.–90.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 262

    Rubello D, Casara D, Maran A, Avogaro A, Tiengo A, Muzzio PC. Role of antigranulocyte Fab′ fragment antibody scintigraphy (LeukoScan) in evaluating bone infection: acquisition protocol, interpretation criteria and clinical results. .Nucl Med Commun 2004. ;25::39.–47.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 263

    Palestro CJ, Caprioli R, Love C, et al. Rapid diagnosis of pedal osteomyelitis in diabetics with a technetium-99m–labeled monoclonal antigranulocyte antibody. .J Foot Ankle Surg 2003. ;42::2.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 264

    Harwood SJ, Valdivia S, Hung G-L, Quenzer RW. Use of sulesomab, a radiolabeled antibody fragment, to detect osteomyelitis in diabetic patients with foot ulcers by leukocintigraphy. .Clin Infect Dis 1999. ;28::1200.–5.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 265

    Mader JT, Ortiz M, Calhoun JH. Update on the diagnosis and management of osteomyelitis. .Clin Podiatr Med Surg 1996. ;13::701.–24.

  • 266

    Wheat J. Diagnostic strategies in osteomyelitis. .Am J Med 1985. ;78::218.–24.

  • 267

    Howard CB, Einhorn M, Dagan R, Yagupski P, Porat S. Fine-needle bone biopsy to diagnose osteomyelitis. .J Bone Joint Surg Br 1994. ;76::311.–4.

  • 268

    Khatri G, Wagner DK, Sohnle PG. Effect of bone biopsy in guiding antimicrobial therapy for osteomyelitis complicating open wounds. .Am J Med Sci 2001. ;321::367.–71.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 269

    White LM, Schweitzer ME, Deely DM, Gannon F. Study of osteomyelitis: utility of combined histologic and microbiologic evaluation of percutaneous biopsy samples. .Radiology 1995. ;197::840.–2.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 270

    Zuluaga AF, Galvis W, Jaimes F, Vesga O. Lack of microbiological concordance between bone and non-bone specimens in chronic osteomyelitis: an observational study. .BMC Infect Dis 2002. ;2::8..

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 271

    Venkatesan P, Lawn S, Macfarlane RM, Fletcher EM, Finch RG, Jeffcoate WJ. Conservative management of osteomyelitis in the feet of diabetic patients. .Diabet Med 1997. ;14::487.–90.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 272

    Senneville E, Yazdanpanah Y, Cazaubiel M, et al. Rifampicin-ofloxacin oral regimen for the treatment of mild to moderate diabetic foot osteomyelitis. .J Antimicrob Chemother 2001. ;48::927.–30.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 273

    Pittet D, Wyssa B, Herter-Clavel C, Kursteiner K, Vaucher J, Lew PD. Outcome of diabetic foot infections treated conservatively: a retrospective cohort study with long-term follow-up. .Arch Intern Med 1999. ;159::851.–6.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 274

    Yadlapalli N, Vaishnar A, Sheehan P. Conservative management of diabetic foot ulcers complicated by osteomyelitis. .Wounds 2002. ;14::31.–5.

  • 275

    Nix DK, Cumbo TJ, Kuritzky P, Devito JM, Shentag JJ. Oral ciprofloxacin in the treatment of serious soft tissue and bone infection: efficacy, safety, and pharmacokinetics. .Am J Med 1987. ;82:(Suppl 4A):146.–53.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 276

    Bamberger DM, Daus GP, Gerding DN. Osteomyelitis in the feet of diabetic patients: long-term results, prognostic factors, and the role of antimicrobial and surgical therapy. .Am J Med 1987. ;83::653.–60.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 277

    Roeder B, Van Gils CC, Maling S. Antibiotic beads in the treatment of diabetic pedal osteomyelitis. .J Foot Ankle Surg 2000. ;39::124.–30.

  • 278

    Wininger DA, Fass RJ. Antibiotic-impregnated cement and beads for orthopedic infections. .Antimicrob Agents Chemother 1996. ;40::2675.–9.

  • 279

    Yamashita Y, Uchida A, Yamakawa T, Shinto Y, Araki N, Kato K. Treatment of chronic osteomyelitis using calcium hydroxyapatite ceramic implants impregnated with antibiotic. .Int Orthop 1998. ;22::247.–51.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 280

    Jacobs AM, Siefert AM, Kirisits TJ, Protzel HR. Use of antibiotic-loaded bone cement in the management of common infections of the foot and ankle. .Clin Podiatr Med Surg 1990. ;7::523.–44.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 281

    Fox HR, Karchmer AW. Management of diabetic foot infections, including the use of home intravenous antibiotic therapy. .Clin Podiatr Med Surg 1996. ;13::671.–82.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 282

    Tice A, Hoaglund P, Shoultz DA. Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy. .Am J Med 2003. ;114::723.–8.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 283

    Diamantopoulos EJ, Haritos D, Yfandi G, et al. Management and outcome of severe diabetic foot infections. .Exp Clin Endocrinol Diabetes 1998. ;106::346.–52.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 284

    Eneroth M, Apelqvist J, Stenstrom A. Clinical characteristics and outcome in 223 diabetic patients with deep foot infections. .Foot Ankle Int 1997. ;18::716.–22.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 285

    Balsells M, Viade J, Millan M, et al. Prevalence of osteomyelitis in non-healing diabetic foot ulcers: usefulness of radiologic and scintigraphic findings. .Diabetes Res Clin Pract 1997. ;38::123.–7.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 286

    Wong YS, Lee JC, Yu CS, Low BY. Results of minor foot amputations in diabetic mellitus. .Singapore Med J 1996. ;37::604.–6.

  • 287

    Kaufman J, Breeding L, Rosenberg N. Anatomic location of acute diabetic foot infection: its influence on the outcome of treatment. .Am Surg 1987. ;53::109.–12.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 288

    Perencevich EN, Kaye KS, Strausbaugh LJ, Fisman DN, Harris AD. Acceptable rates of treatment failure in osteomyelitis involving the diabetic foot: a survey of infectious diseases specialists. Infectious Diseases Society of America Emerging Infections Network. .Clin Infect Dis 2004. ;38::976.–82.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 289

    Apelqvist J, Bakker K, van Houtum WH, Nabuurs-Franssen MH, Schaper NC. International consensus and practical guidelines on the management and the prevention of the diabetic foot. .Diabetes Metab Res Rev 2000. ;16:(Suppl 1):S84.–92.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 290

    Inlow S, Orsted H, Sibbald RG. Best practices for the prevention, diagnosis, and treatment of diabetic foot ulcers. .Ostomy Wound Manage 2000. ;46::55.–68; quiz 70–1.

    • PubMed
    • Search Google Scholar
    • Export Citation

Diagnosis and Treatment of Diabetic Foot Infections

Benjamin A. Lipsky Medical Service, Veterans Affairs Puget Sound Health Care System, and Division of General Internal Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington.

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Anthony R. Berendt Bone Infection Unit, Nuffield Orthopaedic Centre, Oxford, United Kingdom.

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H. Gunner Deery Northern Michigan Infectious Diseases, Petoskey, Michigan.

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John M. Embil Section of Infectious Diseases, Department of Medicine, University of Manitoba, Winnipeg, Manitoba.

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Warren S. Joseph Section of Podiatry, Department of Primary Care, Veterans Affairs Medical Center, Coatesville, Pennsylvania.

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Adolf W. Karchmer Division of Infectious Diseases, Department of Medicine, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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Jack L. LeFrock Dimensional Dosing Systems, Sarasota, Florida.

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Daniel P. Lew Department of Medicine, Service of Infectious Diseases, University of Geneva Hospitals, Geneva, Switzerland.

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Jon T. Mader Department of Internal Medicine, The Marine Biomedical Institute, and Department of Orthopaedics and Rehabilitation, University of Texas Medical Branch, Galveston, Texas; now deceased.

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Carl Norden Department of Medicine, New Jersey School of Medicine and Dentistry, and Cooper Hospital, Camden, New Jersey.

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James S. Tan Department of Internal Medicine, Summa Health System, and Northeastern Ohio Universities College of Medicine, Akron, Ohio.

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Reprints or correspondence: Dr. Benjamin A. Lipsky, Veterans Affairs Puget Sound Health Care System, S-111-GIMC, 1660 S. Columbian Way, Seattle, WA 98108-9804 (Benjamin.Lipsky@med.va.gov).
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