Verrucae are small, benign, highly vascular epithelial neoplasms that occur singly or in a multiple presentation. Plantar verrucae are usually caused by infection with human papillomavirus types 1, 2, and 4. A clinical trial was conducted to assess the safety and efficacy of monochloroacetic acid and 10% formaldehyde versus 10% formaldehyde alone in the treatment of simple plantar verrucae. Of 57 patients enrolled in the study, 26 were in the monochloroacetic acid and 10% formaldehyde group and 31 were in the 10% formaldehyde alone group. The overall cure rate for this population was 61.4%. There was no statistically significant difference in the cure rate between treatment groups. (J Am Podiatr Med Assoc 96(1): 53–58, 2006)
Background: Heel pain, bunion pain, and other forms of foot pain syndromes are one of the more common reasons a patient visits a podiatrist. Numerous methods are currently available to attempt to achieve pain relief, including pharmaceuticals, magnets, heat, and electrical stimulation. A textile company developed Pain Checker socks (Pain Checker Health Wear, Cresskill, New Jersey), which contains a material that may counter the circuit of pain and oppose the effect, thereby stopping the conduction of pain.
Methods: The purpose of this placebo-controlled, double-blind clinical trial was to evaluate the safety and efficacy of Pain Checker socks in the treatment of mild-to-moderate foot pain. Fifty patients were enrolled, half on active and half on placebo socks. The subjects were evaluated at baseline, 2, 4, and 6 weeks of treatment.
Results: There was no statistically significant difference in disability, pain, or activity scales between treatment groups, although only 5% of the treatment group received no pain relief on visual analog scale during the trial, while 38% of the placebo group received no pain relief.
Conclusion: Although there was no difference in pain relief, the Pain Checker socks were found to be safe and scored high in patient satisfaction. The unique fiber content and construction of the socks may have contributed to the placebo analgesia. (J Am Podiatr Med Assoc 98(4): 278–282, 2008)
Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common. This double-blind, randomized clinical trial investigated the effect of Lactinol (Pedinol Pharmaceuticals, Farmingdale, New York) versus Lac-Hydrin 12% (Bristol-Myers Squibb, Princeton, New Jersey) lotion in mild to moderate foot xerosis. Clinical assessment of xerosis was performed at baseline visit, and the designated sites were evaluated at 2 and 4 weeks after treatment began. Of the 53 patients enrolled, 18 were excluded from analysis. Although both treatment groups had significantly improved xerosis scores after 2 and 4 weeks of treatment, no statistically significant difference was observed. Of the 44% of patients who did express a preference, 72% preferred Lactinol, which may account for the 20% increase in its overall use in the study. (J Am Podiatr Med Assoc 92(3): 143-148, 2002)