• 1

    Gulcan E, Gulcan A, Erbilen E, et al: Statins may be useful in diabetic foot ulceration treatment and prevention. .Med Hypotheses 6::1313. ,2007. .

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  • 2

    Chow I, Lemos EV, Einarson TR: Management and prevention of diabetic foot ulcers and infections: a health economic review. .Pharmacoeconomics 12::1019. ,2008. .

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  • 3

    Kalinowski L, Dobrucki LW, Szczepanska-Konkel M, et al: Third-generation beta blockers stimulate nitric oxide release from endothelial cells through ATP efflux: a novel mechanism for antihypertensive action. .Circulation 107::2747. ,2003. .

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  • 4

    Mason RP, Kubant R, Jacob RF, et al: Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: role of antioxidant activity. .J Cardiovasc Pharmacol 48::862. ,2006. .

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  • 5

    Maffei A, Vecchione C, Aretini A, et al: Characterization of nitric oxide release by nebivolol and its metabolites. .Am J Hypertens 19::579. ,2006. .

  • 6

    Broeders MA, Doevendans PA, Bekkers BC, et al: Nebivolol: a third-generation beta-blocker that augments vascular nitric oxide release: endothelial beta(2)-adrenergic receptor-mediated nitric oxide production. .Circulation 102::677. ,2000. .

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  • 7

    Gulcan E, Ilhan D, Toker S: Nebivolol might be beneficial in the prevention and treatment of diabetic neuropathy. .Am J Ther. [Published online ahead of print December 23, 2008].

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  • 8

    Taddei S, Virdis A, Ghiadoni L, et al: Effects of antihypertensive drugs on endothelial dysfunction: clinical implications. .Drugs 62::265. ,2002. .

Could Nebivolol be an Alternative Drug for the Treatment of Diabetic Foot Ulcers?

Erim GulcanDumlupinar University School of Medicine, Department of Internal Medicine, Merkez Kampus, Kutahya, 43100 Turkey

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