Dyson M: “The Effect of Ultrasound on the Rate of Wound Healing and the Quality of Scar Tissue,” in Proceedings of the International Symposium on Therapeutic Ultrasound, Canadian Physiotherapy Association, Winnipeg, Manitoba. ,1981. .
Jackson BA, Schwane JA, Starcher BC: Effect of ultrasound therapy on the repair of Achilles tendon injury in rats. .Med Sci Sports Exerc23::171. ,1991. .
Ito M, Azuma Y, Ohta T, et al: Effects of ultrasound and 1,25 dihydroxyvitamin D3 on growth factor secretion in co-cultures of osteoblasts and endothelial cells. .Ultrasound Med Biol26::161. ,2000. .10687804)| false
Doan N, Reber P, Meghji S, et al: In vitro effects of therapeutic ultrasound on cell proliferation, protein synthesis, and cytokine production by human fibroblasts, osteoblasts, and monocytes. .J Oral Maxillofac Surg57::409. ,1999. .
Doan N, Reber P, Meghji S, et al: In vitro effects of therapeutic ultrasound on cell proliferation, protein synthesis, and cytokine production by human fibroblasts, osteoblasts, and monocytes. .J Oral Maxillofac Surg57::409. ,1999. .10199493)| false
Bacharach JM, Rooke TW, Osmundson PJ, et al: Predictive value of transcutaneous oxygen pressure and amputation success by use of supine and elevated measurements. .J Vasc Surg15::558. ,1992. .1538514)| false
Montori VM, Kavros SJ, Walsh EE, et al: Intermittent compression pump for nonhealing wounds in patients with limb ischemia, the Mayo Clinic experience (1998–2000). .Int Angiol21::360. ,2002. .12518117)| false
Background: A feasibility study was conducted to characterize the effects of noncontact low-frequency ultrasound therapy for chronic, recalcitrant lower-leg and foot ulcerations.
Methods: The study was an open-label, nonrandomized, baseline-controlled clinical case series. Patients were initially treated with the Mayo Clinic standard of care before the addition of or the switch to noncontact low-frequency ultrasound therapy. We analyzed the medical records of 51 patients (median ± SD age, 72 ± 15 years) with one or more of the following conditions: diabetes mellitus, neuropathy, limb ischemia, chronic renal insufficiency, venous disease, and inflammatory connective tissue disease. All of the patients had lower-extremity ulcers, 20% had a history of amputation, and 65% had diabetes. Of all the wounds, 63% had a multifactorial etiology, and 65% had associated transcutaneous oximetry levels below 30 mm Hg.
Results: The mean ± SD treatment time of wounds during the baseline standard of care control period versus the noncontact low-frequency ultrasound therapy period was 9.8 ± 5.5 weeks versus 5.5 ± 2.8 weeks (P < .0001). Initial and end measurements were recorded, and percent volume reduction of the wound was calculated. The mean ± SD percent volume reduction in the baseline standard of care control period versus the noncontact low-frequency ultrasound therapy period was 37.3% ± 18.6% versus 94.9% ± 9.8% (P < .0001).
Conclusions: Using noncontact low-frequency ultrasound improved the rate of healing and closure in recalcitrant lower-extremity ulcerations. (J Am Podiatr Med Assoc 97(2): 95–101, 2007)
Corresponding author: Steven J. Kavros, DPM, Mayo Clinic, 200 First St SW, Rochester, MN 55905.