Dewdney JM: Effects of beta-lactam antibiotics on eukaryotic cells. .Cell Biol Toxicol 4::509. ,1986. .
Hancock RE: Mechanisms of action of newer antibiotics for gram-positive pathogens. .Lancet Infect Dis 5::209. ,2005. .
Hope WW, Billaud EM, Lestner J, et al: Therapeutic drug monitoring for triazoles. .Curr Opin Infect Dis 6::580. ,2008. .
Pasqualotto AC, Denning DW: New and emerging treatments for fungal infections. .J Antimicrob Chemother 61: (Suppl 1):i19. ,2008. .
Verkruysse W, Wangcun J, Walfre F, et al: Infrared measurement of human skin temperature to predict the individual maximum safe radiant exposure (IMSRE). .Lasers Surg Med 39::757. ,2007. .
Dawson E, Willey A, Lee K: Adverse events associated with nonablative cutaneous laser, radiofrequency, and light-based devices. .Semin Cutan Med Surg 26::15. ,2007. .
Crissey JT: Common dermatophyte infections: a simple diagnostic test and current management. .Postgrad Med 103::191. ,1998. .
Elewski BE: Onychomycosis: pathogenesis, diagnosis, and management. .Clin Microbiol Rev 11::415. ,1998. .
Bornstein ES, Robbins AH, Michelon M: Photo-inactivation of fungal pathogens that cause onychomycosis in vitro and in vivo with the Noveon dual wavelength laser system. Abstract presented at: New Cardiovascular Horizons, September 10–13. ,2008. , New Orleans, LA.
Bornstein ES, Krespi YP, Robbins AH, et al: Antimicrobial resistance reversal at physiologic temperatures in mrsa in the nares with an 870 nm and 930 nm dual wavelength Noveon laser. Abstract presented at: Tissue Engineering and Regenerative Medicine International Society, December 7–10. ,2008. , San Diego, CA.
Bornstein E, inventor: Near-infrared electromagnetic modification of cellular steady-state membrane potentials. US patent application 20080139992. June 12. ,2008. .
Harris DM, Yessik M: Therapeutic ratio quantifies laser antisepsis: Ablation of Porphyromonas gingivalis with dental lasers. .Lasers Surg Med 35::206. ,2004. .
Harris DM: “Laser antisepsis of Porphyromonas gingivalis in vitro with dental lasers” in Proceedings from the Society of Photo-Optical Instrumentation Engineers; January 25. ,2004. ; San Jose, CA.
Harris DM, Jacques SE: Computer simulation of depth of kill of P gingivalis in dentin by laser based on experimental damage threshold. .Lasers Surg Med 36: (suppl):17. ,2005. .
Marjaron B, Plestenjak P, Luka CM: Thermo-mechanical laser ablation of soft biological tissue: modeling the micro-explosions. .Applied Physics B 69::71. ,1999. .
Dai T, Tegos GP, Rolz-Cruz G, et al: Ultraviolet C inactivation of dermatophytes: implications for treatment of onychomycosis. .Br J Dermatol 158::1239. ,2008. .
Cumbie B, Juanarena D, inventors; Method and device to inactivate and kill cells and organisms that are undesirable, Section 4.7 Enhanced Penetration of Germicidal Radiation through Tissues by Use of Pulsed Polychromatic Light. World Intellectual Property Organization WO/2007/ 123859..
Boker A, Cumbie B, Kimball A: A single-center, prospective, open-label, pilot study of the safety, local tolerability, and efficacy of ultraviolet-C (UVC) phototherapy for the treatment of great toenail onychomycosis. Poster presented at: 66th Annual Meeting of the American Academy of Dermatology, February 1–5, 2008, San Antonio, TX..
Boker A, Cumbie B, Kimball A: A single-center, prospective, open-label, pilot study of the safety, local tolerability, and efficacy of ultraviolet-C (UVC) phototherapy for the treatment of great toenail onychomycosis. Poster presented at: the 21st World Congress of Dermatology, September 30–October 5. ,2007. , Buenos Aires, Argentina.
Cumbie B, Juanarena D, inventors: Phototherapy treatment and device to improve the appearance of nails and skin. US patent application 20080208295. August 28. ,2008. .
Neuman KC, Chadd EH, Liou GF, et al: Characterization of photodamage to Escherichia coli in optical traps. .Biophys J 77::2856. ,1999. .
Bornstein ES, Michelon M: Examining the antibacterial action spectrum in vitro of the Noveon dual wavelength laser system through photo-inactivation of E. coli at physiologic temperatures. Abstract presented at: American Society for Laser Medicine and Surgery Laser Conference; April 3. ,2009. ; Oxon Hill, MD.
Dewhirst MW, Viglianti BL, Lora-Michiels M, et al: Principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia. .Int J Hyperthermia 19::267. ,2003. .
Bornstein ES: Treatment of Onychomycosis Using the Noveon Dual-Wavelength Laser. FDA Pivotal Study data presented at: Council for Nail Disorders 13th Annual Meeting, March 5. ,2009. , San Francisco, CA.
Schroeder P, Haendeler J, Krutmann J, et al: The role of near infrared radiation in photoaging of the skin. .Exp Gerontol 43::629. ,2008. .
Schieke SM, Schroeder P, Krutmann J, et al: Cutaneous effects of infrared radiation: from clinical observations to molecular response mechanisms. .Photodermatol Photoimmunol Photomed 19::228. ,2003. .
Kim MS, Kim YK, Cho KH, et al: Regulation of type I procollagen and MMP-1 expression after single or repeated exposure to infrared radiation in human skin. .Mech Ageing Dev 127::875. ,2006. .
Schroeder P, Lademann J, Darvin ME, et al: Infrared radiation-induced matrix metalloproteinase in human skin: implications for protection. .J Invest Derm 128::2491. ,2008. .
Schieke SM, Stege H, Kurten V, et al: Infrared-A radiation-induced matrix metalloproteinase 1 expression is mediated through extracellular signal-regulated kinase 1/2 activation in human dermal fibroblasts. .J Investig Derm 119::1323. ,2002. .
Geusic JE, Marcos HM, Van Uitert LG: Laser oscillations in Nd-doped yttrium aluminum, yttrium gallium and gadolinium garnets. .Appl Phys Lett 4::182. ,1964. .
Solomon H, Goldman L, Henderson B, et al: Histopathology of the laser treatment of port-wine lesions. Biopsy studies of treated areas observed up to three years after laser impacts. .J Invest Derm 50::141. ,1968. .
Venugopalan V, Nishioka NS, Mikic BB: The thermodynamic response of soft biological tissues to pulsed infrared-laser irradiation. .Biophys J 70::2981. ,1996. .
Harris D, Gregg RH, McCarthy DK, et al: Laser-assisted new attachment procedure in private practice. .General Dentistry 52::396. ,2004. .
Gupta AK, Ahmad I, Borst I, et al: Detection of xanthomegnin in epidermal materials infected with Trichophyton rubrum.. J Invest Dermatol 115::901. ,2000. .
Vural E, Winfield HL, Shingleton AW, et al: The effects of laser irradiation on Trichophyton rubrum growth. .Lasers Med Sci 23::349. ,2008. .
Demetriou C, Hsia J, inventors: Treating a diseased nail. World Intellectual Property Organization WO/2006/076506..
Demetriou C, Hsia J, inventors: Method and apparatus for treating a diseased nail. US patent application 20060212098. September 21, 2006..
Vandiver JK, Kennedy P: Harold Eugene Edgerton 1903–1990, A Biographical Memoir, The National Academies Press, Washington, DC, 2005. Available at: http://books.nap.edu/html/biomems/hedgerton.pdf. Accessed June 11. ,2009. .
Edgerton H, Cathou P: Xenon flash tube of small size. .Rev Sci Instr 27::821. ,1956. .
Kubey W, Holmes CJ: In vitro studies on the microbicidal effectiveness of a xenon-based ultraviolet light device for continuous ambulatory peritoneal dialysis connections. .Blood Purif 9::102. ,1991. .
Thai TP, Keast DH, Campbell KE, et al: Effect of ultraviolet light C on bacterial colonization in chronic wounds. .Ostomy Wound Manage 51::32. ,2005. .
Thai TP, Houghton PE, Keast DH, et al: Ultraviolet light C in the treatment of chronic wounds. .Ostomy Wound Manage 48::52. ,2002. .
Chadwick CA, Potten CS, Nikaido O, et al: The detection of cyclobutane thymine dimers, (6-4) photolesions and the Dewar photoisomers in sections of UV-irradiated human skin using specific antibodies, and the demonstration of depth penetration effects. .J Photochem Photobiol B 28::163. ,1995. .
US Department of Health and Human Services. Ultraviolet radiation related exposures-report on carcinogens, 11th Ed. Available at: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s183uvrr.pdf. Accessed June 11. ,2009. .
Matsumu Y, Ananthaswamy HN: Toxic effects of ultraviolet radiation on the skin. .Toxicol Appl Pharmacol 195::298. ,2004. .
Recently, there has been a resurgence of interest in potential phototherapy technologies for the local treatment of bacterial and fungal infection. Currently, onychomycosis is the principle disease that is the target of these phototherapies in podiatric medicine. Some of these technologies are currently undergoing in vitro and in vivo trials approved by institutional review boards. The three light-based technologies are ultraviolet light therapy, near infrared photo-inactivation therapy, and photothermal ablative antisepsis. Each of these technologies have markedly dissimilar mechanisms of action. In this review, each technology will be discussed from the perspectives of history, photobiology, individual mechanism of action, safety, and potential clinical efficacy, with data presented from published material. This review is intended to give podiatric physicians detailed information on state-of-the-art infectious disease phototherapy. (J Am Podiatr Med Assoc 99(4): 348–352, 2009)