advertising
-
1
Stern JM, Simes RJ: Publication bias: evidence of delayed publication in a cohort study of clinical research projects. .BMJ 315::640. ,1997. .
-
2
Olson CM, Rennie D, Cook D, et al: Publication bias in editorial decision making. .JAMA 287::2825. ,2002. .
-
3
Dickersin K, Olson CM, Rennie D, et al: Association between time interval to publication and statistical significance. .JAMA 287::2829. ,2002. .
-
4
Krzyzanowska MK, Pintilie M, Tannock IF: Factors associated with failure to publish large randomized trials presented at an oncology meeting. .JAMA 290::495. ,2003. .
-
5
Ioannidis JP: Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. .JAMA 279::281. ,1998. .
-
6
Redmond A: Two feet or one person?. The Foot 14::1. ,2004. .
-
7
Menz HB: Two feet, or one person? Problems associated with statistical analysis of paired data in foot and ankle medicine. .The Foot 14::2. ,2004. .
-
8
Menz HB: Analysis of paired data in physical therapy research: time to stop double-dipping?. J Orthop Sports Phys Ther 35::477. ,2005. .
-
9
Altman DG, Bland JM: Statistics notes: units of analysis. .BMJ 314::1874. ,1997. .
-
10
Altman DG, Bland JM: Absence of evidence is not evidence of absence. .BMJ 311::485. ,1995. .
-
11
Marks HM: Rigorous uncertainty: why RA Fisher is important. .Int J Epidemiol 32::932. ,2003. .
-
12
Young KD, Lewis RJ: What is confidence? part 2. Detailed definition and determination of confidence intervals. .Ann Emerg Med 30::311. ,1997. .
-
13
Hopkins WG: A new view of statistics. Available at: http://www.sportsci.org/resource/stats/index.html. Accessed April 9. ,2005. .
-
14
Bland JM, Altman DG: Measuring agreement in method comparison studies. .Stat Methods Med Res 8::135. ,1999. .
-
15
Beaton DE, Boers M, Wells GA: Many faces of the minimal clinically important difference (MCID): a literature review and directions for future research. .Curr Opin Rheumatol 14::109. ,2002. .
-
16
Landorf KB, Keenan AM: An evaluation of two foot-specific, health-related quality-of-life measuring instruments. .Foot Ankle Int 23::538. ,2002. .
-
17
Wolfe F, Michaud K, Strand V: Expanding the definition of clinical differences: from minimally clinically important differences to really important differences: analyses in 8931 patients with rheumatoid arthritis. .J Rheumatol 32::583. ,2005. .
Statistical and Clinical Interpretation of Research Results
Search for other papers by Garry T. Allison in
Current site
Google Scholar
PubMed
There is a well-known phenomenon of publication bias toward manuscripts that report statistically significant differences. The clinical implications of these statistically significant differences are not always clear because the magnitude of the changes may be clinically meaningless. This article relates the critical P value threshold to the magnitude of the actual observed change and provides a rationale for reporting confidence intervals in clinical studies. Strategies for improving statistical power and reducing the magnitude of the confidence interval range for clinical trials are also described. (J Am Podiatr Med Assoc 97(2): 165–170, 2007)
advertising
