Holick M: Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. .Am J Clin Nutr 79::362. ,2004. .
Morgan S: Calcium and vitamin D in osteoporosis. .Rheum Dis Clin North Am 27::101. ,2001. .
Guyton AC, Hall JE: Textbook of Medical Physiology, 10th Ed, WB Saunders, Philadelphia. ,2000. .
Lyman D: Undiagnosed vitamin D deficiency in the hospitalized patient. .Am Fam Physician 71::299. ,2005. .
Utiger RD: The need for more vitamin D. .N Engl J Med 338::828. ,1998. .
Dawson-Hughes B, Harris SS, Krall EA, et al: Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. .N Engl J Med 337::670. ,1997. .
Thomas MK, Lloyd-Jones DM, Thadhani RI, et al: Hypovitaminosis D in medical inpatients. .N Engl J Med 338::777. ,1998. .
Chapuy MC, Arlot ME, Duboeuf F, et al: Vitamin D3 and calcium to prevent hip fractures in elderly women. .N Engl J Med 327::1637. ,1992. .
Genuth SM: “Endocrine regulation of the metabolism of calcium and related minerals,” in Principles of Physiology, 2nd Ed, ed by RM Berne, MN Levy, p 625, Mosby-Year Inc, St. Louis. ,1996. .
Vieth R, Ladak Y, Walfish PG: Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. .J Clin Endocrinol Metab 88::185. ,2003. .
Sanders LJ, Frykberg RG: “The Charcot Foot,” in The High Risk Foot in Diabetes Mellitus, ed by RG Frykberg, p 325, Churchill Livingstone, New York. ,1991. .
Kroop SF, Simon LS: “Joint and bone manifestations of diabetes mellitus” in Joslin’s Diabetes, 13th Ed, ed by CR Kahn, GC Weir, p 912, Lea & Febiger, Philadelphia. ,1994. .
Brower A, Allman R: Pathogenesis of the neurotrophic joint: neurotraumatic vs. .neurovascular. Diagn Radiol 139::349. ,1981. .
Llach F, Bover J: “Renal Osteodystropies,” in Brenner and Rector’s The Kidney, 6th Ed, ed by BB Brenner, p 2103, WB Saunders, Philadelphia. ,2000. .
Sanders LJ, Frykberg RG: “Charcot neuroarthropathy of the foot” in Levin and O’Neals’s The Diabetic Foot, 6th Ed, ed by JH Bowker, MA Pfeifer, St. Louis. ,2001. .
Eichenholtz, SN: Charcot Joints, ed by DD Thomas, Charles C Thomas, Springfield, IL. ,1966. .
Steingrimsdottir L, Gunnarsson O, Indridason I, et al: Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. .JAMA 294::2336. ,2005. .
Sigurdsson G, Franzson L, Steingrimsdottir L, et al: The association between parathyroid hormone, vitamin D and bone mineral density in 70-year-old Icelandic women. .Osteoporos Int 11::1031. ,2000. .
Malabanan A, Veronkis IE, Holick MF: Redefining vitamin D insufficiency. .Lancet 351::805. ,1998. .
McNair P, Madsbad S: Bone mineral loss in insulin-treated diabetes mellitus: studies on the pathogenesis. .Acta Endocrinol 90::463. ,1979. .
McNair P, Madsbad S, Christensen C: Bone loss in diabetics: effect of metabolic state. .Diabetologia 17::283. ,1979. .
Hui SL, Epstein S, Johnston CC: A prospective study of bone mass in patients with type I diabetes. .J Clin Endrocrinol Metab 60::74. ,1985. .
Suzuki A, Kotake M, Ono Y, et al: Hypovitaminosis D in type 2 diabetes mellitus: association with microvascular complications and type of treatment. .Endocr J 53::503. ,2006. .
Forsen L, Meyer HE, Midthjell K, et al: Diabetes mellitus and the incidence of hip fracture: results from Nord Trondelag Health Survey. .Diabetologia 42::920. ,1999. .
Ivers RQ, Cumming RG, Mitchell P, et al: Diabetes and risk of fracture: the Blue Mountains eye study. .Diabetes Care 24::1198. ,2001. .
Ledig-Bruckner G, Ziegler R: Diabetes mellitus a risk for osteoporosis? Exp Clin Endocrinol Diabetes 109: S493. ,2001. .
Trivedi DP, Doll R, Khaw KT: Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomized double blind controlled trial. .BMJ 326::1621. ,2003. .
Baynes JW: From life to death–the struggle between chemistry and biology during aging: the Maillard reaction as an amplifier of genomic damage. .Biogerontology 1::235. ,2000. .
Monnier VM: Toward a Malliard reaction theory of aging. .Prog Clin Biol Res 304::1. ,1989. .
Vlassara H, Bucala R, Striker L: Pathogenic effects of advanced glycosylation: biochemical, biological, and clinical implications for diabetes and aging. .Lab Invest 70::138. ,1994. .
Valcourt U, Merle B, Gineyts E, et al: Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation. .J Biol Chem 282::5691. ,2007. .
Katayama Y, Celic S, Nagata N, et al: Nonenzymatic glycation of type I collagen modifies interaction with UMR 201-10B preosteoblastic cells. .Bone 21::327. ,1997. .
McCarthy AD, Etcheverry SB, Cortizo AM: Advanced glycation end product specific receptors in rate and mouse osteoblastic-like cells: regulation with stages of differentiation. .Acta Diabetol 36::45. ,1999. .
McCarthy AD, Etcheverry SB, Bruzzone L, et al: Nonenzymatic glycosylation of a type I collagen matrix: effects on osteoblastic development and oxidative stress. .BMC Cell Biol 2::16. ,2001. .
Kume S, Kato S, Yamagishi S, et al: Advanced glycation end-products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. .J Bone Miner Res 20::1647. ,2005. .
McCarthy AD, Uemura T, Etcheverry SB, et al: Advanced glycation endproducts interfere with integrin-mediated osteoblastic attachment to a type-I collagen matrix. .Int J Biochem Cell Biol 36::840. ,2004. .
Heaney RP: Bone health. .Am J Clin Nutr 85::300S. ,2007. .
Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al: Higher 25-hydroxyvitamin D concentrations are associated with better lower extremity function in both active and inactive persons aged ≥ 60y. .Am J Clin Nutr 80::752. ,2004. .
Wicherts IS, Van Schoor NM, Boeke AJP, et al: Vitamin D deficiency and neuromuscular performance in the Longitudinal Aging Study Amsterdam (LASA). .J Bone Miner Res 20::S35. ,2005. .
Grant WP, Foreman EJ, Wilson AS, et al: Evaluation of Young’s modulus in Achilles tendons with diabetic neuroarthropathy. .JAPMA 95::242. ,2005. .
Background: This study was designed to compare the vitamin D levels in a cohort of nondiabetic patients to populations of diabetic patients with and without Charcot neuroarthropathy.
Methods: A total of 41 participants (22 male, 19 female) with a mean ± SD age of 59 ± 9.43 years had serum 25-hydroxyvitamin D levels tested. Fifteen participants composed the nondiabetic group; 13, the group with diabetes but without Charcot neuroarthropathy; and 13, the group with both diabetes and Charcot neuroarthropathy.
Results: The results of the study showed that the vitamin D levels in both diabetic populations were significantly lower (P < .05) than the nondiabetic population. There was no statistical difference between the group with diabetes but without Charcot foot disease and the group with both diabetes and Charcot neuroarthropathy.
Conclusions: Based on the results of this study, given the importance of vitamin D in bone metabolism and the osseous consequences associated with diabetes, as well as other systems affected by low levels of vitamin D in the diabetic patient, it appears that vitamin D levels should be monitored in diabetic patients. (J Am Podiatr Med Assoc 99(1): 35–41, 2009)