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-
1
Lear W, Kessler E, Solish N, et al: An epidemiological study of hyperhidrosis. .Dermatol Surg 33::S69. ,2007. .
-
2
Lowe NJ, Yamauchi PS, Lask GP, et al: Efficacy and safety of botulinum toxin type a in the treatment of palmar hyperhidrosis: a double blind, randomized, placebo-controlled study. .Dermatol Surg 28::822. ,2002. .
-
3
Vadoud-Seyedi, J: Treatment of plantar hyperhidrosis with botulinum toxin type A. .Int J Dermatol 43::969. ,2004. .
-
4
Lai YT, Yang LH, Chio CC, et al: Complications in patients with palmar hyperhidrosis with transthoracic endoscopic sympathectomy. .Neurosurgery 41::110. ,1997. .
-
5
Saadia D, Voustianiouk A, Wang AK, et al: Botulinum toxin type A in primary palmar hyperhidrosis. .Neurology 57::2095. ,2001. .
-
6
Sevim S, Dogu O, Kaleagasi H: Botulinum toxin-A therapy for palmar and plantar hyperhidrosis. .Acta Neurol Belg 102::167. ,2002. .
-
7
Perez-Bernal A, Avalos-Peralta P, Moreno-Ramirez D, et al: Treatment of palmar hyperhidrosis with botulinum toxin type A : 44 months of experience. .J Cosm Derm 4::163. ,2005. .
-
8
Naumann M, Lowe NJ: Botulinum toxin type A in treatment of bilateral primary axillary hyperhidrosis: randomised, parallel group, double blind, placebo controlled trial. .Br Med J 323::596. ,2001. .
-
9
Smith KC, Comite SL, and Storwick GL: Ice minimizes discomfort associated with injection of botulinum toxin type A for the treatment of palmar and plantar hyperhidrosis. .Dermatol Surg 33::S88. ,2007. .
Injectable Botulinum Toxin as a Treatment for Plantar Hyperhidrosis
A Case Study
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Hyperhidrosis is defined as excessive and uncontrollable sweating due to overactivity of the eccrine sweat glands. The first line of treatment for plantar hyperhidrosis consists of conservative therapies such as topical solutions (ie, antiperspirant applications and aluminum chloride preparations) and iontophoresis. When the patient has failed these standard treatments, the other available medical options are rather limited and not well tolerated. Botulinum toxin type A (Botox, Allergan Inc, Irvine, California) is a purified neurotoxin complex approved by the US Food and Drug Administration in 2004 for multiple medical conditions, including severe primary axillary hyperhidrosis that failed conservative topical therapies. Few recent clinical studies have suggested that botulinum toxin is effective in the treatment of plantar hyperhidrosis. In this case study, two patients received intradermal injections of botulinum toxin type A into the plantar aspect of both feet. A 3-month follow-up evaluated the efficacy of botulinum toxin type A by subjectively assessing the amount of residual sweating. In these two patients, botulinum toxin type A was an effective and safe treatment for plantar hyperhidrosis. (J Am Podiatr Med Assoc 98(2): 156–159, 2008)
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