Nizzi FA Jr, Kaplan HS: Protein C and S deficiency. .Semin Thromb Hemost 25::265. ,1999. .
Sadiq A, Ahmed S, Karim A, et al: Acute myocardial infarction: a rare complication of protein C deficiency. .Am J Med 110::414. ,2001. .
Warkentin TE, Sikov WM, Lillicrap DP: Multicentric warfarin-induced skin necrosis complicating heparin-induced thrombocytopenia. .Am J Hematol 62::44. ,1999. .
Huseyin B, Dogan T, Anil A, et al: Progressive gangrene of the hand following extravasation of antibiotics associated with hereditary resistance to activated protein C. .Ann Plast Surg 41::194. ,1998. .
Onwuanyi A, Sachdeva R, Hamirani K, et al: Multiple aortic thrombi associated with protein C and S deficiency. .Mayo Clin Proc 76::319. ,2001. .
Cho YP, Lee DH, Jang HJ, et al: Peripheral arterial insufficiency associated with protein C deficiency. .Br J Radiol 75::843. ,2002. .
Adler SN, Adler-Klein D, Gasbarra DB: “Hematologic System,” in Pocket Manual of Differential Diagnosis, 4th Ed, p 223, Lippincott Williams & Wilkins, Philadelphia. ,1999. .
We describe the management of a patient who presented to a family-practice clinic with gangrenous digits. After a thorough evaluation, she was found to have protein C deficiency, which produced a hypercoagulable state. Differential diagnosis in the evaluation of the coagulopathic patient with appropriate hematologic tests is briefly discussed. (J Am Podiatr Med Assoc 95(5): 491–493, 2005)